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Biomedical subjects

S Ghosh

Publications and source records attributed to S Ghosh.

At least 1,009 records · Page 56Linked to original sources
PubMed1979

Site of action of RNase I on the 50 S ribosome of Escherichia coli and the association of the enzyme with the partially degraded subunit.

The 50 S ribosome of Escherichia coli is partially degraded by RNase I in presence of a high concentration of Mg2+ (10 to 20 mM); the partially degraded subunit becomes resistant to the further action of RNase I. The latter remains latent in association with the subparticle as in case of 30 S ribosome (Neu, H.C., and Heppel, L.A. (1954) Proc. Natl. Acad. Sci. U.S.A. 51, 1267-1274). As a result of nucleolytic action, 23 S RNA is degraded to a smaller size and four proteins (L4, L10, L7/L12) are released from the subunit. From the location of these proteins, it appears that the primary site of action of RNase I is the central protuberance of the armchair model proposed for the subunit (Stoffler, G., and Whitman, H.G. (1977) in Molecular Mechanisms of Protein Biosynthesis (Weissbach, H., and Pestka, S., eds) pp. 117-144, Academic Press, New York).

Escherichia coli↗
PubMed1979

Biochemical mechanism of nitrofurantoin resistance in Vibrio el tor.

Vibrio el tor cells contain a constitutive reductase enzyme which converts nitrofurantoin to an active principle that is responsible for the observed antibacterial activity of the drug. Acquisition of resistance of this strain towards nitrofurantoin is associated with the loss of this reductase. This enzyme is located in the periplasmic region of the nitrofurantoin-sensitive cells, and seems to play an important role in transporting the drug into the cells.

Drug Resistance, Microbial↗
PubMed1979

Hepatic dysfunction in childhood malaria.

Hepatic function of 80 children aged under 3 years with Plasmodium vivax malaria were studied during the acute attack and 6 weeks after antimalarial treatment. Raised levels of serum aspartate transaminase (serum AST; SGOT), serum alanine transaminase (serum ALT; SGPT), and alkaline phosphatase were observed in 68%, 39% and 46% of cases respectively. AST levels were higher than ALT ones and the mean level of both enzymes was much higher in patients with hepatomegaly. The hepatic dysfunction which these observations reflect is transient, as these enzymes were found to be at their normal levels 6 weeks after treatment. A transient derangement of liver function is thus a common feature of childhood malaria, and hepatic dysfunction takes place to a significant degree even in P. vivax malaria.

Acute Disease↗
PubMed1979

Hepatitis B surface antigen (HBsAg) in leprosy patients of Calcutta: its prevalence and subtypes.

Hight incidence of hepatitis B surface antigen (HBsAg) in lepromatous leprosy patients have been reported by many workers. This paper reports on a study undertaken over a period of more than two years to determine the prevalence of HBsAg and its major antigenic subtypes amongst the various clinical types of leprosy and apparently healthy individuals of Calcutta population. The overall incidence of HBsAg in lepromatous leprosy is found to be 3.8% (9 out of 234) in our study. The incidence of HBsAg in tuberculoid leprosy and non leprosy control cases were almost identical, 2.5% (11 out of 431) and 2.7% (14 out of 519) respectively. The incidence of HBsAg in lepromatous leprosy in the present study was apparently higher than tuberculoid or non leprosy cases, although statistically not significant. Hence the association between HBsAg and lepromatous leprosy could not be established in our study. None of the major antigenic subtypes of HBsAg could be related to any particular type of leprosy. The subtypes 'ad', 'ay' and 'ar' were present at varying proportions in all the groups tested. The antigenic subtype 'ay' was found to be prevalent in Calcutta population in higher proportions.

Adolescent↗
PubMed1979

Nature and familial character of lepromin sensitivity in 27 families and their siblings.

A group of 27 families consisting of 176 individuals had been investigated for the lepromin sensitivity (with Dharmendra antigen). The families were arranged under group A (9 families) in whom either of the parents or both were suffering from Lepromatous type of leprosy, group B numbering 4 families, of whom either of the parents or both were suffering from non-lepromatous type of leprosy and group C comprising 14 families where none of the parents was suffering from leprosy but some of the each family had the disease in their siblings. The present study points towards the possible genetic influence on lepromin sensitivity but at times may be influenced by the environmental factors. However the study does not permit to reach any valid conclusions; further elaborate investigations alone could prove the useful role of genetic influence in the propagation of lepromin sensitivity to the subsequent sibs.

Adolescent↗