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Biomedical subjects

S Boucheron

Publications and source records attributed to S Boucheron.

At least 55 records · Page 3Linked to original sources
PubMed1987

[Adenoid cystic carcinoma or cylindroma of the cervix uteri. Review of the literature apropos of a personal case].

The authors report on a case of cylindroma of the cervix combined with a carcinoma in situ. Reviewing the literature which helped them, they studied the anatomo-pathological characteristics as well as the histogenesis and the therapy for cylindromas, which are more often found in other parts of the body. In particular, they are found in the salivary glands. There the origin is still uncertain and the evolution from the same stage is worse than in epidermoid carcinoma of the cervix.

Adult↗
PubMed1987

[Severe laryngeal dysplasia and synthetic retinoids].

Nine patients with "severe" laryngeal dysplasia as shown by multiple microbiopsies during laryngoscopy were treated with a synthetic derivative of retinol (Etretinate 0.5 to 1 mg/kg/day) over one or two months. Follow up histology after 8 to 18 months surveillance showed histologic improvement with respect to dyskeratosis, atypical cells and to a lesser extent epithelial hyperplasia. The use of synthetic vitamin A derivatives for "severe" laryngeal dysplasia is discussed.

Adult↗
PubMed1987

[Intratracheal destruction of tumor lesions: laser or cryotherapy? A preliminary analysis].

Intrabronchial laser has become the reference method for palliative destruction of intrabronchial tumours. Cryotherapy, which destroys tumours by cold-induced lesion at -89.5 degrees C, has recently been introduced. Over a 3-month period, 8 patients with malignant or benign proliferative stenosis of the main bronchi and trachea were treated by laser through a flexible Bronchoscope, under general anaesthesia. During the same period, 8 patients were treated by cryotherapy through a non-rigid probe passed into a bronchoscope, under general anaesthesia; 5 of these patients had malignant intrabronchial lesions and 3 had benign or low-malignancy lesions (hamartochondroma, cylindroma, benign carcinoid). Destruction by laser was relatively or absolutely contra-indicated in these 8 patients on account of total bronchial stenosis, prolonged infiltrating stenosis or previous failure of laser. Satisfactory bronchial recanalization was obtained by laser in 3 out of 8 patients, but this technique partially failed in 5 patients with prolonged or partially infiltrating stenosis; 2 of these 5 patients were successfully treated by cryotherapy. Among the 8 patients treated by cryotherapy, 6 were significantly improved, with total bronchial recanalization and destruction of the tumoral nodules. In 1 case tumoral destruction was too incomplete for re-ventilation, and in the last patient the multiplicity of lesions made objective assessment of the results impossible. No major side-effect ascribable to cryotherapy was observed. Cryotherapy performed through a non-rigid probe therefore seems to be as safe and effective method of bronchial recanalization. It is relatively inexpensive, mobile and painless, but its effects are delayed by 8 to 10 days.(ABSTRACT TRUNCATED AT 250 WORDS)

Aged↗
PubMed1986

[Intrapulmonary chemodectoma. A new case with ultrastructural study].

The authors report the case of a 40-year old woman who presented with a round tumour in the middle lobe of the right lung. Once removed, the tumour proved to be an intrapulmonary chemodectoma. Chemodectomas are tumours that are rarely present in the lung. Their pathogenesis is open to discussion. Their study by electron microscopy is interesting, as it shows grains of neurosecretion and provides additional information on the morphology of chemoreceptors.

Adult↗
PubMed1986

[Technics for the exploration of pulmonary arteriovenous shunts in liver cirrhosis. Apropos of 2 cases].

Pulmonary arterio-venous shunts represent a rare cause of hypoxia in cirrhosis. We present two cases, the first was an alcoholic cirrhotic with anthracosilicosis. This patient rapidly developed a picture of significant hypoxaemia with a raised alveolar-arterial oxygen gradient. The presence of this shunt was confirmed by a scintigraphic analysis. A porto-pulmonary localisation was excluded by a changing angiographic picture. Death supervened after refractory hypoxaemia. Post mortem microangiographic studies confirmed the pulmonary nature of the shunt and its pre-capillary localisation. The second patient was alcoholic, with a compensated cirrhosis and developed severe hypoxaemia which progressed to death in less than two months, when he was being treated effectively with corticosteroids for a diffuse interstitial pulmonary fibrosis confirmed histologically. The pulmonary localisation of the shunt was confirmed by an analysis of the angioscintigraphs. The different techniques for the investigation of intra-pulmonary shunt are discussed, as well as the patho-physiological mechanisms involved. The hormone levels measured (sex hormones, serotonin, prostaglandins, intestinal hormones) remained normal. The therapeutic trials tried out (oestrogen, CPD Choline, indomethacin) were ineffective.

Humans↗
PubMed1986

[Difficult diagnosis of a rapidly developing post-traumatic tumor of the thymus region. Encysted hematoma or intracystic hemorrhage?].

We report a case of rapidly developing (subacute) post-traumatic mediastinal haematoma which initially suggested a malignant tumour of the thymus region. The lesion, discovered on the basis of non-specific signal symptoms 2 months after a mild chest injury, consisted of a voluminous tumour of the thymus region associated with pericardial effusion. At angiography, the mass proved to be extravascular. CT scans of the thorax showed that it surrounded, but did not compress, the mediastinal vessels. Surgery revealed an organized encysted haematoma of the thymus region that had ruptured into the pericardial cavity containing a blood collection. The possibility of an intracystic haemorrhage in a cystic tumour preexisting to the trauma is discussed, but a more likely diagnosis would be chronic haematoma, especially since a similar case independent of any injury has already been published.

Adult↗
PubMed1984

[Carney's triad].

The triad described by J.A. Carney in 1977 is characterized by the successive or concomitant occurrence of three rare tumours of different origin: gastric leiomyoblastoma, functioning extra-adrenal paraganglioma and pulmonary chondroma. It is found mainly in young female patients with prevalent blood group A and may be incomplete, with only two of the three tumours occurring. The case of a young woman who developed gastric leiomyoblastoma and, six years later, pelvic paraganglioma is reported; she died of metastases from the paraganglioma with malignant hypertension. The 16 cases already published are reviewed. The authors insist upon the severity of paragangliomas and the need for a systematic search for the other tumours in patients who present with one tumour of the triad. A histogenetic interpretation relating the tumours to pathology of the neural crest is suggested.

Adult↗
PubMed1983

An autoradiographical topological study of the epithelial cell proliferative activity in the ascending colon of the mouse using a modified technique for determining the fraction of labelled mitoses (FLM).

In a previous study of the mouse ascending colon we showed that epithelial cell proliferation is more active on the tops of mucosal folds than in the flat mucosal areas between folds. In order to define the cytokinetic characteristics of this phenomenon more precisely, we have undertaken an autoradiographic investigation with 3H-thymidine. The fraction of labelled mitoses (FLM) curves and cell labelling indices have been worked out in fold top areas (FTA) and on flat areas off the folds (OFA). A new method has been adopted to draw the FLM curves. The results show no difference between the cell cycle times or in the times corresponding to G2-phase and S-phase in FTA and OFA. In contrast, the proliferative cell compartment in FTA is 40% higher than in OFA.

Animals↗
PubMed1983

Treatment of cutaneous lymphoma with etretinate.

Twelve patients with various types of lymphoma were treated with etretinate. The diagnosis included parapsoriasis en plaque, epidermotropic lymphoma (diffuse chronic erythroderma with atypical mononuclear cells, Sézary syndrome or MF tumours) and non-epidermotropic lymphoma. The patients received etretinate in a dose of 0.8 to 1.0 mg/kg/day for 2 to 14 months. No additional therapy was given. Patients with epidermotropic lymphomas stage I and II had a favourable clinical and histological response whereas those with deeply infiltrating tumours remained unresponsive. Patients with parapsoriasis en plaque and poikiloderma showed little response. Of the four patients who discontinued the treatment, three had recurrences after 3 to 4 months but one remained clear. The results obtained with etretinate may equal those obtained with more aggressive treatments.

Aged↗
PubMed1983

Melanocyte-lymphocyte interaction in human graft-versus-host disease.

Pigmentary disorders in chronic human GvHD comprise reticular or diffuse hyper- and hypopigmentation and seem to result from an interaction between lymphocytes and melanocytes. This interaction could be visualized by standard microscopy with a specific staining for melanin. The main ultrastructural findings were, in hyperpigmented areas: broad contact between melanocytes and lymphocytes, numerous and packed melanosomes, presence of cytoplasmic lipid droplets; in hypopigmented areas: disintegrating melanocytes with large intercellular spaces, small melanosomes, numerous lipid droplets, vacuolated organelles, as well as condensed and convoluted nuclei. Different hypotheses to explain the dysfunction of melanocytes are presented.

Adolescent↗
PubMed1983

[Intramedullary bronchogenic cyst. Apropos of 1 case. Discussion of the endo-ectodermal adhesion syndrome].

The authors report the case of a 40-year-old man who has presented for many years an intermittent progressive spastic paraplegia. Plain films of the spine show very important dysraphic abnormalities of the inferior dorsal column and the myelography shows a complete block suggesting an intramedullary space-occupying lesion at four levels above the vertebral abnormalities. The operation permits a total removal of an intramedullary "bronchogenic cyst". In the post-operative course, the neurologic deficit improves, six months later a spastic paraparesia remains. The review of the literature shows that this is an exceptional observation. Intramedullary bronchogenic cysts must be regarded as similar to intramedullary enterogenic cysts. They are not teratomas but dysembryoplasiae due to failure of the ento-ectoblastic separation between the second and the third weeks of life. These cysts form a part of the "ento-ectodermal adhesion syndrome" of Prob et al. The preoperative diagnosis is possible on the association of intermittent progressive syndrome of medullary compression and dysraphic spondylotic changes. The total surgical removal of the cyst, by micro-surgical techniques, is able to preserve the neurologic evolution with an excellent result if the operation is performed before definitive neurologic deficits occur.

Adult↗
PubMed1982

[Colonic localization of pseudopolypoid type disclosing Recklinghausen's neurofibromatosis].

A case of colonic Recklinghausen neurofibromatosis found in a forty-two-year-old woman is presented. Only the colon was affected. The first symptom was rectal bleeding. Widespread polypoid lesions involving the rectum, sigmoid, left colon and part of the transverse colon were demonstrated upon barium enema and rectosigmoidoscopic examinations. As demonstrated by a review of the medical literature, colonic involvement in Recklinghausen disease is very infrequent and forms restricted to the colon are exceptional. The pathologic findings and the clinical, radiological and endoscopic features in colonic neurofibromatosis are described. It seems that total colectomy should be advocated. Our patient underwent total colectomy ten years ago and has experienced neither recurrence nor other manifestations of Recklinghausen disease.

Adult↗
PubMed1982

A topological study of the epithelial cell proliferation in the ascending colon of the mouse.

Epithelial cell proliferation has been studied from a topological point of view, in the ascending colon of the mouse. The ascending colon was investigated because it offered the possibility of studying distinct mucosal sites according to whether they are situated on folds or away from the folds. Consequently fold top areas (FTA), fold side areas (FSA), flat mucosa areas (OFA) have been studied individually. To determine mitotic activity, we have used the technique of arrested metaphases by a stathmokinetic agent. The estimate of the epithelial compartment size has been undertaken according to a stereological methodology. The topographical study consisted of three parts: a reproduction of the mitotic density distribution on a colonic area of significant importance; a topographical stathmokinetic study; a reconstitution of the profile of mitotic densities all along a mean model mucosal fold. The findings obtained from these different approaches present evidence that the distribution of mitotic activity within the colon is not homogeneous, that the relief of the mucosa is a factor occurring in proliferative cellular activity. The highest mitotic densities are situated on FTA, and the lowest ones on OFA. Mitotic density increases on the fold, in the terminal fifth of its length.

Animals↗