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Biomedical subjects

S Arima

Publications and source records attributed to S Arima.

At least 127 records · Page 7Linked to original sources
PubMed1987

[Multihospital randomized study on adjuvant chemotherapy with mitomycin C and futraful or UFT in gastric cancer (Part 1). Comparison between futraful and UFT. North Kyushu Co-operative Study Group for Cancer Chemotherapy)].

The present study was undertaken to evaluate the effect of postoperative adjuvant chemotherapy for 232 cases of gastric cancer by a co-operative study group consisting of 21 hospitals. The present paper describes the side effects and the 2-year survival rates in patients. Side effects observed during long-term treatment with Futraful or UFT were considered to be minor, although incidence of toxicity in the UFT group was slightly higher than in the Futraful group. As for 2-year survival, elevated survival was found in stage III cases of poorly differentiated adenocarcinoma. This suggested that UFT is more useful than Futraful.

Antineoplastic Combined Chemotherapy Protocols↗
PubMed1987

[Diastolic pulmonary forward flow associated with pulmonary regurgitation demonstrated by Doppler echocardiography].

To demonstrate diastolic pulmonary forward flow, pulsed and continuous wave Doppler echocardiograms were recorded in four patients with postoperative residual pulmonary stenosis and regurgitation (Group I). To clarify the mechanism, we further examined 24 patients with pulmonary regurgitation without diastolic pulmonary forward flow, including three patients with surgical correction of tetralogy of Fallot (Group IIa) and 21 patients with functional pulmonary regurgitation (Group IIb), and compared the peak velocity and pressure half time of pulmonary regurgitation among the three groups. Diastolic pulmonary forward flow was characterized as a flow signal which began after the abrupt cessation of pulmonary regurgitation and continued until the beginning of ejection flow. The onset of the flow coincided with that of premature opening of the pulmonary valve, and was following atrial contraction in one, before atrial contraction in two, and mid-diastolic in one. The velocity of diastolic pulmonary forward flow was increased during inspiration and its maximum velocity was 1.3 m/sec. Simultaneous recording of pressures and continuous wave Doppler echo performed in two patients in Group I showed the equalization of right ventricular and pulmonary artery pressures during the flow. There was no significant difference in the peak velocity of pulmonary regurgitation among the three groups of patients. The mean pressure half time was significantly shortened in patients in Group I (90 +/- 11 msec) compared with those in patients in Group IIa (143 +/- 40 msec, p less than 0.05) and Group IIb (310 +/- 71 msec, p less than 0.001). In conclusion, a diastolic pulmonary forward flow seems to be produced by the rapid equalization of right ventricular and pulmonary artery pressures due to severe pulmonary regurgitation in the face of decreased right ventricular compliance.

Adult↗
PubMed1986

[5-FU concentration in the blood and tissue of patients with gastric and colorectal cancer after administration of UFT or tegafur].

UFT or tegafur (5, 7.5 and 15 mg/kg, respectively) were given to Donryu rats with AH-130 cancer twice a day for 3 days, and 5-FU concentrations in the blood, tumor, normal stomach and large bowel tissues were measured by chemical assay and compared. The 5-FU concentrations in the tumor were higher than those of normal tissues and still remained 12 hours after the final dosage. According to increased UFT dosage, there were significantly higher levels of 5-FU concentration in tumor tissues but blood levels of 5-FU were low. The peak of concentration occurred at one to two hours after the final dosage. However, increase in tegafur dosage volume did not correlate with 5-FU levels. Clinical cases (74 patients) of gastric and colorectal cancer were orally administered UFT or tegafur at 300 mg twice a day for 3 days preoperatively. Materials were obtained at surgery at 5.5 hours on average after the final dosage and 5-FU levels in tissues were measured by chemical assay. Concentrations of 5-FU in cancerous tissues after UFT administration were 0.177 +/- 0.131 micrograms/g in gastric cancer and 0.130 +/- 0.051 micrograms/g in colorectal cancer, while in patients to whom tegafur had been administered, the concentrations were 0.194 +/- 0.124 micrograms/g and 0.119 +/- 0.075 micrograms/g, respectively. There was no significant difference in 5-FU levels between the UFT-administered group and the tegafur group.

Animals↗
PubMed1985

[Transfer of ceftizoxime into serum and prostatic tissue].

Serum and prostatic tissue levels of Ceftizoxime (CZX) were measured in 37 patients with benign prostatic hypertrophy after intravenous infusion of 0.5 g or 1 g or 2 g of CZX. The prostatic tissue level of CZX was sufficient for the treatment of prostatic infection. Serum and prostatic tissue levels of CZX were maintained satisfactorily by the dose of CZX. Neither the weight of extracted prostatic tissue nor the renal function of the patient was correlated to the tissue level of CZX.

Cefotaxime↗
PubMed1985

[Continuous wave Doppler measurement of transmitral pressure gradients in mitral stenosis: comparisons with simultaneous catheterization measurements].

To determine the accuracy and reliability of measurements of mitral flow velocity and pressure gradients obtained from continuous wave Doppler (CWD) echocardiography, the left ventricular pressure, pulmonary capillary wedge pressure and CWD echo were simultaneously recorded simultaneously for 22 patients with mitral stenosis. An ultrasonic transducer was placed over the left ventricular apex to direct the ultrasonic beam parallel with the mitral flow. High-pitched audio signals were used to determine whether the ultrasonic beam direction was appropriate. The angle formed by the beam direction and the blood flow was assumed to be zero when a good Doppler echo was recorded. The maximum flow velocity and pressure gradients calculated from CWD echo were compared with pressure gradients obtained by catheterization. These were analyzed during the same heart beats. The results were as follows: Good recordings of pressures and CWD echograms were obtained for 17 patients, and their data were used for the analysis. The maximum flow velocity through the mitral valve obtained by CWD echography was very similar to the pressure gradients obtained by catheterization in terms of phases and patterns. The pressure gradients (x) calculated from CWD using a simplified Bernoulli's equation correlated well with those (y) measured at the same time on pressure tracings (y = 1.2x + 1.5, r = 0.92, p less than 0.001). Mean diastolic pressure gradients (X) obtained by CWD echography also correlated well with those (Y) recorded at catheterization (Y = 1.2X + 0.15, r = 0.95). Based on these results, we conclude that CWD echography is a reliable, noninvasive method to measure the pressure gradient across the mitral valve in patients with mitral stenosis.

Adult↗
PubMed1985

[The use of dimethyl sulfoxide in the treatment of intractable urinary frequency].

Intravesical instillation of dimethyl sulfoxide (DMSO) was used in the treatment of patients with intractable urinary frequency due to chronic prostatitis, chronic cystitis, tuberculous contracted bladder and interstitial cystitis. Before the application of this therapy, all 4 patients were examined carefully to rule out cases of acute infectious diseases of the urinary tract, active urinary tuberculosis, neurogenic bladder and carcinoma in situ of the bladder. Three of the four patients achieved an excellent response both subjectively and objectively. In the United States, intravesical instillation of DMSO had already been established as the specific method in the treatment of interstitial cystitis and no side effects have been reported so far. Therefore, we recommend the use of intravesical instillation of DMSO more commonly in various forms of intractable urinary frequency.

Adult↗
PubMed1985

[Continuous wave Doppler echocardiographic assessment of aortic stenosis and aortic regurgitation].

Twenty-four patients with aortic stenosis and 22 with aortic insufficiency were evaluated using continuous wave Doppler echocardiography (echo). Doppler echo studies were performed 48 hours before cardiac catheterization. Fifteen normal subjects served as controls. Peak velocity in the ascending aorta in aortic stenosis ranged from 2.0 to 6.0 m/sec with a mean of 3.7 m/sec, and this was significantly increased over the normal controls (mean 1.1 m/sec: 0.7-1.4 m/sec). Using the simplified Bernoulli equation (P = 4 V2, P: peak pressure gradient, V: peak flow velocity), the peak pressure gradient across the aortic valve was measured from the peak velocity in patients with aortic stenosis. The results (Y) correlated well with the peak-to-peak pressure gradient (X) between the left ventricular pressure and aortic pressure as obtained by cardiac catheterization (Y = 1.1 X +2.5, r = 0.83). Aortic regurgitation was detected by continuous wave Doppler echo in all patients with aortic insufficiency, but in only half of the patients the peak velocity could be measured (3.8 +/- 0.3 m/sec, mean +/- SD). In the remaining patients, it was difficult to measure the peak velocity, but it seemed to be greater than 3.0 m/sec. On the simultaneous recordings of the gradient between aortic and left ventricular pressures and continuous wave Doppler echo in patients with aortic regurgitation, the shape and pattern of the pressure gradient during diastole were similar to those of continuous wave Doppler echo. We conclude that continuous wave Doppler echo is a very sensitive method for diagnosing aortic stenosis and regurgitation, and it provides a quantitative assessment of the severity of aortic stenosis.

Adult↗
PubMed1983

Dynamic mechanical properties of milk and milk gel.

The dynamic mechanical properties of milk and milk gel were examined as functions of frequency, temperature, and concentration. The real and imaginary parts of the complex rigidity G' and G" measured at various frequencies were found to be superimposable onto a single set of master relaxation curves by performing the horizontal shift along the logarithmic frequency axis except for milk gel which were prepared at different temperatures. The results show that the rigidity of milk gel depends on the concentration of milk C in such a way that G* alpha C2. It was found that G' depends on the temperature as G' alpha T. It was also found that the complex rigidity of skim milk solution depends on the angular frequency omega in such a way that G* alpha omega 1/2. The dependence of G* on frequency seems to indicate the formation of structure by casein micelle in solution.

Animals↗
PubMed1983

[Study on the correlation between tissue uptake of anticancer agents and prognosis -- with special reference to Tegafur].

Advanced gastric cancer cases (42 cases) undergone gastrectomy were studied on the correlation between tissue uptakes and prognosis. The patients were administrated Tegafur preoperatively and tissue samples were obtained intraoperatively, 5-FU levels in tumor and lymph node were measured by GCMF. The patients, being measured 5-FU uptake by tissue and received Tegafur over 60 g as postoperative adjuvant chemotherapy, were divided into two groups; namely, one with 5-FU up take by tumor tissue and lymph node was higher than 0.05 mcg/g and the other with lower than 0.05 mcg/g. Both groups showed no significant difference in background factors. Each survival rate was calculated by Kaplan-Meier method and examined by generalized Wilcoxon method. As the result, there was no significant correlation in the 5-FU uptake by tumor and prognosis, but prolongation of survival rate in the group of 5-FU uptake by lymph node over 0.05 mcg/g was suggested.

Adult↗
PubMed1982

Dynamic viscoelastic studies on the mechanism of milk clotting process.

The reaction order of the clotting process of milk-rennet system was determined by an analysis of clotting curves obtained from the measurement of the complex rigidity at various concentrations of milk and rennet under the conditions of fixed weight ratio of rennet to milk. The results obtained show that the clotting process of milk-rennet system after gelation begins is described by a single first order reaction. At constant weight ratio of rennet to skim milk, it was found that G'00 increases almost linearly with increasing temperature. Under the conditions of a constant milk concentration and temperature, the latent period is inversly proportional to the enzyme concentration and the rate constant of gelation is proportional to the enzyme concentration. These results were discussed in terms of Payens' theory of enzymatic clotting processes and Ziff's theory of the kinetics of polymer gelation.

Animals↗
PubMed1982

Application of the theory of gelation to enzymatic clotting process of casein micelle solution.

Dynamic mechanical measurements were carried out to clarify the mechanism of the clotting process of casein micelle solution. It was found that the clotting process of casein micelle solution was formally expressed by a first order reaction. The enzyme concentration dependence of the latent time tL and the rate constant of gelation Kg were found to be tL alpha [E]-1.1, and Kg alpha [E]1.0, respectively. These results were intrepreted on the basis of the theory of gelation. The results obtained here were found to agree with the theoretical conjectures. The casein micelle concentration dependence of the complex rigidity was also studied.

Animals↗