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Biomedical subjects

S G Anderson

Publications and source records attributed to S G Anderson.

At least 37 records · Page 2Linked to original sources
PubMed1980

Management of threatened abortion with real-time sonography.

Real-time sonography was used to evaluate 158 patients with threatened abortion. Fetal motion was first detected during the seventh gestational week and with increasing frequency thereafter in 73 patients with viable pregnancies continuing to term. Only 2 of 65 patients who aborted demonstrated fetal motion. The presence or absence of fetal motion was most reliable after 7 weeks' gestation for establishing a prognosis for a given pregnancy. Seventy-two of 74 pregnancies with fetal motion continued to term, whereas 63 of 64 pregnancies without fetal motion aborted. A method for using real-time sonography in the management of threatened abortion is presented.

Abortion, Threatened↗
PubMed1979

A case of automobile trauma during pregnancy.

Accidental injury is an important complication of pregnancy. In North Carolina the rate of maternal deaths secondary to accidents has remained constant since 1966; however, because of a reduction in other causes, the percentage of maternal deaths due to accidents has doubled (11.4%). As a result, it is appropriate to reassess the evaluation of injuries sustained in automobile accidents. A case of automobile trauma to a pregnant woman at term is presented, and a plan of management involving fetal monitoring is recommended.

Accidents, Traffic↗
PubMed1978

Real-time sonography in obstetrics.

Three hundred fifty real-time scans were performed on pregnant women for various indications. Placental localization was satisfactorily obtained in 173 of 174 studies. Estimates of fetal gestation from directly measured biparietal diameter were +/-2 weeks of actual gestation in 153 of 172 (88.9%) measurements. The presence or absence of fetal motion and cardiac activity established a diagnosis of fetal viability or fetal death in 32 patients after the first trimester. Accurate diagnosis was made in 52 of 57 patients with threatened abortions, and two of these errors occurred in scans performed before completion of the eighth postmenstrual week. Because of the ability to demonstrate fetal motion, real-time sonography should have many applications in obstetrics.

Abortion, Threatened↗
PubMed1977

Differential reactivity of the gravid uterine vasculatures: effects of norepinephrine.

Norepinephrine dose-conductance-response relationships were determined for the placental and nonplacental vasculatures of ewes between 95 and 130 days of gestation with the use of radioactive-labeled microspheres injected under flow meter guidance. The regression line for the placental circulation differed significantly from that for the nonplacental circulation (P less than 0.01). The decrease in nonplacental conductance was 30 to 45% of control greater than the decrease in placental conductance. These responses are consistent with the hypothesis that the site of placental vascular resistance is in vessels of larger caliber than those which are usually the primary site of resistance to blood flow.

Animals↗
PubMed1977

Uterine blood flow and its distribution after chronic estrogen and progesterone administration.

The rates and distributions of uterine blood flow (UBF) were measured in conscious castrated ewes during estradiol, progesterone, and combined-hormone regimens. Supplemental progesterone decreased the magnitude of UBF observed on estradiol alone. Progesterone favored distribution of UBF to the uterine caruncles and estradiol favored distribution to the myometrium and uterine cervix. Proportionate endometrial blood flows were similar on all hormone regimens. These observations suggest that estradiol secretion may not be responsible for the definitive increase in UBF observed during ovine pregnancy.

Animals↗
PubMed1977

A clinical evaluation of the "roll-over test" for pregnancy-induced hypertension.

A study of the capability of the roll-over test to predict pregnancy-induced hypertension was undertaken using our private patients. Sixty primigravid and 60 multigravid patients were studied between the twenty-eighth and thirty-second week of gestations. These patients were chosen at random by one of our two nurses who conducted all these studies. All results were recorded but were not available to the physicians. Eighteen months later, after all study patients had delivered, the hospital charts and the patients' office records were evaluated to determine if preganancy-induced hypertension had occurred. In primigravid patients a positive test accurately predicted the later development of pregnancy-induced hypertension only 50 per cent of the time while a negative test accurately predicted that it would not develop 93 per cent of the time. In multigravid patients, only 25 per cent of the patients who had positive tests later developed hypertension. The negative test in multigravid patients was accurate 94 per cent of the time.

Blood Pressure Determination↗
PubMed1976

Uterine pressure-flow relationships during early gestation.

Placental and myoendometrial pressure-flow relationships were determined in 17 gravid ewes between 29 and 110 gestational days with the use of radioactive-labeled microsphere injections under flow meter guidance. Myoendometrial relationships were consistently curvilinear with convexity toward the flow axis. From 29 to 40 days, caruncular-cotyledonary relationships were similar to myoendometrial ones. After 50 days, the relationship was slightly but significantly curvilinear with convexity toward the pressure axis. From 42 to 50 days, responses were intermediate. The changes in caruncle-cotyledon vascular reactivity correlated with the onset and maturation of interdigitation of fetal and maternal tissues during definitive placentation. A hypothesis for these changes in vascular reactivity is presented.

Animals↗
PubMed1976

Effects of local anesthetic agents on the uterine vasculatures and myometrium.

Intravascular procaine, lidocaine, mepivacaine, and bupivacaine decrease blood flow to the placental and nonplacental vascular beds of gravid ewes by stimulating vasoconstriction and myometrial contractility. These effects appear to be direct ones since they are not affected by alpha-adrenergic blockade. Dose-response curves determined in nonpregnant ewes indicate that significant decreases in blood flow may occur at arterial blood concentrations encountered clinically. It is proposed that reduced placental blood flow is the cause of fetal bradycardia following paracervical block anesthesia. The implications of these findings in obstetric anesthesia are discussed.

Anesthesia, Conduction↗
PubMed1975

First British standard for carcinoembryonic antigen (CEA).

In 1974, the National Institute for Biological Standards and Control (NIBSC) established the first British Standard for carcinoembryonic antigen (CEA) for use in comparative quantitative assays. The Standard, which was prepared for material processed by the Chester Beatty Research Institute, is in the form of a freeze-dried powder, sealed in all glass ampoules code labelled 73/601 and containing pure dry nitrogen. For practical purposes, each ampoule contains 100 units of CEA activity.

Amino Acids↗