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Biomedical subjects

S Brady

Publications and source records attributed to S Brady.

At least 55 records · Page 3Linked to original sources
PubMed1993

Noninvasive measurement of cervical tri-planar motion in normal subjects.

An electronic digital inclinometer was used to obtain normative data on cervical mobility from 58 normal subjects. They consisted of 28 males (age range, 17-61) and 30 females (age range, 19-62). The measurements were taken from occiput to T1 in flexion-extension, lateral bend, and axial rotation, isolating the regional motion by measuring simultaneously the upper and lower margins of the eight mobile segments. A comparison of radiographs and inclinometer measures showed excellent correlations (r < 0.9997, P < 0.05). Normative data are presented. Gender-specific regional mobility differences occurred only in cervical extension, whereas no consistent age-related differences were found. Stiffer individuals could be found in either gender or any age group, but rigidity in one plane did not necessarily predict rigidity in another.

Adult↗
PubMed1993

A randomized controlled trial of the efficacy, safety and cost of a single-use myocardial bioptome.

A randomized single-blind study was performed comparing a reusable 8 French bioptome with a single-use 7 French bioptome in a consecutive series of 63 myocardial biopsy procedures performed during follow-up of cardiac transplant patients. Safety, efficacy and cost were compared between 30 procedures performed with the single-use bioptome (Group I) and 33 procedures performed with the reusable bioptome (Group II). The two instruments were found equally efficient in obtaining adequate biopsy samples (69% of attempts for both instruments). The average specimen weight was not significantly different (Group I 2.5+/-1.3 mg, Group II 2.7+/-1.1 mg) despite different nominal jaw sizes. There was no significant difference in the incidence of incompletely cut specimens (Group I 13%, Group II 7%) and there were no complications in either group. The cost of the two instruments was, as expected, markedly different with an estimated average per-use cost of $250.00 for the single-use bioptome and $35.89 for the reusable instrument. In this small study, a single-use 7 French myocardial bioptome was found to be an acceptable substitute for the larger, reusable instrument with no decrement in specimen size. The substantial cost differential is noteworthy, although the maintenance required by the reusable instrument can present a formidable challenge.

Biopsy, Needle↗
PubMed1993

AASCIN strategic plan--1993-1998.

A long-standing commitment to planned growth and development are essential for the AASCIN to be effective in influencing the direction of spinal cord injury (SCI) nursing. Recognizing these needs, a long-range planning initiative was supported by the Board of Directors in March, 1990. A task force was charged with the responsibility for outlining the future of the AASCIN through the development of a five-year strategic plan. The long-range planning initiative was divided into two segments. First, a Delphi Study was developed to obtain membership input into AASCIN's priorities. Once this data was collected, the Strategic Planning Task Force synthesized the results of the study and developed a five-year AASCIN strategic plan. The purpose of this article is to describe the process and content of the proposed AASCIN strategic plan. The report begins with a brief description of the Delphi Survey, which forms the foundation for the strategic plan. Since the strategic plan needs to be congruent with the organization's mission statement and goals, the organizational plan of AASCIN is presented. Lastly, a brief summary of how the organization proposes to use this strategic planning document is provided.

Forecasting↗
PubMed1992

Anti-RNA polymerase I antibodies in the sera of MRL lupus mice at the initial stages of disease are directed primarily against phosphorylation-dependent epitopes.

Anti-RNA polymerase I (RPI) antibodies in the sera of MRL/Mp-lpr/lpr and MRL/Mp(-)+/+ mice, which develop an autoimmune disease similar to human systemic lupus erythematosus, were screened for reactivity with purified RPI or RPI which had been dephosphorylated. In every case (n = 10), dephosphorylation of RPI resulted in a significant decrease (33-95%) in antibody binding. The anti-RPI antibodies in the sera of the same mice approximately 6 weeks later also reacted better with untreated as compared to dephosphorylated RPI but, in every case, the decrease in antibody (0-30%) caused by dephosphorylation was substantially diminished. That the proportion of anti-RPI antibodies in the sera of MRL mice decreased with progression of lupus-like disease was confirmed by closely monitoring the antibodies over the course of disease. Anti-RPI antibodies produced at the earliest stages appeared to be directed almost exclusively against phosphorylation-dependent determinants since dephosphorylation of RPI essentially abolished antibody binding. Subsequently, the percentage of the total anti-RPI antibodies in the sera of these mice directed towards phosphorylation-independent epitopes increased linearly with time. The importance of phosphorylation-dependent epitopes on RPI for the development of the anti-RPI autoimmune response was supported by the observation that treatment of mice with alkaline phosphatase partially attenuated anti-RPI antibody production.

Animals↗
PubMed1991

Isolation and characterization of three endosomal fractions from the liver of normal rats after lipoprotein loading.

In earlier research we isolated and characterized three endosomal fractions from livers of estradiol-treated rats (1987. Belcher et al. Proc. Natl. Acad. Sci. USA. 84: 6785; 1989. Jäckle et al. Proc. Natl. Acad. Sci. USA. 86: 1880). We now describe the isolation of comparable endosomal fractions from untreated rats. The fraction of lowest density was composed almost exclusively of lipoprotein-filled multivesicular bodies (MVBs); the intermediate density fraction was composed of smaller lipoprotein-filled vesicles that were also multivesicular and had more numerous membranous appendages; the fraction of highest density was composed of membranes resembling the appendages of the two vesicular fractions. The paucity of contamination of these fractions with nonendosomal organelles is supported by their ultrastructural characteristics and by the proteins, lipids, and marker enzymes of their membranes. Only small amounts of MVBs could be separated from untreated rats not given a load of lipoproteins. However, after injection of large amounts of beta-very low density lipoproteins (beta-VLDL) from cholesterol-fed rabbits, the mass of MVBs increased dramatically. Under these conditions radiolabeled beta-VLDL and epidermal growth factor taken up by the liver accumulated in isolated endosomes at rates similar to those found for LDL in estradiol-treated rats. Although chylomicrons and chylomicron remnants were rapidly taken up by the liver of normal rats, chylomicrons and chylomicron remnants accumulated in endosomes at a lower rate than beta-VLDL. These findings, which differ from earlier data in estradiol-treated rats (1989 Jäckle et al., Proc. Natl. Acad. Sci. USA. 86: 1880) that showed equivalent rates of processing of chylomicron remnants and beta-VLDL, suggest that extracellular processing of chylomicron remnants in the liver normally ; precedes endocytosis.

Administration, Oral↗
PubMed1987

Relapsing Kawasaki's disease.

An 18-month-old child with Kawasaki syndrome twice developed severe recurrence of symptoms when the acetylsalicylic acid (Aspirin) dosage was decreased from 80 mg/kg/day. Care of the patient with Kawasaki disease should be directed toward control of symptoms as well as monitoring for cardiac involvement.

Aspirin↗
PubMed1984

Specific membrane receptors for atrial natriuretic factor in renal and vascular tissues.

Membranes from rabbit aorta and from rabbit and rat kidney cortex possess high-affinity (Kd = 10(-10) M) specific binding sites for atrial natriuretic factor (ANF). Similar high-affinity sites are present in an established cell line from pig kidney, LLC-PK1. Results of fractionation studies indicate that the receptors are localized in the plasma membrane of these tissues. The binding is time-dependent and saturable. An excellent quantitative correlation was found between the affinity of synthetic ANF and analogs of intermediate activity to aorta membranes and the half-maximal concentration needed for relaxation of rabbit aorta rings contracted by addition of serotonin. Furthermore, the binding affinity of the receptor in kidney membranes is consistent with the concentration required for in vivo natriuresis in the rat. Biologically inactive synthetic ANF fragments and other peptide hormones such as angiotensin II and vasopressin do not significantly inhibit binding. These data suggest that the receptors for ANF in vascular and renal tissues are responsible for mediating the physiological actions of this peptide in these target tissues.

Animals↗
PubMed1983

Speech perception and memory coding in relation to reading ability.

Previous work has demonstrated that children who are poor readers have short-term memory deficits in tasks in which the stimuli lend themselves to phonetic coding. The aim of the present study was to explore whether the poor readers' memory deficit may have its origin in perception with the encoding of the stimuli. Three experiments were conducted with third grade good and poor readers. As in earlier experiments, the poor readers were found to perform less well on recall of random word strings and to be less affected by the phonetic characteristics (rhyming or not rhyming) of the items (Experiment 1). In addition, the poor readers produced more errors of transposition (in the nonrhyming strings) than did the good readers, a further indication of the poor readers' problems with memory for order. The subjects were tested on two auditory perception tasks, one employing words (Experiment 2) and the other nonspeech environmental sounds (Experiment 3). Each was presented under two conditions: with a favorable signal-to-noise ratio and with masking. The poor readers made significantly more errors than the good readers when listening to speech in noise, but did not differ in perception of speech without noise or in perception of nonspeech environmental sounds, whether noise-masked or not. Together, the results of the perception studies suggest that poor readers have a perceptual difficulty that is specific to speech. It is suggested that the short-term memory deficits characteristic of poor readers may stem from material-specific problems of perceptual processing.

Auditory Perception↗
PubMed1979

Detrusor-sphincter dyssynergia.

We followed 62 patients with complete suprasacral spinal cord injuries and detrusor-sphincter dyssynergia for at least 2 years. The patients were evaluated urodynamically at regular intervals and 50 per cent were subjected to external sphincterotomy, after which they were compared for the presence of bacteriuria and upper urinary tract changes. Patients on prolonged intermittent catheterization did as well as those who achieved balanced bladder function as a result of sphincterotomy.

Adult↗
PubMed1969

[The night nurse].

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Nursing Care↗
PubMed1967

The night nurse.

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Nursing Service, Hospital↗