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Biomedical subjects

S Das

Publications and source records attributed to S Das.

At least 685 records · Page 38Linked to original sources
PubMed1980

Structural changes in the kidney of freshwater mud eel Amphipnous cuchia (Ham.) subjected to different osmotic conditions.

A histophysiological study was made of the kidney of Amphipnous cuchia subjected to different osmotic conditions (distilled water, 50% and 15% sodium chloride solution). These fish possess typical glomerular kidneys having nephrons composed of a glomerular body, neck segment, proximal convoluted segment (I & II), distal segment, and collecting duct system. When subjected to a hypotonic medium (distilled water) the fish show marked expansion in glomeruli resulting in 'glomerulitis'. A marked shrinkage in glomerular body tissue is found after 50% salt solution treatment and the fish die within one hour of immersion. Many pathological changes occur in the renal capsule and renal segment when the fish are treated with 15% salt solution. The glomerular bodies show shrinkage, degeneration and cyst formation. The glomerular shrinkage is probably due to constriction of arterioles which affects the filtration rate and thus protects against loss of water. Formation of cysts could be a protective device to save the glomeruli from degeneration. The renal tubules show hypertrophy, vacuolization, nuclear degeneration and cyst formation.

Anguilla↗
PubMed1979

Effects of preliminary normothermic flushing on hypothermic renal preservation.

Flushing of harvested kidneys with hypothermic perfusates is presumed to cause inappropriate circulation due to vasospasm. Effects of initial normothermic flushing prior to hypothermic flushing and cold preservation were tested in canine kidneys. Analysis of the perfusion characteristics revealed that a brief initial flushing with solutions at 37 degrees C. eliminates vasoconstriction and even facilitates subsequent hypothermic flushing. In amounts not exceeding 100 cc. it was not deleterious to transplant function. Larger volumes of normothermic flushing were proved to cause endothelial injury and resulted in poor transplant survival.

Animals↗
PubMed1979

In situ flushing of donor kidneys: its technique and rationale.

In situ flushing of kidneys through an isolated segment of aorta was done on mongrel dogs. The 500 cc cold perfusate at 3 to 4C (delivered in 6 minutes) effectively cooled the kidneys to about 15C. This simplified technique of in situ flushing, its usefulness and rationale are discussed.

Animals↗
PubMed1979

Renal failure owing to oxalate nephrosis after jejunoileal bypass.

Oxalate nephrosis resulted in progressive renal failure in 4 patients after jejunoileal bypass for morbid obesity. In general, increased levels of oxalates in the blood and urine of such patients result from enhanced absorption of exogenous oxalates. Urinary calculous formation is determined further by concomitant deficiency of inhibitor substances, whereas oxalate nephrosis probably occurs as a result of oxalate deposition in renal interstitium via the blood stream. Clinical manifestations of oxalate nephrosis include pain, infection, hematuria and renal failure. Routine postoperative renal function studies and early renal biopsy in suspicious cases are urged to establish early diagnosis. Continued deterioration of renal function, despite therapy with oxalate restruction and oxalate binding agents, indicates a reversal of the bypass to preserve unaffected renal substance.

Adult↗
PubMed1979

Measurements of the dead space volume.

The "anatomical" dead space is commonly measured by sampling an inert gas (N2) and volume in the exhalation following a large breath of oxygen (VD(F)). It may also be measured from an inert gas washout (VD(O)) that describes both volume and the delivery of VD(O) throughout the expiration. VD(O) is known to increase with age and is enlarged in some obstructive syndromes. VD(O) was appreciably larger than VD(F) in our normal subjects. Both measures increased with lung volume, the increase being entirely due to an increase in the volume of phase I. Physiological dead space (VD(p)) however, did not change significantly with lung volume, showing "alveolar" dead space to diminish as a result. An increase in VD(O) occurred with increasing respiratory frequency that was explained by the increase in volume of phase I. Although an increase in VD(F) occurred with frequency, this was significantly less than that seen by VD(O), i.e., VD(F) did not see the progressive increase in phase I volume with frequency. No lung volume or frequency changes, parasympatholytic or sympathomimetic drugs, or altered patterns of breathing simulated the late delivery of dead space seen in age and some obstructive syndromes.

Aging↗
PubMed1979

Tunica vaginalis autografting for Peyronie's disease: an experimental study.

Groups of dogs were studied at varied intervals after autografting of tunica vaginalis from the testes to cover excised patches of tunica albuginea of the penis. Postoperative cavernosography revealed neither ballooning nor chordee. Histologically, the grafts were well accepted and uniformly merged with the neighboring collagen tissues at 6 months. We propose that tunica vaginalis would be ideally suitable for autografting to the penis after excision of Peyronie's plaques.

Animals↗