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Biomedical subjects

S Boucheron

Publications and source records attributed to S Boucheron.

At least 37 records · Page 2Linked to original sources
PubMed1994

Factor XIIIa expression in juvenile xanthogranuloma.

Dermal dendrocytes constitute the largest population among cells of dermatofibromas. In other histiocytic tumours, the exact nature of histiocytic cells is not known. We have searched for the presence of dermal dendrocytes in juvenile xanthogranulomas. The immunohistochemical study was performed on 9 juvenile xanthogranulomas. We used monoclonal or polyclonal antibodies: anti-XIIIa, HAM56, anti-S100, anti-NSE, anti-HLA-DR, anti-CD68 and anti-lysozyme. Phagocytic mononuclear cells (histiocytes, giant cells, Touton cells) did not express Langerhans' cell markers (S100, NSE ou HLA-DR). They weakly expressed markers of macrophages (CD68, lysozyme). There was a very strong binding by HAM56 and anti-XIIIa. This expression was more evident on xanthomatous and newly appeared tumours than on fibrous tumours. The largest population of juvenile xanthogranuloma cells appeared to be constituted by dermal dendrocytes. These cells are perhaps the key-cells of a continuum of benign tumours, from juvenile xanthogranuloma to dermatofibroma, with different stages corresponding to different proportions of dendrocytes, lymphocytes and fibroblasts.

Adolescent↗
PubMed1994

[Iris tuberculosis. A propos of a case diagnosed by iridectomy].

Ocular tuberculosis is currently rare in developed countries. We report a case of tuberculous nodular anterior uveitis which revealed primary tuberculosis in a 2-year old girl. This diagnosis was established on microscopic examination of a surgical iridectomy specimen. Thus, a metastatic retinoblastoma was eliminated. The subsequent clinical investigations showed that the girl's father had active pulmonary tuberculosis.

Child, Preschool↗
PubMed1993

Multiple juvenile xanthogranulomas without foam cells and giant cells.

A 4-month-old boy had numerous nodular lesions. Microscopic findings revealed a histiocytic proliferation without foam cells and giant cells. Immunohistochemical studies showed that the histiocytes belonged to the monocyte-macrophage system and not to the Langerhans cell system. This case is an unusual variant of juvenile xanthogranuloma that, when congenital, may be difficult to differentiate from Hashimoto-Pritzker disease.

Histiocytes↗
PubMed1992

Serpentine supravenous hyperpigmentation induced by the nitrosourea fotemustine.

Two cases of serpentine supravenous hyperpigmentation developing in the area of fotemustine infusions are reported. Histological features showed an increased melanin synthesis and the presence of melanophages without focal degeneration of basal cells or dermal inflammatory infiltrate. Perls' strain was negative. Hypotheses concerning the mechanisms of increased melanin synthesis over the veins are discussed.

Adult↗
PubMed1992

[Multifocal tuberculosis with cerebellar tuberculoma].

A 10-year old child was admitted for vomiting and a high grade fever. He had been previously immunized twice against tuberculosis. A cerebellar syndrome appeared, and the brain CT scan showed an intracerebellar mass. Disseminated lesions were detected on abdominal (splenic abscess) and thoracic (mediastinal lymph nodes) CT scans. The bone scintigraphy also showed multiple localisations. A craniotomy was performed that revealed a cerebellar tuberculoma which was completely removed. The child received an antituberculous treatment over 18 months and is currently well with a 5 year follow-up.

Antitubercular Agents↗
PubMed1991

Pathology of roots, spinal cord and brainstem in syringomyelia-like syndrome of Tangier disease.

We report here a post-mortem examination of a 46-year-old patient who died after a 23-year-long syringomyelia-like syndrome of Tangier disease. The L5 dorsal root and the superficial peroneal nerve showed fiber loss and lipid vacuole accumulation in Schwann cell cytoplasm. The L5 ventral root had moderate fiber loss without lipid vacuoles. In the cervical roots, fiber loss was intense and there were no foamy Schwann cells. Motor neuron loss was severe in the cervical spinal cord and the facial nerve nucleus and slight at the lumbar level. Under electron microscopy, some neurons of the lower spinal cord showed atypical inclusions. These data suggest that an unknown metabolic defect is responsible for a primary neuronopathy. Lipid accumulation in Schwann cells, resulting from fiber degeneration is probably transient, accounting for the absence of foamy cells in regions with longstanding involvement.

Autopsy↗
PubMed1991

[Two benign vascular tumors of the kidney capsule].

Capsular tumors of the kidney are uncommon or poorly documented. The authors report two cases of benign vascular tumors: a so-called "vascular leiomyoblastoma" and a glomus tumor. An ultrastructural study of the first tumor demonstrated smooth muscular characteristics. Obvious histological features of glomus were seen in the second. Immunohistochemical study revealed positive immunoreactivity for epithelial and mesenchymal antibodies in the two tumors. Glomus tumor originates from the particular system of vessels in the capsule. Histogenesis of the vascular leiomyoblastoma is more controversial. This tumor could be akin to leiomyomas of the renal capsule and intra parenchymatous leiomyomas; lymphatic origin and even a glomangiomatous nature are also possible explanations.

Aged↗
PubMed1991

Epidermal and urethroid penile cyst.

The authors describe a 74-year-old man who presented with a 2-cm nodule on the ventral face of the penis, showing histologically a cyst lined by both epidermal and urethroid epithelium. The authors discuss the various histological forms of raphe median cysts of the penis.

Aged↗
PubMed1990

A quantitative study of epithelial alterations during the early stages of experimental colonic tumorigenesis in mice.

The weekly administration of 1,2-dimethyl-hydrazine (DMH) by subcutaneous injection for a period of 16-20 weeks is a well known procedure for producing colonic tumors in mice and rats. Quantitative histomorphological, histochemical and kinetic studies, as well as investigation of the significance of epithelial cell density were carried out in mice between the 7th and the 91st day after the first DMH injection. These studies showed that between the 28th and the 35th day, several simultaneous alterations in the colonic epithelium involving modification of glandular form, decreased mucus secretion, an increase in epithelial cell density and an increase in the number of S phase cells (BrdU labeling index: LI). Around the 35th day, the glands tended to expand and from the 35th to the 63rd day, they were stretched and displayed compartments of dedifferentiated and non-mucinous crypts (DNMC). In these crypts the cell density became very high, reaching twice the control value on the 91st day. This feature was accompanied by alteration in cell morphology and by an increase in the available basement membrane area. A decrease in mucus secretion was apparent from the 14th day and by the 63rd day, mucus secretion was only about 60% of the control value in all crypts. The LI was increased until the 35th day following which a paradoxical and progressive decrease occurred in all glandular compartments.

1,2-Dimethylhydrazine↗
PubMed1990

[Primary adenocarcinoma of the ileostomy after total proctocolectomy for ulcerative colitis].

A 61-year-old man developed primary adenocarcinoma with skin invasion, at the ileostomy site 33 years after a proctocolectomy for ulcerative colitis. A total of eleven patients with ileostomy adenocarcinoma have been reported in the literature. Ten patients were treated surgically for ulcerative colitis and the other for adenomatous polyposis coli. The diagnosis of stomal malignancy was made 9 to 36 years after the ileostomy (mean interval, 22 years). The pathogenesis of the malignant growth is uncertain and several possibilities are discussed: stasis, severe chronic inflammation, colonic metaplasia and severe dysplasia of the ileal mucosa. When an ileostomy requires late revision for inflammatory changes, careful pathologic examination of the entire stoma and surrounding skin is essential.

Adenocarcinoma↗