The compound 2,3-dimethyl-6(2-dimethylaminoethyl)6H-indolo-(2,3-b)quinoxaline (B-220) has been shown to exhibit potent antiviral activity against herpes simplex virus type 1 (HSV-1), varicella-zoster virus (VZV) and cytomegalovirus (CMV). The mechanism of antiviral action of B-220 against HSV-1 has been studied; from the results it appears that B-220 binds by intercalation into the DNA helix and then disturbs steps that are vital for viral uncoating.

Adsorption↗

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An unusual fetal complication of traumatic uterine rupture.

Rupture of the gravid uterus is reported in less than one percent of women involved in motor vehicle accidents. A 22-year-old nulliparous woman at 22 weeks gestation was involved in a motor vehicle accident. Evaluation revealed a uterine rupture with complete expulsion of placenta and decapitated fetus. Prompt surgical intervention and control of hemorrhage allowed preservation of fertility.

Accidents, Traffic↗

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The big-bang-for-your-buck theory.

Do it right, and your investment in information technology can have all sorts of strategic payoffs. Do it wrong, and you'll be paying, dearly, for nothing. Here's a guide to evaluating IT and measuring its impact.

Budgets↗

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Bilateral simultaneous patellar tendon rupture in a female collegiate gymnast. A case report.

Explore the source record for details and available documents.

Adult↗

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Managing health and safety in hospitals.

This article is set against the background of recent changes in health and safety legislation which directly affect hospital staff. Research into the central concepts of hazard, risk and harm is contributing to a broader understanding of the management of health and safety. Both occupational medicine and safety practice must recognise the role of psychosocial and organisational processes in managing workplace hazards.

Humans↗

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