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Biomedical subjects

S Bengmark

Publications and source records attributed to S Bengmark.

At least 271 records · Page 15Linked to original sources
PubMed1980

Increased bleeding during liver resection in ethanol-intoxicated rats.

The effect of ethanol intoxication on hemostasis after liver resection was studied in the rat. Plasma levels of ethanol were within the range of those found in ethanol intoxication in man. Bleeding time and blood loss were significantly increased, whereas hemoglobin and hematocrit values were decreased after resection in intoxicated animals compared to controls. APT-times and platelet counts did not differ significantly between the two groups of rats. ADP- and collagen-induced platelet aggregation was slightly inhibited one hour after ethanol administration in non-operated animals. A decrease in pH, such as observed in intoxicated animals, did not affect hemostasis. Distribution of cardiac output was significantly altered ethanol intoxication. Renal blood flow was increased by 54%, blood flow in the hepatic artery by 40% and in the portal vein by 47%.

Acidosis↗
PubMed1980

Retroperitoneal sarcoma treated by surgery.

A retrospective analysis of extensive surgery with resection of retroperitoneal sarcoma and total or partial resection of adjacent organs in 15 patients is presented. Dominating symptoms were a palpable mass (80%). The tumor was felt in all patients. In 9 of 10 patients, ultrasonography showed a solid tumor with retroperitoneal location. In 14 patients (93%) the tumor was removed, in 11 of them adjacent organs also. Five of the patients were subjected to more than one operation because of tumor recurrence. Two patients died postoperatively. Six patients are alive without tumor recurrence; and three, with recurrence 18 to 62 months after the first operation. Four patients died 5--24 months after primary operation. In seven patients (50%), the tumor recurred locally. Surgery for recurrent tumor was beneficial. Complete surgical removal provides the most effective therapeutic approach. Routine second-look operation within a year after primary surgery may be a way to improve the results. Adjuvant cytostatic therapy could be considered.

Adult↗
PubMed1980

Evaluation of aggressive surgery for carcinoma of the extrahepatic bile ducts.

The records of 80 consecutive patients with extrahepatic bile duct cancer, 45 women and 35 men, median age 70 years (33-89 years), were reviewed. The histologic diagnoses were adenocarcinoma in 45 patients, 34 cholangiocarcinoma and one squamous cell carcinoma. In 34 patients the tumor was located to the confluence, the right or left hepatic duct, in 16 to the middle and in four to the distal portion of the bile duct. In the remaining 26 patients the tumor comprised more than one of these locations (mixed location). Twenty-seven of the 80 patients (34%) were operated on with resection of the tumor. Among patients 70 years of age and younger the resectability rate was 57%. In nine patients the main surgical procedure was bile duct resection, in 15 patients bile duct resection and liver lobe resection, in 2 patients total pancreatectomy and in one local excision were performed. The resection of the tumor was regarded as radical in 12 patients and palliative in 15. The mortality rate was 11% after resection as compared to 30% in patients with nonresectable tumors. The most common postoperative complication was insufficiency of the anastomosis which occurred in seven patients. Three of these patients required reoperation. The median survival time in patients operated on with radical resection was 20 months, palliative resection 7(1/2) months and in patients with nonresectable tumors 2(1/2) months. The quality of life was estimated according to a special schedule and was found to be improved after resection as compared to nonresection. Patients operated with radical resection spent significantly less of their remaining life at hospital as compared to palliatively resected patients or patients with nonresectable tumors.

Adenocarcinoma↗
PubMed1980

Trauma an acetylsalicylic acid-induced changes in hemostasis during liver resection in the rat.

The effect of acetylsalicylic acid and bilateral femoral crush fractures on hemostasis after liver resection was studied in the rat. Serum salicylate levels were dose-dependent and similar in traumatized and non-traumatized animals. Bleeding time was significantly shortened and blood loss significantly decreased after bilateral femoral crush fractures. Both these values were significantly increased in salicylate pretreated animals compared to controls. Combination of bilateral femoral crush fractures and administration of 0.7 mg/100 g b.w. acetylsalicylic acid after bilateral femoral crush fractures increased blood loss significantly. Normal APT times indicated that the intrinsic coagulation system was not affected. ADP- and collagen-induced platelet aggregation was diminished in all animals as compared to controls.

Animals↗
PubMed1980

Circulating microaggregates after gastric administration of ethanol in the pig.

Earlier in vitro experiments have shown microaggregate formation in pig and rabbit blood after addition of ethanol. In this study ethanol was given to pigs resulting in ethanol concentrations of 30-40 mmol/l 2-4 h after administration. As would be expected ethanol concentration was higher in the portal vein than in the hepatic vein, caval vein or aorta. Microaggregates in circulating blood were measured with screen filtration pressure (SFP). SFP rose to more than double the initial value in ethanol-intoxicated pigs whereas it remained unchanged in controls. The ethanol-intoxicated pigs developed hemoconcentration and metabolic acidosis. Our results indicate that microaggregates probably made up of aggregated platelets are formed in pig blood during acute ethanol intoxication.

Acidosis↗
PubMed1979

New pathways in portal hypertension surgery.

An individualized treatment of portal hypertension is advocated. The treatment is suggested to be based upon the presence of complications to the disease: bleeding oesophageal varices, insufficient cardia function, regurgitation and oesophagitis, hyperacidity, stomach and duodenal ulcer, ascites and hypersplenism. The choice of method of treatment of the patient depends on the presence of the symptoms. There are several methods available. These can be divided in methods directed against one symptom - unisymptomatic treatment - and methods directed against several symptoms - polysymptomatic treatments. The author advocates a more frequent use of decongestion operations and pexi operations. For acute control of bleeding varices it seems that sclerotherapy is the preferred choice at present.

Brain Diseases↗
PubMed1979

Subcutaneous transposition of the spleen: a method for treatment of complications in portal hypertension?

Eleven patients with portal hypertension were treated with subcutaneous transposition of a resected spleen. In eight of the patients the operation was performed after variceal bleeding. In this group there was one operative mortality--a 77-year-old woman. Another patient died after 28 months in upper gastrointestinal bleeding. Autopsy showed varices in the gastric fundus and a cancer in the cardia. The other six patients are alive and in good health after 41--60 months. The operation was performed in another three patients, who had not bled. The indication was hypersplenism and esophageal varices in two and severe thrombocytopenia in one. Two of these patients (both with advanced hepatic disease) died postoperatively. The operation is proposed as an alternative method in the treatment of portal hypertension--especially when the main problem is hypersplenism. The operation has no negative effects on liver function and does not cause encephalopathy. Hypersplenism is cured. The survival time and freedom from postoperative bleeding among those who bled preoperatively is in the present material very satisfactory. However, the operation cannot be recommended for the prophylactic treatment of patients with esophageal varices who have not bled--at least not in the patient with advanced hepatid dysfunction.

Adolescent↗
PubMed1979

Obliteration of esophageal varices by PTP: a follow-up of 43 patients.

The percutaneous transhepatic portal vein catheterization (PTP) with selective obliteration of the coronary vein and/or the short gastric veins in treating bleeding esophageal varices was introduced in 1974. In order to prevent recanalization of the vessels Bucrylate (isobutyl-2-cyano-acrylate) has been used in 43 patients 55 times during a period of 34 months (October 1975 to July 1978). The obliterative treatment was followed by rebleeding in 35% of the cases and continued bleeding occurred in two patients. Fourteen patients were treated on 16 occasions during acute bleedings, and five of these (36%) died within two months from a portal vein thrombosis caused by the obliterative procedure. Because of these findings PTP with obliteration of the veins feeding the esophageal varices is not recommended as an elective way of treatment. It should only be used in the acute bleeding patient when transesophageal sclerosering therapy, continuous vasopressin infusion and balloon tamponade have failed. Fifty-six per cent of the patients acutely treated stopped bleeding for more than one week, thus avoiding an emergency shunt or devascularization operation which are associated with a high mortality rate.

Adolescent↗
PubMed1979

Hepatic necrosis in the pig produced by transient arterial occlusion.

The effects of transient liver ischaemia were studied in young pigs. At operation, a specially designed ligature sling was placed around the hepatic artery and brought out through the abdominal wall so that it could be later tightened. All other routes of arterial supply to the liver were divided. The arterial supply was occluded for 1, 2, 4 or 12 h on the 1st and 3rd postoperative days. Ischaemic damage was assessed histologically and by serum ASAT and acid hydrolase levels. Liver necrosis developed after 1--2 h of occlusion and increased after 4 and 12 h of occlusion. Ischaemic liver damage was reduced when the operation and occlusion were separated by 72 hr.

Animals↗
PubMed1979

Changes in the costs of elective cholecystectomies, 1955-1965-1975.

The costs for elective cholecystectomies were measured 1955, 1965 and 1975. The average length of stay decreased by 25% between 1955 and 1965 and with the same amount between 1965 and 1975. In spite of these marked reductions in the average length of stay there was only a significant decrease in costs between 1955 and 1965 but not between 1965 and 1975.

Cholecystectomy↗
PubMed1978

Isobutyl 2-cyanoacrylate (bucrylate) in obliteration of gastric coronary vein and esophageal varices.

Percutaneous transhepatic portography was performed in 22 patients with liver cirrhosis and portal hypertension. All patients had bled or were bleeding from presumed esophageal varices. One or more veins feeding esophageal varices were occluded with bucrylate. Follow-up examination in eight patients 1-12 months later showed recanalization of previously obliterated veins in six; however, these veins were markedly smaller than before the procedure. In patients where veins were still occluded, new veins had opened up and carried blood to the esophageal varices, which were filled to a lesser degree than before. In our experience, bucrylate is superior to Gelfoam, thrombin, and Etolein in producing venous occlusion.

Adult↗