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Biomedical subjects

S Eckhardt

Publications and source records attributed to S Eckhardt.

At least 109 records · Page 6Linked to original sources
PubMed1977

Uptake of labeled dianhydrogalactitol into human gliomas and nervous tissue.

The distribution of iv administered 3H-dianhydrogalactitol (DAG) in the plasma, cerebrospinal fluid (CSF), brain, and tumor tissue was studied in 11 patients. DAG entered the CSF and was slowly eliminated, with a half-life of 20 hours. Unchanged DAG accounted for about 6%-30% of the total radioactivity in the CSF. All the tumors accumulated the drug to a higher extent than the intact white matter, except the one meningioma studied. The highest uptake was observed in the relatively benign astrocytic tumors.

Adult↗
PubMed1977

Biopharmacological investigation of 6,6'methylene-bis/2,2,4-trimethyl-1,2-dihydroquinoline (MTDQ) a radical binding antioxidant of secondary amine type.

The evidence of free radicals in tumor tissue and the possibility of their experimental influencing by means of antioxidants justifies the search for new pharmacological groups of tumor inhibiting agents. The authors synthesized a sterically inhibited, heterocyclic, bifunctional, non-toxic radical binding antioxidant of secondary amine type. The structural change is interpreted with the possibility of recombination characteristic for secondary amine groups and the double chain closing effect. The conjugation effect secures mobility of the hydrogen atom. The compound contains 10 to 12 per cent dimer-trimer of higher biological activity than monomers, due to higher molecular weight. An additional pharmacodynamic advantage compared to hitherto known antioxidants consists in its lower vapour volutility and the biradicality.

Amines↗
PubMed1976

[Enzymologic investigations of Vx2-carcinoma transplanted into the stomach of rabbits (author's transl)].

Suspensions of V x2-carcinoma cells were inoculated into the stomach wall of rabbits. In 26 animals, changes of lactic acid hydrogenase (total activity and isoenzyme distribution) were followed from the transplantation day to complete development of a tumor. Findings were compared with mucosa specimen taken from different parts of the stomach. As compared with control animals (injection of physiological saline solution into the stomach wall), total enzyme activity was elevated and isoenzymes showed characteristic distribution in homogenisates from tumorous tissue. Mucosa covering the tumor did not reveal such alterations of enzyme activity. It can thus be concluded that V x2 carcinoma was limited to submucosal layers and did not invade the mucosa. This conclusion was confirmed by histologic examination.

Animals↗
PubMed1976

[Evaluation of lymphography in neurologic complications of neoplastic diseases (author's transl)].

1. By lymphographic examination, first of all, the primary and secondary tumours of the lymphatic system may be revealed and localized. Further on, it makes possible to state the stage of the disease and thus to apply the appropriate treatment. 2. In case of symptoms indicating that nerve-roots of unknown origin have been damaged, the result of lymphographic examination may call the attention to pathomechanism related to some tumour-disease. If the symptoms of the nervous system are caused by compression or infiltration of a tumour, most frequently the presence of pathologic lymph nodes in their surroundings can be revealed. 3. Among the patients of the National Oncological Institute, in 25 Hodgkin and 2 cases pathologic filling of the lymphatic system was observed by lymphographic examination, -- in 4 cases in the surroundings affected by the damage of the spinal cord while in 23 cases in that of nerve-root. If a tumour disease is discovered and localized in time by lymphographic examination, the symptoms caused by it in the nervous system may be reduced, or, seldom, even alleviated, with a treatment of directed irradation combined with cytostatics. The favourable effect on alleviating pains is to be especially emphasised.

Adolescent↗