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S Chopra

Publications and source records attributed to S Chopra.

187 records · Page 11Linked to original sources

Sonographic findings in cases of missed gallstones.

UNLABELLED: PURPOSE. We retrospectively evaluated sonographic findings in 946 cases of gallstones to determine whether the false-negative rate for gallstone detection by sonography has decreased as a result of technologic advances over the past 15 years. METHODS: We reviewed preoperative sonographic reports, operative notes, and pathologic reports for 614 women and 332 men (ages 22-78 years) seen over a 2.5-year period and compared sonographic findings with surgical pathologic findings after cholecystectomy. Sonograms for patients whose gallstones were missed on sonography were reviewed by 3 board-certified radiologists. RESULTS: Preoperative sonography of the gallbladder accurately predicted the presence of gallstones in 934 cases (98.7%). Gallstones were not identified by sonography in the remaining 12 cases. In those cases, sonography revealed polyps in 5, sludge in 5, sludge plus a polyp in 1, and neither stones nor polyps in 1. Thus, the false-negative rate was 1.3%. CONCLUSIONS: Despite improvements in sonographic technology, detection of small gallstones remains difficult in some cases. Adherent gallstones can mimic gallbladder polyps. Our false-negative rate for detection of gallstones was no different from that in earlier studies.

Adult↗

Hepatitis B due to transfusion of mislabeled blood.

Transfusion of a misidentified and mislabeled unit of hepatitis B surface antigen (HBsAg)-positive blood was recognized 18 hours after the transfusion episode. Within 24 hours of transfusion the recipient became HBsAg-positive, and antibody to the hepatitis B core antigen (anti-HBc) was detected. Despite hepatitis B immune globulin (HBIG) administration of 28 hours after transfusion, the serologic markers persisted for at least one month. Clinically apparent hepatitis developed about two months after transfusion. At this time HBsAg could not be detected, but antibody to HBsAg (anti-HBs) was present and anti-HBc persisted. The recipient recovered and became a plasmapheresis donor for several hepatitis B research programs.

Aged↗

Primary papillary serous carcinoma of the peritoneum: CT-pathologic correlation.

We present the CT findings of three cases of primary papillary serous carcinoma of the peritoneum. All patients presented with massive ascites. CT of the abdomen and pelvis showed omental caking in all patients. The parietal peritoneum of the pelvis showed diffuse enhancement with nodular thickening in all patients. No calcification was noted in the omental and parietal peritoneal masses, although psammoma bodies were present microscopically in one case. The ovaries were normal in size but showed a fine enhancing surface nodularity similar to the pelvic peritoneum. The CT findings of primary papillary serous carcinoma of the peritoneum are nonspecific, but this diagnosis should be considered when peritoneal carcinomatosis is seen on CT with normal-sized ovaries in the absence of other primary malignant neoplasms.

Aged↗

Hepatitis vaccines.

Viral hepatitis accounts for substantial morbidity and mortality worldwide, To date, the molecular sequences of six hepatotropic viruses have been described and designated hepatitis A, B, C, D, E, and G. Various methods have been employed to decrease the occurrence of these diseases, and advances in vaccination strategies have aided in prevention of viral hepatitis. There are currently two FDA-approved vaccines licensed for use in the United States, aimed at eradication of hepatitis A and hepatitis B viral infection. A considerable amount of research has been devoted to the development of these vaccines, and progress has been made toward the development of vaccines aimed at the other hepatotropic viruses. In this article, the development and current status of the vaccines directed against the hepatitis viruses are reviewed.

Flaviviridae↗

Effect of antibiotics in controlling the production of cell wall degrading enzymes in vitro and disease development in vivo.

Production of cellulolytic, proteolytic and pectolytic enzymes by all the three isolates of A. niger was inhibited by all the tested antibiotics. Nystatin (500 ppm) could cause complete inhibition of PG enzyme production, whereas PMG production was checked by amoxicillin, nystatin, chloramphenicol and raficillin at 100 ppm concentration. All the antibiotics at 500 ppm concentration checked the cellulase production in all the three isolates of A. niger. Nystatin and raficillin (100 ppm) completely controlled the protease production in all the three isolates of A. niger. A positive correlation was observed with enzyme production and mycelial biomass in three isolates of A. niger, All the antibiotics at both the concentrations (100 and 500 ppm) could also check the rottening in all the three fruits in vivo conditions.

Anti-Bacterial Agents↗