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Biomedical subjects

S Frenkiel

Publications and source records attributed to S Frenkiel.

64 records · Page 4Linked to original sources
PubMed1981

Multifactorial etiology of nasal polyps.

Forty patients with nasal polyps were assessed. Elevated serum total IgE levels in nine patients did not correlate with skin testing. Increased serum immune complexes were detected in 11 patients but did not correlate with depressed complement (five patients). Multiple immunological mechanisms may be involved in nasal polyp formation.

Airway Obstruction↗
PubMed1980

Relapsing polychondritis. A feature of systemic lupus erythematosus.

In summary, we have presented two well documented cases of SLE with relapsing polychondritis. The chondritis was not a presenting feature and had no obvious prognostic significance. Neither patient has developed any further manifestations of relapsing polychondritis. A local immune complex etiology may be suggested by the laboratory findings. Treatment with corticosteroids was associated with the resolution of inflammation within a few days. Relapsing polychondritis should be recognized as an uncommon feature of SLE.

Adult↗
PubMed1980

Persistent adenoid presenting as a nasopharyngeal mass.

A diagnosis of hypertrophied adenoid tissue was confirmed in 12 adults each investigated for a nasopharyngeal mass. The patients ranged in age from 17 to 64 and initially presented with either nasal obstruction or serous otitis media. Four patients had evidence of allergic disease. The development of the lymphoid tissue of Waldeyer's ring is reviewed. Although the adenoid is thought to regress in adolescence, it appears that it can remain hypertrophied and become symptomatic in adulthood. A thorough clinical investigation culminating in biopsy is essential to exclude more ominous pathology.

Adenoidectomy↗
PubMed1980

Upper airway obstruction in children. The value of inspiratory-expiratory flow-volume curves.

The physiological assessment of upper respiratory tract obstruction using inspiratory-expiratory flow-volume curves is a valuable non-invasive procedure in children. The technique employed at the Montreal Children's Hospital with appropriate case material is presented. Although flow-volume curves can reliably diagnose and localize a large airway obstruction, these lesions are readily monitored by spirometric testing.

Airway Obstruction↗
PubMed1977

Traumatic thermal injuries of the middle ear.

Eleven cases of thermal otic injury are reviewed. The final outcome of therapy, whether medical or surgical is poor--only two of 11 patients were restored to normal. The possible pathogenesis of failure is discussed. Most cases could have been prevented by wearing ear plugs.

Accidents, Occupational↗
PubMedDate not supplied

Congenital tracheal diverticulum. A case report.

A six-month-old female with a history of recurrent bronchopulmonary infections was admitted to the Montreal Children's Hospital in severe respiratory distress. Cardiac arrest ensued and although ventilation by mask was always possible during the resuscitation procedure, there was a confusing inability to aerate the lungs after successful intubation. A right-sided tracheal diverticulum was identified at autopsy. It was assumed, in retrospect, that the intubating tube entered and abutted against the wall of the diverticulum, thus obstructing its distal lumen. The embryology, morphology and pathophysiology of congenital tracheal diverticuli are discussed. This rare diagnosis should be entertained when successful intubation leads to ineffectual ventilation

Bronchopneumonia↗
PubMedDate not supplied

Septal deviation and chronic sinus disease.

The introduction of computerized tomography in the identification of sinonasal pathology and associated anatomic variants has contributed to a greater understanding of the factors leading to ostiomeatal complex (OMC) obstruction and chronic sinus disease. The OMC and paranasal sinus regions were prospectively evaluated in 150 consecutive patients as a function of the degree of nasal septal deviation and compared with matched controls. These data were correlated with paranasal sinus disease, lateral nasal wall findings, and middle turbinate abnormalities. An increased incidence and severity of bilateral chronic sinus disease was present with increasing septal deviations (p < 0.05). Similarly, patients with increasing nasal septum deviations were noted to have a higher incidence of OMC obstruction (p < 0.05). Ostiomeatal complex obstruction in the direction of septal angulation was associated with nasal septal deformity; however, contralateral OMC obstruction was associated with middle turbinate and lateral nasal wall abnormalities (p < 0.05). The evaluation of the degree of septal angulation has helped better understand the factors contributing to chronic sinus disease and OMC obstruction.

Adolescent↗