Search PubMed⌕ Search

Biomedical subjects

S Bengmark

Publications and source records attributed to S Bengmark.

At least 253 records · Page 14Linked to original sources
PubMed1983

The role of auscultation and registration of bowel sounds in the diagnosis of acute appendicitis.

The study described was designed to evaluate the role of auscultation and registration of bowel sounds in the diagnosis of acute appendicitis. In 37 patients with suspected acute appendicitis undergoing appendicectomy the bowel sounds were registered twice pre-operatively and once on the postoperative day. The results show that single registration of bowel sounds is rarely diagnostic, but repeated examinations with the method used in this study might provide an additional factor to reaching a diagnosis. However, the results are difficult to apply directly to the clinical situation, and further evaluation of this method, as well as an improvement of the technical equipment used, is essential.

Acute Disease↗
PubMed1982

Evaluation of splenic embolization in patients with portal hypertension and hypersplenism.

Twenty-five patients with hypersplenism caused by portal hypertension were treated by repeated partial splenic embolization. Fourteen surviving patients were followed for up to six years showing a good response on peripheral blood count and bleeding tendency. Three patients died in connection with the treatment and another eight died within half a year because of the underlying liver disease. The discomfort and complications of fever, pain, pleural effusion, and abscess formation and the possibility to avoid these by repeated partial embolization under antibiotic cover are discussed. The results are compared with reports in the reviewed actual literature and the splenic embolization is given a place among the means of a successful selective symptomatic treatment of partial hypertension.

Adult↗
PubMed1982

Effect of acute ethanol intoxication on primary haemostasis, coagulation factors and fibrinolytic activity.

The effect of ethanol intoxication on haemostasis was studied by transection of mesenteric microvessels and liver resection in the rat. Plasma concentrations of alcohol were within the range of those found in ethanol intoxication in man. Bleeding time and blood loss were increased 1 h after ethanol administration, regardless of the utilized technique. A significant positive correlation existed between bleeding time following liver resection and bleeding time after simultaneous transection of a mesenteric arteriole and venule. Coagulation mechanisms, assayed by whole blood clotting time, APT time, one-stage prothrombin time, recalcification time, thrombin time, Owren's P & P test and determination of plasma factor V and fibrinogen levels, were not significantly changed in ethanol-intoxicated animals. Administration of alcohol did not affect fibrinolytic activity, while it inhibited significantly ADP and collagen-induced platelet aggregation in the rat.

Alcoholic Intoxication↗
PubMed1982

Emergency and long-term transesophageal sclerotherapy of bleeding esophageal varices. A prospective study of 50 consecutive cases.

Fifty consecutive unselected patients with endoscopically proven bleeding esophageal varices were on 76 occasions during 3 years treated with transesophageal sclerotherapy. One-week hemostasis was obtained in 89%, with a hospital mortality of 14%. Three major complications (1.1%) occurred, with one fatal outcome. Long-term repeated sclerotherapy was instituted according to our protocol in all the survivors. During a mean follow-up period of 26 months 19 patients have been treated with sclerotherapy alone, 10 had elective and 2 had emergency operative procedures because of rebleeding. Six fatal bleedings occurred, four after sclerotherapy alone. The 3-year survival is calculated to be 49%. Sclerotherapy has proven to be effective and safe and can be recommended especially in the acute situation. It can also be used as long-term treatment, but rebleedings will in several cases necessitate operative procedures.

Adult↗
PubMed1982

[New principles in liver surgery].

39 patients with metastases to the liver from colorectal cancer were treated with liver resection. The average survival time was 25 months. 11 patients are alive after 10 to 102 months. 18 patients had liver resection for primary liver cancer. The average survival time was 27 months. 4 patients are alive after 27 to 84 months. 16 patients had temporary dearterialisation for carcinoid. All the surviving patients were free from symptoms for at least 6 months.

Aged↗
PubMed1982

Peritoneovenous shunting for intractable ascites.

For 5 years (1976-1981) peritoneovenous shunting has been used in 32 patients with intractable ascites--that is, in patients in whom medical therapy has failed. All operations but one were performed using local anesthesia. The LeVeen shunt was used in 29 patients and the Denver shunt in three patients. Good palliation was achieved in 14 of 23 patients with ascites due to liver cirrhosis. Seven out of eight patients with tense ascites secondary to malignancy were relieved. Complications were seen in six patients. In one patient severe disseminated intravascular coagulopathy made removal of the shunt necessary. Leakage, local infection, and skin necrosis, when present, could successfully be treated without removing the shunt. The surgical procedure is simple and offers relief to most patients with tense ascites resistant to medical therapy.

Adolescent↗
PubMed1981

In vitro effect of ethanol on ADP and collagen-induced platelet aggregation.

Platelet aggregation was measured by Born's method. Plasma from Sprague-Dawley rats and inbred albino rabbits was used. 20% ethanol in 0.9% (w/v) NaCl was added to plasma at final concentrations of 56.5 mM, 85.9 mM 171.5 mM and 343.1 mM or to whole blood at final concentrations of 8.7 mM, 17.4 mM, 52.5 mM, 171.5 mM and 343.1 mM. Experiments using 0.9% NaCl volumes equivalent to the added ethanol volume were also conducted. Dose-response aggregation tests showed that a decrease in ADP- and collagen-induced aggregation existed when ethanol was mixed with rat or rabbit blood prior to the preparation of platelet-rich plasma. There was no effect on ADP-induced platelet aggregation when ethanol was mixed with rat or rabbit plasma. Collagen-induced aggregation was impaired only in rat plasma when ethanol concentration reached 343.1 mM. These results suggested that ethanol modified platelet function possibly via red cells.

Adenosine Diphosphate↗
PubMed1981

Transient hepatic dearterialization followed by regional intra-arterial 5-fluorouracil infusion as treatment for liver tumors.

Twenty consecutive patients with secondary liver tumors were treated with a new method of liver dearterialization, performed by transient occlusion of the hepatic artery with strangulating slings, and followed by regional intra-arterial infusion of 5-fluorouracil. Tumor regression was confirmed by angiography, laboratory tests and symptom relief in more than 50% of the patients. For patients with metastatic colorectal carcinoma the mean survival time after operation was 17 months and the median survival time was 11 months. The most common complications were abscesses and aneurysms. The treatment is judged suitable for patients with a tumor of moderate severity involving both liver lobes and without extrahepatic tumor growth.

Adult↗
PubMed1981

Defects in hemostasis produced by antibiotics. An in vivo study in the rat.

The effect of preoperative infusion of benzylpenicillin, carbenicillin, ampicillin, chloramphenicol and doxycycline on hemostasis after standardized liver resection was studied in the rat. Plasma levels of each antibiotic were within the range of those found after administration of therapeutic doses in man. Bleeding time was prolonged and blood loss was increased in all cases of antibiotic administration compared with controls. APT time after liver resection was prolonged in the carbenicillin- and chloramphenicol-treated groups. Platelet function, assayed by ADP- and collagen-induced platelet aggregation was impaired in benzylpenicillin-, carbenicillin- and chloramphenicol-treated animals.

Ampicillin↗
PubMed1981

Improvement of the splenectomized rat model for overwhelming pneumococcal infection. Standardization of the bacterial inocula.

Studies conducted on rats have shown an increased susceptibility after splenectomy to intravenously introduced pneumococci. One of the main obstacles in such experiments, as regards reproducibility, is the maintenance and handling of the bacteria. A procedure is described for the preparation of standardized inocula and preservation of the bacteria at -80 degree C. No change in viability or virulence was observed after storage for at least 6 months. A pronounced difference in susceptibility to type 1 pneumococci was found between sham-operated (LD100 greater than 2 X 10(4) colony-forming units) and splenectomized rats (LD100 less than 2 X 10(2) colony-forming units); in the latter group, the survival time was inversely correlated to the quantity of bacteria injected.

Animals↗
PubMed1981

[Organization of diagnosis, treatment, and further measures for patients with gastrointestinal cancer (author's transl)].

One third of the total surgical care at the Department of Surgery, University of Lund, Sweden, is for cancer patients. Gastrointestinal cancer occupies 9,000 of a total of 12,000 bed-days and this disease is usually handled by the team who cares for the specific organ in which the cancer is localized. A particularly important part of gastrointestinal care is endoscopy (gastroscopy and colo-sigmoideo-rectoscopy). These diagnostic procedures can sometimes be curative. The value of preoperative liver tests for diagnosing liver metastases in colorectal cancer is very low because of the low prevalence of liver metastases in this population. Palliative therapeutical procedures, such as Celestin-tubes for esophageal or cardia carcinoma and transhepatic endoprostheses for bile duct occlusive cancer, have been tested. Palliative cytostatic therapy is partly established, i.e., intraarterial infusion of 5-FU for recurrent rectal carcinoma in the lower pelvis. This type of treatment has a very good pain relief effect. Cytostatic therapy for tumour control in patients without symptoms e.g. primary or secondary liver carcinomas, has not yet been established. Most of the patients with cytostatic therapy are treated on an outpatient basis. The cytostatic therapist must always be properly protected when working with cytostatic drugs. It is very important that the patient who gets cytostatic therapy is followed in order to see if the drug has any growth-controlling effect. A cost-benefit analysis of the therapy should also be made.

Antineoplastic Agents↗
PubMed1981

[Background and experience of adjuvant cytostatic therapy in gastrointestinal cancer (author's transl)].

Survival rates for patients with colorectal cancer have remained unchanged during the last 30 years. Every third patient with colon cancer Dukes' C and every fourth patient with rectal cancer Dukes' C survives 5 years. Of the patients who succumb to colorectal cancer, 85% will die within 3 years from diagnosis. There are many studies concerning the mechanisms of adjuvant chemotherapy. Its effectiveness has been proven in animal experiments. Micrometastases have a large growth fraction, few non-proliferative cells, and because of this, increased sensibility to cytostatics. Adjuvant chemotherapy aimed at treating occult metastases. In colorectal cancer the combination of 5-FU and Nitrosurea has been shown to have a better effect than 5-FU alone. Grage et al. have shown patients with colorectal cancer Dukes' C to have a longer tumour-free interval with adjuvant 5-FU, and this treatment gives patients with rectal cancer a prolonged survival time. In an adjuvant study, peroral 5-FU 90 days versus placebo did not show any effect. In another adjuvant study Vincristin, CCNU and 5-FU treated patients had fewer tumour recurrences than control patients. The observation time is, however, rather short. Adjuvant chemotherapy for colorectal cancer has shown promising results and it is hoped that further attempts with other forms of cancer in the gastrointestinal tract will also yield the same results.

Antineoplastic Agents↗