The future of gynaecological oncology in Spain.
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Biomedical subjects
Publications and source records attributed to S Dexeus.
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On the basis of our experience, we regard hysteroscopy as an important step in oncological propedeutics whenever performed by doctors of an endoscopic unit having experience of the subject. We believe it has a very important role in differential diagnosis of uterine bleedings, in the correct classification of endometrium carcinomas and in the control of non surgical treatments of endometrium carcinomas. It will be increasingly used in specialized hospitals.
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This study was designed to establish the role of microsatellite instability (MSI) in the development of sporadic tumors of the ovary. The instability of 6 microsatellites (BAT25, BAT26, NME1, D17S250, D5S346 and D2S123) was determined by comparing MSI in healthy and tumoral tissue in each of 40 patients undergoing surgery for a sporadic ovarian tumor. BAT26 and D2S123 instability was detected in borderline tumors, and ovarian carcinomas were found to present instability in the microsatellites BAT25, NME1 and D17S250. Our findings indicate that microsatellite instability lacks a significant role in the appearance or progression of sporadic ovarian tumors.
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