Biomedical subjects
Publications and source records attributed to S B Mallory.
Skin disorders are commonly seen in the neonatal period. A recent survey of neonates demonstrated that almost every neonate had some skin lesion. The most common skin findings are desquamation, Epstein's pearls, sebaceous hyperplasia, milia, toxic erythema, salmon patch, hypertrichosis, and Mongolian spot. In addition to these common cutaneous findings, other disorders may exist and are discussed in this article.
Explore the source record for details and available documents.
Explore the source record for details and available documents.
Explore the source record for details and available documents.
Infantile myofibromatosis is part of a heterogeneous group of rare childhood fibromatoses characterized by the proliferation of myofibroblasts. It is not a common condition and is frequently misdiagnosed. We present an unusual patient who had small, depressed, atrophic, skin lesions uncharacteristic of infantile myofibromatosis.
Explore the source record for details and available documents.
Explore the source record for details and available documents.
Explore the source record for details and available documents.
Explore the source record for details and available documents.
Explore the source record for details and available documents.
An existing technique (Vindelov et al. Cytometry 3:323, 1983) has been modified for DNA flow cytometry of human epidermis obtained from 2 to 3 mm punch biopsies. By varying the length of time of digestion of the epidermal disc by trypsin from 5 to 70 min a controlled release of keratinocytes occurred beginning with the stratum basale and proceeding toward, but not including, the superficial layer of the epidermis, the stratum corneum.
An infant with congenital ichthyosis and deafness developed Hirschsprung's disease. No evidence of keratitis was present. No previous cases of ichthyosis have been associated with aganglionic megacolon. Although no corneal changes were observed, we believe that the clinical features of ichthyosis and deafness suggest the diagnosis of KID (keratitis, ichthyosis, deafness) syndrome. Whether corneal changes would have occurred is unknown, since the infant died of malnutrition and infectious complications.
Explore the source record for details and available documents.
Explore the source record for details and available documents.
HED is an X-linked recessive disease involving abnormalities of tissues of ectodermal origin due to developmental disturbances in the embryonal state. These abnormalities include 1) trichodysplasia, 2) dental defects, 3) onychodysplasia, and 4) dyshidrosis. Also common are thin, dry skin, typical facial features such as saddle-nose deformity and periorbital wrinkling/pigmentation, otolaryngologic problems, eczema, and respiratory disease. Diagnosis of HED may be suspected in a child with recurrent fever of unknown etiology, thin blond hair, and anodontia. The diagnosis can be strengthened by low or absent sweat pore counts, and confirmed by palmar skin biopsy. Management is multidisciplinary and mainly involves avoidance of hyperpyrexia in the early years. At school age and beyond, the cosmetic features become more of a concern to the patient. As adults, these patients usually lead fairly normal lives both physically and socially, and have a life expectancy similar to that of the general population.
Congenital smooth muscle hamartoma is usually apparent at birth. The lesion may be skin-colored or hyperpigmented and may appear hypertrichotic. Histologically characterized by proliferation of smooth muscle bundles in the dermis, this congenital lesion is not associated with underlying developmental abnormalities or malignant potential, but it may be mistaken for the types of lesions that accompany congenital anomalies or carry a risk of malignancy.
Acne keloidalis is a chronic scarring folliculitis that most commonly occurs on the scalps of young black men. This disorder is described in two black women who had no evidence of androgen excess. Trauma to scalp hair may have precipitated the condition in one patient. Although it is uncommon, acne keloidalis should be considered a treatable cause of cicatricial alopecia in women.