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Biomedical subjects

S G Kushner

Publications and source records attributed to S G Kushner.

24 records · Page 2Linked to original sources
PubMed1977

[Results of a comparative study of anti-brain antibodies in the sera of healthy subjects and schizophrenic patients by the Coon's indirect immunofluorescent method].

With the aid of the Coombs indirect method the authors studied the blood sera of 79 patients with different forms of schizophrenia and 27 normal donors. It was demonstrate that the blood sera of schizophrenic patients and normals contain globulins capable of fixation on different components of a nervous cell. However, the character and intensity of fluorescence as well as the amount of fluorescent nerve cells in the field of vision distinguishes the examined patients from normal donors.

Autoantibodies↗
PubMed1976

Studies on human brain-thymus cross-reactive antigens.

Antigens shared by human brain and thymocytes and by human and mouse tissues were studied with rabbit anti-human thymocyte antiserum (RAHT). It was found that cytotoxicity of RAHT serum against mouse thymus cells was not absorbed by mouse liver or bone marrow cells. Human brain and thymus cells completely absorbed the anti-thymocyte activity from this antiserum. It was suggested that human brain had antigenic determinants identical or very similar to those found on human thymocytes. Activity of RAHT antiserum against mouse thymus cells was completely removed by an absorption of mouse brain and thymocytes. These results demonstrated that there were shared antigenic determinants between human and mouse tissues.

Adult↗
PubMed1975

[The neurotropic and autoimmune activity of the serum of patients with psychoses of old age and patients with schizophrenia].

In order to define the specificity of neurotropic and autoimmune activity in blood serum of schizophrenic patients the authors studied the existence of such biological signs in another group of patients with mental disorders of a nonschizophrenic etiology: Pick's and Alzheimer's disease. It was established that to neurotropic and autoimmune activity the blood serum of atrophic patients do not differ according to these signs from schizophrenic patients. At the same time it was established that in the nonschizophrenic group the neurotropic and autoimmune activity intercorrelated. A high neurotropic activity can be seen in those patients who display antibrain antibodies in the blood. In the group of schizophrenic patients such correlations were not demonstrated. It is assumed that the neurotropic and autoimmune processes in the organism of schizophrenic patients develop independently.

Adult↗