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Biomedical subjects

S Bank

Publications and source records attributed to S Bank.

At least 109 records · Page 6Linked to original sources
PubMed1979

Bicitropeptide, antacid and placebo in gastric and duodenal ulceration. A two-centre, double-blind, comparative endoscopic study.

A bismuth-peptide complex (BCP Compound), an antacid (Maalox) and corresponding placebos were studied in a 6-week comparative double-blind trial of treatment in 106 randomized ambulant patients with endoscopically proven duodenal and gastric ulcers. Patients were examined after 1, 3 and 6 weeks' treatment and results assessed separately for duodenal and gastric ulcers on endoscopic evidence at weeks 3 and 6 respectively. Bicitropeptide was significantly better than antacid and placebo at 3 and 6 weeks for treatment of both duodenal and gastric ulcers. In the bicitropeptide group 100% of the patients in the duodenal ulcer group and 95,2% in the gastric ulcer group responded to treatment (improved or healed). No haematological or biochemical changes were noted and no adverse effects were recorded.

Adult↗
PubMed1979

Insulin secretion and pancreatic exocrine function in patients with chronic pancreatitis.

The relationship between insulin responses to oral glucose and pancreatic exocrine function were examined in 15 patients with chronic pancreatitis. Good correlations were found between the insulin responses and exocrine pancreatic function measured as the concentrations of pancreatic enzymes in duodenal juice after intravenous cholecystokinin-pancreazymin (CCK-PZ). There appears to be a roughly parallel loss of endocrine and exocrine function in the course of chronic pancreatitis.

Administration, Oral↗
PubMed1979

Meat bolus impaction of the lower esophagus associated with a paraesophageal hernia. Successful noninvasive treatment with intravenous glucagon.

Ferrucci and Long recently reported the relief of esophageal food impaction with the use of intravenous glucagon in three patients. Our first experience in using this new procedure was very successful and gratifying. The essence and purpose of this brief communication is to record and further substantiate the efficacy of a new treatment modality.

Esophagogastric Junction↗
PubMed1979

Bismuth toxicity in man - I. Bismuth blood and urine levels in patients after administration of a bismuth protein complex (Bicitropeptide).

In the course of a double-blind clinical trial of treatment involving a bismuth protein complex (Bicitropeptide), an antacid and placebo, blood samples (33 patients) and urine samples (43 patients) were collected for bismuth analysis from patients on bismuth therapy at the beginning of the trial (week 0) and at weeks 3 and 6. Base line blood (2 - 11 ng/l) and urine (2 - 29 ng/l) values were not zero and appeared to have reached "saturation" values in many cases after 3 weeks (Blood : 4 - 33 ng/l and Urine 60 - 600 ng/l). After 6 weeks, blood values were 5 - 20 ng/l and urine values 63 - 780 ng/l. It is concluded that these blood and urine levels are not associated with significant toxicity in man.

Antacids↗
PubMed1978

The Mallory-Weiss syndrome. A prospective study in 130 patients.

The clinical features of the Mallory-Weiss syndrome were prospectively documented in 130 of 1 667 patients submitted to endoscopy for gastro-intestinal haemorrhage, an incidence of 7,8%. The important clinical features found in these patients were: alcohol abuse (21%); retching or vomiting (38%); salicylate ingestion (36%); dyspepsia (39%). The correct clinical diagnosis was therefore often difficult to make. Additional lesions were found in 40% of patients at endoscopy. Blood loss was relatively small, and surgery was not required in any patient. The 2 deaths that occurred were not attributable to haemorrhage. A high index of suspicion and early endoscopy are required to establish the diagnosis.

Adolescent↗
PubMed1978

The effect of calcitonin on secretin-stimulated pancreatic secretion in man.

The effect of calcitonin on pancreatic secretion was studied in man. After steady-state secretion had been achieved with a constant intravenous infusion of secretin (2 microgram/kg/h), either calcitonin (0,16 and 0,32 microgram/kg/h) or 0,15M NaCl was infused over a period of 80 minutes. Calcitonin did not affect pancreatic volume output or bicarbonate concentration, but amylase concentration and output were significantly inhibited (P less than 0.025). The colour index in the duodenal juice was unchanged by calcitonin. No changes were observed in blood glucose or serum calcium concentrations.

Adult↗
PubMed1978

Sweat electrolytes in chronic pancreatitis.

Sweat electrolytes were carried out in 84 adult patients with calcific pancreatitis, 51 with noncalcific pancreatitis, and the results compared to 37 adult controls. Of the patients with calcific pancreatitis, 33.5% had sweat sodium levels greater than 90 mEq/liter and 14.4% a level greater that 120 mEq/liter. Patients with noncalcific pancreatitis also had a high incidence of elevated sweat sodium levels. Sweat potassium levels were less discriminating, and there appeared to be high sweat calcium levels in a few patients so tested. The reasons for the elevated sweat sodium levels in pancreatitis is not readily apparent, and the possible relationship to heterozygous forms of cystic fibrosis is discussed.

Adolescent↗
PubMed1978

Jejunal monosaccharide, water, and electrolyte transport in patients with chronic pancreatitis.

Jejunal perfusion studies were performed to assess water, electrolyte, d-xylose, and d-glucose transport in 16 patients with chronic calcific pancreatitis (eight with and eight without steatorrhoea) and in 10 control subjects. The patients with steatorrhoea demonstrated significantly less xylose, water, and electrolyte absorption than patients without steatorrhoea and control subjects, when an isosmotic slaine-xylose solution was perfused. On the other hand, when an isosmotic saline-glucose solution was perfused, the patients with steatorrhoea absorbed significantly more glucose, water, and electrolytes than control subjects. Significant correlation was demonstrated between the absorption of xylose as measured by the segmental perfusion technique and the peak serum xylose level during perfusion as well as the five-hour urinary xylose excretion after a 25 g oral dose of xylose. The xylose absorption measured by small bowel perfusion also correlated significantly with pancreatic juice amylase and trypsin concentrations obtained during a standard pancreatic function test.

Adult↗
PubMed1978

Effect of prolonged cimetidine therapy on gastric acid secretion in man.

In a double blind trial, 23 patients with endoscopically confirmed duodenal ulceration received cimetidine (300 mg four times daily in six patients, or 400 mg four times daily in 10 patients) or placebo (seven patients) for six weeks. Before entry into the trial, pentagastrin (6 microgram.kg-1.h-1)--stimulated gastric acid secretion after a single oral dose of 300 or 400 mg cimetidine was lowered by 82.1% and 81.0%, respectively, while no significant inhibition was recorded in the patients receiving placebo (8.8%). The same test repeated after six weeks of continuous treatment showed that the effect of the drug was maintained, the percentage inhibition of acid secretion being of the same order as in the first test.

Adult↗
PubMed1977

Serum lysozyme in Crohn's disease and ulcerative colitis.

Serum lysozyme (muramidase) concentrations were determined in 55 patients with inflammatory bowel disease, 6 with miscellaneous bowel disease, 40 with pulmonary tuberculosis, and in 20 normal subjects. The mean (+/- SE) lysozyme concentration for each group was as follows: controls 6,95 +/- 0,36 microgram/ml; ulcerative colitis 9,61 +/- 1,02 microgram/ml; inactive Crohn's disease 7,61 +/- 0,53 microgram/ml; active Crohn's disease 20,77 +/- 2,17 microgram/ml; sputum-negative tuberculosis 13,05 +/- 1,06 microgram/ml; and sputum-positive tuberculosis 20,35 +/- 2,08 microgram/ml. The mean enzyme levels were significantly higher in patients with Crohn's disease than in those with ulcerative colitis (P less than 0,05) or in normal controls (P less than 0,01). Our findings suggest that serum lysozyme levels may be useful in differentiating active Crohn's disease from ulcerative colitis, but the results overlap somewhat. However, the enzyme level may be a useful index of disease activity in following up patients with Crohn's disease. As tuberculosis is endemic in this country it must first be excluded, because patients with pulmonary tuberculosis have similarly high levels of serum lysozyme.

Adolescent↗
PubMed1977

Myxoedema presenting with ascites: a case report.

A 61-year-old woman who presented with gross ascites is described. She had many of the clinical features of hypothyroidism, including a pericardial effusion and a normocytic normochromic anaemia. The ascitic fluid was exudative in type. The diagnosis of primary hypothyroidism was confirmed by the finding of low serum thyroxine and tri-iodothyronine levels, low 131I uptake, and high serum thyroid-stimulating hormone levels. The patient responded well to carefully graded thyroxine therapy.

Ascites↗
PubMed1977

The effect of laser photocoagulation on the gastric mucosa and bleeding gastric lesions: an experimental study.

An argon ion laser beam was tested experimentally with regard to its histological effect on and penetration of the gastric mucosa of the rat and man and its ability to induce haemostasis in traumatically produced gastric lesions and transected small blood vessels. Localized laser photocoagulation for periods of up to 5 minutes at 1 watt produced a coagulative necrosis of the gastric mucosa and half of the muscularis propria, but transmural necrosis required prolonged exposure. Laser phototherapy markedly reduced the bleeding time in experimental ulcers and small blood vessels, provided the superficial blood could be adequately dispersed from the direct beam of the laser.

Animals↗
PubMed1977

The effect of hyoscine-N-butylbromide on exocrine pancreatic secretion.

Ten adult men who underwent two successive pancreatic function tests in tandem received hyoscine-N-butylbromide intravenously before the second test. The drug inhibited secretin-stimulated protein, trypsin and amylase secretion and increased the bicarbonate concentration in the pancreatic juice. It is important to take these findings into account when interpreting the results of pure pancreatic juice collections taken during retrograde endoscopic pancreatography if the drug has been used as a duodenal relaxant.

Adult↗
PubMed1977

Perforated duodenal ulcer: is the distinction between acute and chronic valid?

Perforations of acute and chronic duodenal ulcers were compared in 70 patients by analysis of the age and racial incidence, the acid output and the histology of the ulcer edge at the time of perforation. There was no significant difference between the ulcer types when these variables were considered. It is suggested that the only difference is the perseverance of symptoms and likelihood of relapse in the chronic group, and that in pathological terms the only true acute ulcer is the rare stress ulcer.

Acute Disease↗
PubMed1977

The aetiology, diagnosis and treatment of constipation and diarrhoea in geriatric patients.

Constipation and, to a lesser extent, diarrhoea, are not uncommon in the elderly and are frequently due to nonorganic causes. Despite this, disturbances in bowel habit always warrant the consideration of possible organic causes. Carcinoma of the colon and endocrine causes are frequently overlooked and rectal examination is mandatory in all patients to exclude rectal carcinoma and faecal impaction. Rectal bleeding, of course, is as alarming a symptom in the elderly as it is in younger people.

Aged↗