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Biomedical subjects

S Diallo

Publications and source records attributed to S Diallo.

At least 91 records · Page 5Linked to original sources

[Evaluation of the sensitivity of Anopheles gambiae to fenitrothion, malathion and DDT in Senegal].

Routine tests of the susceptibility of the female of the A. gambiae complex have been carried out with Fenitrothione, Malathion and DDt in four senegalese regions. Discriminative doses of these insecticides were used with variable exposure times on unfed females caught in houses. A gambiae s. 1 showed normal susceptibility to Fenitrothion and Malathion. With DDT, the results were variable and resistance was observed in Dakar and Kolda.

Animals↗

[Evaluation of the efficacity of PESGUARD-PS 201 ultra low volume (ULV) spraying against mosquitos in the Pout area (Thies, Senegal)].

In September 1989, four weekly ULV applications of PESGUARD-PS (Pyrethroid) with SEMCO car mounted ULV aerosol generator in Pout (Thiès, Sénégal) were ineffective against adult populations of Anopheles arabiensis, Culex quinquefasciatus and others culicines. No decrease in the mosquito populations was observed both indoor and out door in the test area.

Animals↗

Application of multiple methods to study the immunization programme in an urban area of Guinea.

During 1988-89, studies were conducted to evaluate the immunization system in Conakry, Guinea. The first, a health facility survey, found that health staff screened the vaccination status of only 30% of children who presented for curative care. A sterile syringe and needle were used for less than half of the injections. In the second survey, key informant interviews with vaccinators and health centre chiefs showed that there were minimal lines of communication between health workers and the community, but that health workers did not perceive this to be a problem. Focus group discussions in the community revealed a high level of general knowledge about vaccine-preventable diseases. However, mothers did not know how many vaccinations their children should receive or by what age they should be completed. They complained of long waiting times in health centres, the high costs of vaccination, poor rapport with health workers, and the occurrence of abscesses after vaccination. The final study, a "knowledge, attitudes, and practice" community survey, showed that missed immunization opportunities and inappropriately timed vaccinations reduced potential vaccine coverage by almost 30% among children with vaccination cards. Higher socioeconomic status, delivery in hospital, and whether mothers perceived the vaccinations to be affordable affected whether the child began the immunization series. Once a child had entered the immunization system, completion of the series was determined by the mother's education level, employment status, and experience with vaccination services.

Adult↗

[The emergence of chloroquine-resistant malaria in Dakar, Senegal].

In October and November 1988 we carried out in vivo Plasmodium falciparum sensitivity tests for chloroquine in the town of Dakar, where malaria is endemic with increased transmission during the rainy season (July to October). 25 mg/kg/p.c of chloroquine has been administered to 35 patients on three consecutive days, according to the WHO protocol. Clinical and parasitological controls were carried out on D1, D2, D3, D4, D7 and D14. We observed two therapeutic failures: one on D7 among the 32 patients examined during that period, and one on D14 among the 24 patients who were present at control. The important drug pressure and population movements in Dakar are sources of chloroquine resistance which should receive special attention in terms of control and surveillance of this emerging problem.

Adolescent↗

[Factors of humoral and cellular immunity in onchocercosis (results of studies conducted in Senegal)].

In the course of Onchocerca volvulus infection in subjects with from light to heavy microfilarial count in skin snips occurred important alterations concerning both humoral and cell-mediated immunity. Serum examination for immunoglobulins showed high synthesis of IgG, IgM and IgE. The level of IgM was found to be correlated to the intensity of the infection, an important reduction of T4 cells was observed and is associated with hyporeactivity to in vitro stimulation to phytohemagglutinin A (PHA). The considerable loss seen in T4 cells function could lead to a reducing of cell-mediated immune mechanisms and humoral response needed in the acquisition of resistance.

Adult↗

A double-blind comparison of the efficacy and safety of ivermectin and diethylcarbamazine in a placebo controlled study of Senegalese patients with onchocerciasis.

Ivermectin (MK-933) has been compared with diethylcarbamazine (DEC) and placebo in a double-blind study in 30 adult male Senegalese patients with Onchocerca volvulus infection. 10 patients were randomly assigned to each treatment group. Ivermectin was administered as a single oral dose of 12 mg and DEC as 50 mg daily for two days and 100 mg twice daily for the following six days, total 1.3 g in eight days. Skin O. volvulus microfilaria densities remained near pre-study values in the placebo patients, but decreased rapidly with both active drugs to mean values about 2% of pretreatment (Day 8) and then increased slowly, reaching in 12 months about 4% of pre-treatment (ivermectin) and 18% (DEC). This difference is statistically significant. Clinical adverse reactions were recorded in four ivermectin, ten DEC and three placebo patients. One ivermectin and six DEC patients received steroid treatment for relief of these reactions. Serious adverse ocular changes were not seen in any patients, possibly because of the steroid therapy in the DEC patients. Adult O. volvulus from onchocercal nodules one and six months after treatment showed no effect of either drug on viability. Intra-uterine developing forms of the microfilariae appeared normal in all three treatment groups at the one month examination but deformed and degenerated forms were evident at six months in the ivermectin group but not in the DEC and placebo patients. Ivermectin as a single oral dose appears to be a safer and more effective microfilaricidal drug in human onchocerciasis than DEC in the standard multi-dose regimen.

Adolescent↗

[T-cell subpopulations during acute attacks of pernicious malaria].

The distribution of T-cell subsets in acute and cerebral malaria have been studied using two monoclonal antibodies. In the course of the disease both in acute and cerebral malaria in persons living in senegalese hypoendemic area occurred important alterations of circulating T-cell subsets. A significant loss of OKT4 positive cells is observed; OKT8 positive lymphocytes are also affected but to a lesser extent. The reversal of the OKT4/OKT8 ratio found in this disease is associated with decrease responsiveness of lymphocytes to PHA. The considerable loss seen in OKT4 cells fonction could be of great importance in reducing cell mediated immune mechanisms and humoral response needed to eradicate the malaria parasite.

Acute Disease↗