Auditory nerve brain-stem (ABR) and somatosensory evoked responses (SER) were recorded in cats as body temperature was uniformly lowered from 37 to 27 degrees C. Analysis of the results showed that the alterations in the evoked responses were due to disturbances induced both in axonal propagation and synaptic transmission by the hypothermia. By studying the first wave of the SER, which is solely an axonal event, and by assuming reasonable values for the total synaptic delay and axonal propagation times along the ABR pathway, it was concluded that this lesion model induced an effect on synaptic transmission 1.3-1.7 times greater than that on axonal propagation. There was a strong inverse correlation between wave latency and body temperature, with slightly steeper slopes for the longer latency waves. Wave amplitudes were not correlated with temperature. Furthermore, the wave latencies and amplitudes were generally not dependent on stimulus rate.

Animals↗

PubMedDate not supplied

Hypercoagulability in otologic patients.

INTRODUCTION: Three patients with otologic disorders developed complications related to hypercoagulability. This report was prepared to increase the awareness among otolaryngologists of the diagnosis and management of hypercoagulable states, and to encourage expert consultation when indicated. MATERIALS AND METHODS: One patient with dural venous sinus thrombosis complicating an otitis media, one patient with a large glomus jugulare tumor, and one patient with a sudden sensorineural hearing loss were treated by the otolaryngology service. Suspicious thromboembolic events were evaluated by the hematology service, and appropriate anticoagulative therapy was recommended. RESULTS: One patient with an inherited hypercoagulopathy and two patients with acquired hypercoagulopathies were treated for otologic problems. Two of the patients were stabilized and discharged on life-long anticoagulation therapy. The third patient, in spite of intensive medical and surgical support, eventually succumbed to complications to which an acquired hypercoagulable state made a significant contribution. Expert consultants made the hematologic diagnoses and treatment recommendations. CONCLUSION: Otolaryngologists should be aware that hypercoagulable states may now be more accurately diagnosed and characterized, and that thorough investigation of thromboembolic events may affect treatment decisions.

Adult↗

PubMedDate not supplied

Methylation of deoxyribonucleic acid in the rat by the mushroom poison gyromitrin.

Explore the source record for details and available documents.

Acetaldehyde↗

PubMedDate not supplied

A gene from Pseudomonas syringae pv. glycinea with homology to avirulence gene D from P. s. pv. tomato but devoid of the avirulence phenotype.

A gene was cloned from Pseudomonas syringae pv. glycinea that hybridized to avirulence gene D (avrD), previously cloned from P. s. pv. tomato. Unlike avrD, the hypersensitive response (HR) was not elicited when the P. s. pv. glycinea gene was reintroduced into P. s. pv. glycinea race 4 on a broad host range plasmid and the bacteria were inoculated into soybean leaves. DNA sequence data disclosed that the P. s. pv. glycinea homologue of avrD encoded a protein containing 86% identical amino acids to avrD, with substitutions distributed throughout the protein. Two ORFs immediately downstream from the avrD homologue were more similar in P. s. pv. tomato and P. s. pv. glycinea, with 98 and 99% identical amino acids. Expression of the wildtype P. s. pv. glycinea gene and recombinant genes constructed between the P. s. pv. tomato avrD gene and its P. s. pv. glycinea homologue in both Escherichia coli and P. s. pv. glycinea indicated that the P. s. pv. glycinea gene product was formed less efficiently or was less stable than was the P. s. pv. tomato protein encoded by avrD. The data indicated that the P. s. pv. glycinea homologue represents a recessive allele of the P. s. pv. tomato avrD gene which has been modified by mutation such that it does not lead to an avirulence phenotype on the normal host plant, soybean.

Amino Acid Sequence↗

PubMedDate not supplied

Comparison between self-hypnosis, masking and attentiveness for alleviation of chronic tinnitus.

The efficacy of self-hypnosis (SH), masking (MA) and attentiveness to the patient's complaints (AT) in the alleviation of tinnitus was evaluated. Forty-five male patients close in age with chronic tinnitus related to acoustic trauma were assigned to three matched subgroups: SH, AT or MA. The therapeutic stimuli in the SH and MA sessions, recorded on audio cassettes, were given to the patients for use when needed. SH significantly reduced the tinnitus severity; AT partially relieved the tinnitus; MA did not have any significant effect.

Adult↗

PubMedDate not supplied

Community-based educational programs for cancer nursing.

A United Way grant allowed the Department of Nursing Research and Education to make available its expertise in cancer nursing and establish itself as a resource for oncology. Community educational needs were assessed by a questionnaire sent to outside agencies prior to designing an oncology educational program. In a 9-month period, 57 classes at 21 different facilities representing 417 hours of instruction were provided. Nurses attending the classes totaled 1,175. Results showed an increase in scores from pre-test to post-test, indicating that participants demonstrated increased knowledge as a result of class participation. This funding provided the catalyst to prepare a large number of community hospital nurses in the complex care of oncology patients.

Adult↗