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Biomedical subjects

S C Werner

Publications and source records attributed to S C Werner.

At least 19 recordsLinked to original sources
PubMed1979

Graves' disease following acute (subacute) thyroiditis.

The development of Graves' disease with positive thyroid-stimulating antibody titers is described in a woman, five months after onset of the putatively viral disorder, acute (subacute) thyroiditis. There was no evidence of transient hyperthyroidism during the acute episode. The arguments for and against a causal relationship between the two diseases have been reviewed. The present experience adds to the earlier suggestion that the association may represent cause and effect.

Acute Disease↗
PubMed1977

Modification of the classification of the eye changes of Graves' disease.

The original (1969) classification of the Eye Changes of Graves' Disease has been retained except for Classes 1 and 3. Class 1 has been limited so that proptosis of 23 mm or greater is placed in Class 3, even if the patient is asymptomatic. Grading of Classes 1 and 2 has been left to the individual physician or clinic, but we urge that the suggested criteria for grading Classes 3 through 6 be used. Progression of disease is not necessarily sequential through each of the classes, and ethnic factors and myopia may influence the extent of proptosis in normal subjects.

Eye Diseases↗
PubMed1976

Similar serum IgM concentrations in Greek endemic goiter and control populations: failure to confirm previous experience.

Circulating immunoglobulin M (IgM) concentrations were determined in 47 nontoxic goiter patients from four Greek endemic goiter areas, and in 13 patients from Athens, a non-goitrous area; and compared with 38 control non-goitrous subjects from the same goiter regions, and 23 more controls from Athens. The values in both goitrous and non-goitrous groups were indistinguishable. Current techniques for single radial immunodiffusion were employed. The results are expressed in standardized international units/ml serum, instead of the formerly used mg/dl. The present findings are in disagreement with the earlier observation from this laboratory that 40 per cent of goitrous patients had elevated IgM values compared with 10 per cent of control subjects.

Adolescent↗
PubMed1975

Excessive thyrotropin concentrations in the circulation of the spontaneously hypertensive rat.

Thyroid funct-on in SHR was compared to that of inbred normotensive Wistar rats from Kyoto, and random bred Wistar rats from the United States. A marked increase in circulating thyrotropin concentration was found in SHR compared to controls. Serum thyroxine and T3 concentrations relative to controls, however, were variable and the concentrations in male and female SHR relative to Kyoto controls did not correspond with each other. No ready explanation for the circulating excess of thyrotropin, with mimimal increase in T4 and T3 concentrations, is available.

Animals↗