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Biomedical subjects

S Fukuda

Publications and source records attributed to S Fukuda.

At least 757 records · Page 42Linked to original sources
PubMed1983

Hereditary multisystemic degeneration with unusual combination of cerebellipetal, dentato-rubral, and nigro-subthalamo-pallidal degenerations.

An autopsy case of a 51-year-old housewife with dominantly inherited ataxia is reported. Pathologic examination revealed an unusual combination of systemic degenerations: spinocerebellar tracts, pontine basis and middle cerebellar peduncles, dentato-rubral and nigro-subthalamo-pallidal systems, upper and lower motor neurons, ascending sensory system, and optic tracts. The inferior olive and cerebellar cortex showed only a slight change. The combination of the dentato-rubral with nigro-subthalamo-pallidal degenerations in a case with cerebellipetal systemic degeneration was particularly striking. Furthermore, combined degeneration of the ocular motor nuclei, vestibular nuclear group, perihypoglossal nuclei, fastigial nucleus, medial longitudinal fasciculus, and vestibulospinal tracts occurred. According to recent experimental results, these lesions were restricted precisely to the anatomophysiologically interrelated system for the control of eye movement. The present case is considered an example of systemic degeneration as a pathologic basis for ophthalmoplegia.

Brain Diseases↗
PubMed1983

Primary malignant melanoma of the vulva associated with pregnancy: clinical, light and electron microscopic observations.

A case of primary malignant melanoma of the vulva associated with pregnancy in a 31-year-old patient is reported. The primary tumor was first found at week 14 of pregnancy and biopsied on delivery at week 41 of pregnancy. Microscopically, the depth of invasion was Level V. Radical vulvectomy and bilateral inguino-femoral lymphadenectomy were performed and the right inguinal lymph node was positive for metastatic tumor. Chemoimmunotherapy with DTIC, ACNU, VCR and OK432 was undertaken as treatment for this malignant melanoma. Moreover, a comparison of scanning and transmission electron microscopic studies of the original tumor was carried out. This patient is now living 23 months after diagnosis without clinical evidence of recurrence.

Adult↗
PubMed1983

Direct effects of ketamine on isolated canine cerebral and mesenteric arteries.

The effects of ketamine on isolated canine cerebral (middle cerebral and basilar) and mesenteric arteries were studied. In arteries contracted with KCl, ketamine in concentrations above 5 X 10(-6)M (cerebral arteries) or 2 X 10(-5)M (mesenteric arteries) caused significant relaxation in a dose-dependent manner. The relaxation was not significantly influenced by aminophylline, aspirin, atropine, or propranolol. In concentrations above 5 X 10(-6)M ketamine attenuated the contractile response to high concentrations of KCl in the middle cerebral arteries, and in concentrations above 5 X 10(-5)M it attenuated the contractile response to high concentrations of KCl in the basilar and mesenteric arteries. The attenuation was greater in cerebral than in mesenteric arteries. The contractile response of cerebral arteries to high concentrations of serotonin was also attenuated by ketamine in concentrations above 5 X 10(-5)M. Ketamine attenuated KCl-induced contraction of cerebral arteries more than it attenuated serotonin-induced contraction. When basilar arteries were exposed to Ca2+-free media and depolarized by KCl, the addition of Ca2+ caused biphasic (transient and sustained) contractions, while in the mesenteric arteries the addition of Ca2+ produced sustained contractions. Ketamine at 5 X 10(-5) and 5 X 10(-4)M attenuated both transient and sustained contractions in basilar arteries, while in mesenteric arteries 5 X 10(-4)M ketamine attenuated only sustained contractions. In both instances, ketamine-induced attenuation was partially reversed by excess Ca2+. It is concluded that ketamine has a direct dilating effect on both cerebral and mesenteric arteries, but the effect is more pronounced in cerebral than in mesenteric arteries. The direct action of ketamine on those arteries may be due in part to interference with transmembrane influx of Ca2+.

Animals↗
PubMed1983

[Spontaneous occlusion of the circle of Willis--supplementary study: analysis of the disease process and proposal of a new concept, collateral arterial syndrome].

This disorder, because of its protean manifestation, had long been controversial until Kudo advocated it as a distinctive disease apart from other apoplectiform diseases. However, exact relationship between juvenile and adult types of this disease has been rather poorly understood. As the results of this study, authors concluded that this disease consists of two parts; initial and successive. Initial part corresponds to juvenile disease process and successive to adult process. The former is the well known peculiar slowly progressive occlusive process which originates at the terminal portion of the bilateral internal carotid arteries. The latter is the disease process which develops in collateral arterial plexuses produced by initial process characterized by hemorrhagic and occlusive attacks. Both attacks, hemorrhagic and occlusive, have been believed characteristic to adult patients. But this study disclosed not a small number of patients present hemorrhagic attacks in adolescence and some of them early in juvenile age immediately after ceasing initial process. As the cause of hemorrhage, rupture of miliary aneurysms, which have been discovered in 50% of juvenile patients and 85% of adult patients by magnifying angiography (Fukuda and Yamada) was anticipated. Authors proposed a new concept: collateral arterial plexus syndrome to specify a disease process which occurs in collateral arterial plexuses and presents hemorrhagic and occlusive attacks.

Adolescent↗
PubMed1982

Uptake of fat by fluorescent granular perithelial cells in cerebral cortex after administration of fat rich chow.

As reported previously, fluorescent granular perithelial cells (F.G.P.) are distributed along small blood vessels, possibly postcapillary venous vessels, in the cerebral cortex; these cells take up intraventricularly administered horseradish peroxidase efficiently. In this study it is shown that lipid substances of the blood are easily incorporated into F.G.P. and stored in their cytoplasm. The quantity of fat deposits in F.G.P. varies with the age of the animal and is very marked in old rats. The administration of elastase suppresses the fat uptake and/or facilitates the fat metabolism in F.G.P.

Aging↗
PubMed1982

Immunohistochemical demonstration of acid alpha-glucosidase in fetal rat hepatocytes and glycogenosomes of newborn rat hepatocytes.

The electron microscopic distribution of acid alpha-glucosidase in fetal and newborn rat hepatocytes was studied by a peroxidase labeled method. In fetal and newborn rat hepatocytes, acid alpha-glucosidase was found abundantly. The reaction products had a small granular appearance in each hepatic area under the light microscope. By electron microscopy, the enzyme was found to be located in the lysosomes, especially on the lysosome membranes, and sometimes within their contents. Glycogenosomes appearing in the hepatocytes obtained from newborn rats at 6 hours after birth showed a positive immunohistochemical reaction on their membranes and also within their contents. Furthermore, positive reactions were apparent on the Golgi apparatus in newborn rat hepatocytes. These results indicated that the glycogenosomes appearing in the early neonatal rat hepatocytes did not depend on a deficiency of acid alpha-glucosidase.

Animals↗
PubMed1982

Immunohistochemical localization of acid alpha-glucosidase in rat liver.

Acid alpha-glucosidase (E.C. 3.2.1.3) was purified more than 60,000-fold from rat liver. Antibody was obtained by injection of this pure enzyme into rabbits with Freund's complete adjuvant. The resultant anti-acid alpha-glucosidase immunoglobulin (Ig) G was digested with pepsin and then F(ab')2 was treated with 2-mercaptoethanol. Coupling of Fab' to horseradish peroxidase was performed according to the method of Wilson and Nakane. Light microscopic observation of the immunohistochemical localization of this enzyme in rat hepatocytes revealed small granular deposits of diaminobenzidine reaction products. The reaction diffusely observed in the hepatocyte cytoplasm of any area. Under the electron microscope, the reaction precipitates were found to be located on the lysosome membrane, particularly on the inner side of the membrane, as small dots. The small vesicles were strongly positive for this reaction. Occasionally positive reaction were also demonstrated in the lumen of the secondary lysosomes. However, the Golgi and its associated structures did not show a positive reaction.

Animals↗