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Biomedical subjects

S F Lin

Publications and source records attributed to S F Lin.

136 records · Page 8Linked to original sources
PubMed1981

Kinetics of trans-cinnamic anhydride reactions catalyzed by pyridine, 4-dimethylaminopyridine, and N-methylimidazole.

The kinetics of hydrolysis of trans-cinnamic anhydride and of its reactions with hydroxy compounds were studied in the presence of pyridine, 4-dimethylaminopyridine, and N-methylimidazole as catalysts. The absolute rates of the catalyzed hydrolysis decreased with increasing acetonitrile content (decreasing solvent polarity), but the catalytic efficiency of N-methylimidazole and 4-dimethylaminopyridine relative to pyridine increased as the solvent polarity decreased. The relative catalytic rates for the cinnamoylation of n-propanol in acetonitrile were 1:259:16,000 for pyridine, N-methylimidazole, and 4-dimethylaminopyridine, respectively.

Catalysis↗
PubMed1981

Clinical significance of antinuclear antibodies in systemic lupus erythematosus.

Sera from 70 patients with systemic lupus erythematosus were studied for antinuclear antibodies and its clinical significance. Indirect immunofluorescence technique with mouse liver tissue and Crithidia luciliae flagella as substrates was used to detect antinuclear antibodies (FANA) and antibodies to double-stranded DNA (anti-ds DNA), respectively. Double immunodiffusion method identical with reference sera was used to detect antibodies to extractable nuclear antigens (anti-ENA). The prevalence of fluorescence antinuclear antibodies, antibodies to ds DNA and antibodies to ENA were 95.7%, 52.9% and 58.6%, respectively. Patients with homogeneous pattern of FANA presented clinically with high incidence of LE cell phenomenon. Patients with anti-ds DNA antibodies presented clinically with high incidences of serositis, profuse proteinuria, low serum C3 and high clinical activity. Patients with anti-RNP antibodies presented with high incidence of Raynaud's phenomenon and low incidence of anti-ds DNA antibodies. Patients with severe renal involvement showed a good correlation with high titer of anti-ds DNA antibodies and low serum C3. Therefore, these two factors together are helpful to predict the severity of renal involvement at the time of serum sample was obtained.

Antibodies, Antinuclear↗
PubMedDate not supplied

Utilization of the aortic flap above the facing commissure in arterial switch operations.

BACKGROUND: The aortic flap above the facing commissure after removal of the coronary button from the aortic sinus can be utilized for reconstruction in an arterial switch operation. METHODS: The free flap was used to reconstruct the coronary artery in two cases, as a medially based trapdoor. A rotational flap was inserted into the cut-open right pulmonary artery to augment the neopulmonary arterial anastomotic site in another case. RESULTS: All patients are doing well at mid term follow-up. CONCLUSIONS: The indications of each method and reported tricks to avoid coronary artery kinking during an arterial switch operation are discussed.

Aorta↗
PubMedDate not supplied

Creation of a one-way interatrial communication in the treatment of critical pulmonary stenosis with intact ventricular septum: a case report.

BACKGROUND: In biventricular repair of pulmonary outflow tract obstruction with intact ventricular septum, the right ventricle is loaded with total pulmonary blood flow acutely as the right-to-left shunt is abolished by closure of the atrial septal defect (ASD). METHODS: We designed a one-way interatrial communication by creation of an atrial septal flap to reduce the excessive volume load of the right ventricle. RESULTS: This procedure was successfully performed in a 3-year-old girl undergoing definitive biventricular repair for critical pulmonary stenosis associated with tricuspid stenosis and a small right ventricle. CONCLUSIONS: We believe that creation of a one-way interatrial communication might be a good alternative to adjustable ASD and/or bidirectional Glenn shunt in biventricular repair of critical pulmonary stenosis or pulmonary atresia with intact ventricular septum.

Child, Preschool↗
PubMedDate not supplied

Clinical implications of short-axis aortopulmonary rotation on juxtacommissural origin of the coronary artery in transposition of the great arteries and surgical strategy.

BACKGROUND: The relationship of short-axis aortopulmonary rotation (APR) with juxtacommissural origin of the coronary arteries (JOCA) in transposition of the great arteries (TGA) has never been elucidated. The surgical outcome of arterial switch operation (ASO) is influenced by the presence of JOCA. METHODS: Fifteen patients with TGA who presented to our institution between 1988 and 1995, and 23 cases from the literature, all with documented JOCA and APR, were analyzed. Each coronary arterial type was assigned to one of five patterns, according to similarities of epicardial configuration. All our patients underwent an ASO with various techniques to deal with JOCA. RESULTS: JOCA near the facing commissure (FC, 35 cases), were more frequent with anterior TGA (29/31, 94%) except types 5cj and 9j that were seen with posterior and right lateral TGA (4/4, 100%); whereas JOCA near the right-hand nonfacing commissure (RNC, 3 cases) were related with posterior TGA. Eta-square analysis showed significant correlation between various JOCA and short axis APR. Thirteen of our cases had JOCA near FC, two near RNC. Five of the former in whom the coronary artery was excised as a single button had a superior trapdoor; using a two-button technique three of the former had a lateral funnel and one of the latter had a medial trapdoor for the JOCA; all survived although on late noncoronary death was noted. In the remaining six cases without augmentation, only one survived (8/1 vs 1/5, p < 0.02). CONCLUSION: JOCA in TGA was related to short axis APR, generally near FC in anterior TGA (except types 5cj and 9j), and near the RNC in posterior TGA. A superior (lateral) or medial flap, to augment the coronary button for JOCA near FC or RNC is helpful for a successful ASO.

Aorta↗
PubMedDate not supplied

Safety and efficacy of cefpirome in comparison with ceftazidime in Chinese patients with sepsis due to bacterial infections.

BACKGROUND: The safety and efficacy of cefpirome (CPM), a fourth-generation cephalosporin, has not yet been studied in an Asian population. METHODS: Sixty-nine adult Chinese patients with sepsis due to bacterial infections were enrolled in the study and randomly assigned to receive CPM (2 g i.v. every 12 h) or ceftazidime (2 g i.v. every 8 h). RESULTS: Both groups were comparable in terms of demographic, clinical and microbiological features. The causative pathogen was Escherichia coli or Klebsiella pneumoniae in the majority of microbiologically documented cases. The rates of clinical response (94 vs. 94%) and bacteriological response (65 vs. 68%) were similar in both groups. Similar adverse events, including rashes, gastrointestinal upset and asymptomatic elevation of hepatic enzymes, occurred in a minority of patients in both groups. All events were self-limited after discontinuation of the drugs. CONCLUSION: CPM is as safe and effective as ceftazidime in the treatment of sepsis due to bacterial infections in Chinese patients.

Adult↗
PubMedDate not supplied

MEQ and V-IL8: cellular genes in disguise?

One of the hallmarks of oncogenic viruses is their ability to subvert the growth regulation and evade immune response of the host. There are a number of tricks devised by various virus families. Oncogenic herpesviruses often accomplish this by encoding homologs of cellular genes involved in these functions. These viral homologs sometimes are hyperactive forms of their cellular counterparts, which function to overtake the cellular pathways, other times serve as decoys to mask the cellular functions. Marek's disease virus (MDV) carries at least two genes in that category. We have previously described Meq protein (MEQ gene product), a transcriptional factor with homology to proto-oncogenes Jun and Fos in the bZIP domain. Meq dimerizes with Jun or Fos and the Meq/Jun heterodimer is able to transactivate promoters with AP-1 site. We show here that Meq and Jun colocalize in living cells, adding to the physiological significance of the dimer formation. In addition, we present data to show that Meq and Jun can functionally complement each other in cis and in trans, using transformation and transactivation assays. Finally we describe the discovery of an IL8 chemokine homolog, designated as v-IL8 (viral IL8) in the MDV genome and discuss its possible function in MDV infection.

Amino Acid Sequence↗