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Biomedical subjects

S Chandrasekar

Publications and source records attributed to S Chandrasekar.

At least 55 records · Page 3Linked to original sources
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Systolic time intervals in diabetes mellitus.

Systolic time intervals (STI) were evaluated in 45 diabetics without any cardiac signs and symptoms in order to study the left ventricular function. The STI parameters revealed an impairment of left ventricular function, thus implying preclinical myocardial involvement. This left ventricular dysfunction was more marked in patients in poor metabolic control and in cases with evidence of microangiopathy in kidney and retina, thus favoring the view that the primary myocardial disease is the result of metabolic and vascular components. Significant improvement in STI parameters was observed when good metabolic control was achieved, thus indicating that strict metabolic control is indeed worthwhile.

Age Factors↗
PubMedDate not supplied

Antipyrine metabolism in patients with diabetes mellitus.

1. A pharmacokinetic study of antipyrine was performed in healthy volunteers and diabetic subjects, ten in each group. After a single oral dose of antipyrine (18 mg/kg) multiple samples of saliva were collected for the determination of antipyrine concentration and a pharmacokinetic analysis was carried out. 2. The mean salivary half-life of antipyrine was found to be significantly higher in patients with uncontrolled diabetes as compared to the healthy subjects. However, there was no significant difference in volume of distribution and metabolic clearance rates. 3. After 15 days of insulin therapy, there was a significant reduction in the mean half-life of antipyrine in the diabetic patients. The mean half-life of antipyrine in the patients with controlled diabetes was not significantly different from that of the normal healthy subjects. 4. There was no significant correlation between the salivary half-life of antipyrine and a 2 hour postprandial blood sugar level in the diabetic patients. 5. Our data suggest impaired hepatic microsomal enzyme activity in patients with uncontrolled diabetes which was corrected after 15 days of insulin therapy.

Adult↗