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Biomedical subjects

S Day

Publications and source records attributed to S Day.

At least 127 records · Page 7Linked to original sources

The development of performance and cost indicators for preschool immunisation.

The organisation, premises, and staffing of three child health clinics of different types in an inner city area have been studied and related to information on immunisation derived from their computerised child register and other returns, together with some simple estimates of cost. Differences were found between overall uptake of different antigens, consent rate, compliance after consent had been given, and the median age at immunisation for children allocated to each clinic. Thus consent to pertussis immunisation varied from 90% in one clinic to 69% in the other two. In the clinic with the high consent rate, however, only 66% of those whose parents had consented actually received all three doses compared with 82% and 85% in the other clinics. The median age of immunisation also showed pronounced differences between the clinics--314, 351, and 375 days, respectively, for the third dose of the triple course. There were differences in characteristics of the clientele served by each clinic and in staffing and facilities, which led to differences in costs, as well as contributing towards the variable patterns of uptake. We suggest that indicators such as these, largely available from the child health computer system, are used systematically to identify ways of improving uptake and increasing cost effectiveness.

Ambulatory Care Facilities↗

Distribution of joint mobility in a normal population: results of the use of fixed torque measuring devices.

Fixed torque measuring devices were used to measure the range of movement at three sites in 364 normal adolescents and young adults. The results confirm the findings of less reproducible measurement techniques that joint mobility at a particular site follows a Gaussian distribution with a wide range in a normal population. In addition, apart from very few individuals, mobility at one site could not predict mobility elsewhere. It seems likely that the degree of connective tissue laxity generally is of lesser importance than local factors in determining the range of joint mobility at a given site in normal individuals.

Adolescent↗

Mother-infant activities as providers of sensory stimulation.

A descriptive study was conducted to determine types and amounts of stimulation to five sensory systems of an infant that occurred as a result of everyday mother-infant activities. The infant studied was between 4 and 6 weeks of age. Results demonstrated that, overall, the baby received more tactile stimulation than any other type, followed by proprioceptive, auditory, visual, and vestibular stimulation. When activities were compared on a daily basis, feeding was found to provide the greatest amount of stimulation followed by playing, holding/carrying, bathing and changing. When compared on a per minute basis, playing was found to provide more stimulation than any other activity, followed by holding/carrying, bathing, changing, and feeding. The manner in which the various activities were carried out had a strong influence on the types and amounts of stimulation that resulted. Characteristics of both the infant and the mother appeared to be important influences on the types and amounts of stimulation the infant received. It was concluded that both mother and infant should be considered in planning therapeutic programs.

Acoustic Stimulation↗

Characterization of the phagocytic cells isolated from the human placenta.

The present study has shown that the human placenta (first trimester and full term) contains a significant population of mononuclear cells (isolated by proteolytic treatment) expressing receptors for Fc(IgG) and C3 and bearing surface immunoglobulin that is probably cytophilic. The cells, as assessed by morphology, resemble macrophages and actively partake in both immune and nonimmune phagocytosis. The receptor and phagocytic characteristics of the placenta suggest that it may be regarded as an important compartment of the reticuloendothelial system and that these properties probably contribute significantly to its defensive role in utero.

Erythrocytes↗

The eye as a sanctuary in acute lymphoblastic leukaemia.

Leukaemic infiltration of the anterior chamber of the eye was the only sign of relapse in two children with acute lymphoblastic leukaemia who had been off treatment for two and four months. The malignant cells had probably been present in the eye since the onset of the disease.

Anterior Chamber↗

Evaluation of an improved rapid coagglutination method for the serological grouping of beta-hemolytic streptococci.

Grouping of beta-hemolytic streptococci was performed with the Phadebact Streptococcus Test, a coagglutination method, and the results compared with serological grouping by the standard Lancefield precipitin method. Of 171 clinical specimens examined, 169 (98.8%) were grouped correctly by the Phadebact Test after 24 h of continuous growth in Todd-Hewitt broth. In a parallel study, 96.9% of specimens that grew after only 4 h of incubation in broth were grouped correctly by the coagglutination method. In both studies, the accuracy of the coagglutination test was increased significantly by elimination of multiple-agglutination reactions through centrifugation of cultures and utilization of the supernatant fluid in the Phadebact Test.

Agglutination Tests↗

Explanations for weight loss after ileojejunal bypass in gross obesity.

Twenty grossly obese patients underwent ileojejunal bypass operations. Measurements of calories lost in faeces showed that the malabsorption could not account for the weight loss. Furthermore, the malabsorption was not decreased two years after bypass, when weight was no longer being lost. Dietary restriction is therefore largely responsible for the weight loss and increased food intake for weight maintenance.

Body Weight↗

Plasma potassium changes following suxamethonium and suxethonium in normal patients and in patients in renal failure.

Fifty-four healthy patients and 21 patients with chronic renal disease received either suxamethonium 100 mg or suxethonium 150 mg for neuromuscular blockade during endotracheal intubation. A significant increase in plasma potassium concentration was observed following the administration of suxamethonium. No increase occurred in patients who received suxethonium. It is concluded that suxethonium may be preferable to suxamethonium in patients who are at risk from an increase in the plasma potassium concentration.

Adult↗

Effect of changes in feeding schedule on the diurnal rhythms and daily activity levels of intestinal brush border enzymes and transport systems.

The activities of rat intestinal enzymes, sucrase, lactase, maltase, trehalase, gamma-glutamyltransferase, leucylnaphthylamide-hydrolyzing activity, and the transport system for glucose follow diurnal rhythms on ad libitum and restricted feeding regimes. In response to 6 days of restricted feeding, food available between 1400 and 1800 Eastern Standard Time, all rhythms shifted in time and the daily levels of activities were changed. Alkaline phosphatase activity followed a diurnal rhythm only in restricted fed animals. In restricted fed rats several activity patterns were observed, some with short periods of maximum activity, 3 h or less, and some with plateaus of maximum activity, 5-9 h long. In respect to the time of day of the synchronizer, sucrase peaked before feeding, glucose transport peaked during feeding, alkaline phosphatase peaked after feeding, and the other enzymes had higher levels of activity before, during and after feeding. The effect of restricted feeding on the daily activity levels were: a decrease in leucylnaphthylamide-hydrolyzing activity, no change in alkaline phosphatase, and increases in the others. These enzyme and transport systems exhibit a large amount of individual regulation or control as reflected by the lack of a uniform activity pattern and response to the synchronizer, and the variation in direction and magnitude of the adaptations to restricted feeding.

Alkaline Phosphatase↗

Treatment of gross obesity by jejunal bypass.

Jejunal bypass operations were performed on 47 grossly obese patients. The results were disappointing in three patients who had a standard "14 in/4 in" Payne and DeWind procedure and therefore a more radical operation was performed, joining four inches (10.2 cm) of proximal jejunum to 10 inches (24.4 cm) of terminal ileum. Two years after the modified operation a mean of 44.2 kg had been lost and the weight tended to stabilize. This weight loss was due mainly to inadequate calorie intake. The appetite became more controlled so that if weight was regained this was small in amount. Metabolic sequelae and their symptoms also settled by two years. The physical, psychological, and social outcome was good. The postoperative period was stormy and required close medical and psychiatric supervision. There were two deaths.

Adult↗