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Biomedical subjects

S Fabre

Publications and source records attributed to S Fabre.

At least 55 records · Page 3Linked to original sources
PubMed1987

[Comparison of the efficacy of cefotaxime alone and the combination cefazolin-tobramycin in the treatment of enterobacterial septicemia].

In a prospective, randomized study we compared cefotaxime (C) with tobramycin plus cefazolin (C + T) in the treatment of Enterobacterial septicemia. Twenty-five patients received C and twenty two C + T. There are 8 treatment failures, in C + T group, 3 in C group. We observed 5 adverse effects, 2 in the C group (1 reversible collapse and 1 Pseudomonas aeruginosa superinfection) and 3 in the C + T group (acute renal failures). We conclude that C may be more effective and less toxic than cefazolin plus tobramycin for patients with Enterobacterial septicemia.

Aged↗
PubMed1982

[Liver diseases associated with Yersinia infections (author's transl)].

Yersinia infections are exceptionally responsible for liver damage, the hepatic diseases most commonly encountered being liver abscess consecutive to Y. enterocolitica or Y. pseudo-tuberculosis septicaemia or, more rarely, hepatic granulomata or hepatitis with necrosis and cholestasis. Two new cases are reported. One patient had hepatic granulomata caused by Y. pseudo-tuberculosis and the other, necrotizing hepatitis caused by y. enterocolitica. The course of the disease was favourable in both cases.

Adult↗
PubMed1977

Management of bacterial infections in severely neutropenic subjects.

The safety and efficacy of tobramycin, a new aminoglycoside, have been evaluated in combination antibiotic therapy in 49 episodes of infection in 25 neutropenic patients. Tobramycin was used in combination with a cephalosporin in 40 episodes and with carbenicillin in 6. The most common infections were respiratory (21 episodes) and septicaemic (16 episodes). One or more pathogens were identified in 38 episodes, of which 36 were due to Gram-negative organisms. The clinical response was satisfactory in 71% of episodes, and the pathogens were eliminated in 50% of episodes in which follow-up bacteriological investigation was available. No renal, auditory, or vestibular toxicity was observed.

Adult↗
PubMed1977

[Toxic syndrome induced by neuroleptics: report of 7 cases].

Seven cases of malignant syndrom due to neuroleptic drugs are reported, three of them in patients receiving long-acting medication. The authors point out the seriousness of such accidents, two of seven cases leading to death. Clinical features consist mainly of hyperthermia which can be erroneously attributed to infectious disease. Muscular hypertonicity is often associated with hyperthermia. Tetanus was evoked for two patients. In the absence of satisfactory physiopathologic explanation, treatment is merely symptomatic, based on intensive care. So far, this type of accident has been little known; it was important to focus our attention on it.

Adult↗
PubMed1976

Tobramycin and cephalothin sodium in treatment of infected patients with acute leukemia.

Tobramycin has been shown to be safe and effective when given intravenously in combination antibiotic therapy for infected patients with acute leukemia or other profound pancytopenic states. Tobramycin in combination with one or more antibiotics (usually cephalothin) produced satisfactory clinical results in 21 of 30 episodes of fever. Toxic effects were minimal and were limited to occasional mild thrombophlebitis.

Acute Disease↗