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Biomedical subjects

S C Werner

Publications and source records attributed to S C Werner.

At least 37 records · Page 2Linked to original sources
PubMed1970

Circulating immonoglobulin M: increased concentrations in endemic and sporadic goiter.

Increased concentrations of immunoglobulin M have been found in the circulation of approximately half of patients with either endemic or sporadic nontoxic goiter. Blood was obtained from patients in several iodine-deficient goitrous areas; the patients with sporadic goiter resided in or about New York City. Concentrations of immunoglobulins G, A, and D were normal. Blood for control purposes was taken from patients residing in cities near the goiter areas where there was no iodine deficiency, and in New York City. Most of these samples came from hospitalized patients without known thyroid disease and were collected at random. Chi-square values for the difference between the number of goitrous patients with elevated concentrations of immunoglobulin M and those in the control patients were highly significant statistically.

Ecuador↗
PubMed1968

The thyroid.

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Age Factors↗
PubMed1967

Materials indistinguishable from iodotyrosines in normal human serum and human serum albumin.

Materials indistinguishable from authentic mono- and diiodotyrosines were identified in extracts of normal human serum as well as in extracts of purified human serum albumin. These materials were not found in association with the other serum proteins. Identification of MIT and DIT was made by a technique using rechromatography to constant specific activity, as well as by the Barker wet ash distillation method, which established the compounds in question as being iodinated ones. By two different extraction and chromatographic methods we estimated the amounts of both MIT and DIT present in normal human serum or albumin; the estimates were in good agreement. These compounds together constituted between 19% and 25% of the extractable serum iodine.

Chromatography, Thin Layer↗
PubMed1967

Total and free triiodothyronine in human serum.

A reliable method has been developed for the determination of total serum T3, dialyzable fraction (DFT3), and absolute concentration of free T3 (AFT3). Total T3 values (mean +/- SD) were: healthy euthyroid subjects, 0.33 +/- 0.07 mug per 100 ml; hyperthyroid patients, 0.71 +/- 0.1 mug per 100 ml; hypothyroid, 0.10 +/- 0.03 mug per 100 ml. Values (mean +/- SD) for DFT3 in these groups were 0.46 +/- 0.14%, 0.78 +/- 0.17%, and 0.16 +/- 0.08%, respectively. Calculated values for AFT3 were: 1.51 +/- 0.4 mmug per 100 ml, 5.00 +/- 0.6 mmug per 100 ml and 0.24 +/- 0.1 mmug per 100 ml, respectively. Dilution of serum before dialysis lowered estimated DFT3 values. Enrichment of serum with labeled T3 in the range examined did not affect DFT3. However, DFT3 was increased by addition of Merthiolate to serum in concentration 1: 10,000 due to displacement of T3 from thyroxine-binding globulin to albumin. The data suggest that triiodothyronine may play a considerably more important role in normal and pathological physiology, as evidenced by kinetic analysis using these data. A metabolic role for T3 equal to that of T4 is indicated.

Journal Article↗