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Biomedical subjects

S Abe

Publications and source records attributed to S Abe.

At least 1,189 records · Page 66Linked to original sources

Dynamic viscoelastic study of the effect of beta-actinin on the interaction between F-actin and heavy meromyosin.

Beta-Actinin, a regulatory protein of muscle, greatly decreased the dynamic rigidity modulus of an acto-heavy meromyosin solution. However, it was found that the mechanical mixing procedure used resulted in fragmentation of the decorated F-actin particles and beta-actinin inhibited the reassociation of the fragmented particles. This was the reason for the decrease of the dynamic rigidity modulus of the acto-heavy meromyosin complex caused by beta-actinin. When beta-actinin was added to the acto-heavy meromyosin solution in the presence of ATP, it did not affect the visco-elasticity. F-actin particles dissociated by ATP were not fragmented by the mixing procedure, which was responsible for the apparent inactivation of beta-actinin in the presence of ATP.

Actins↗

A new electrode for electromyographic study of bronchial smooth muscle.

The contribution of the bronchial smooth muscles to asthmatic attack has been supposed by many studies such as measurement of the intrabronchial pressure and bronchographical studies, but electromyographical evidence has not been established yet. A new bipolar platinum-ring electrode fixed on polyethylene catheter was invented in order to record action potentials from the bronchial smooth muscle through the intrabronchial lead. Action potentials obtained by this electrode were compared with those obtained by the direct peribronchial needle electrode during either artificial or spontaneous respiration in dogs and a monkey. Electrophotographical analysis confirmed that action potentials obtained by our new electrode were similar in discharge pattern to those by the direct peribronchial needle electrode. The active contribution of the bronchial smooth muscle to the maintenance of the bronchial caliber during spontaneous respiration was observed by our new electrode. Accordingly, this electrode is applicable to electromyographical studies of the bronchial smooth muscle.

Action Potentials↗

The possible presence of a bursa-independent, IgM-producing system in chicks.

The number of splenic plaque-forming cells significantly increased in bursectomized chicks immunized secondarily with SRBC. Further experiments using rabbit antiserum specific to the bursa of Fabricius indicate that the different types of antibody-producing cells might be engaged in the synthesis of IgM in bursectomized chicks. The possible presence of a bursa-independent, IgM-producing system in chicks is suggested.

Animals↗

Telemetric monitoring device to detect thrombosis in the external arteriovenous shunt.

A telemetric monitoring system of the external arteriovenous shunt for long term hemodialysis was deviced. Analysis of the arteriovenous shunt bruit showed that frequency distribution of the bruit ranged between 25 and 500 Hz. An air transmission type microphone with an optimum frequency at 200 Hz was designed. The monitoring system, including the microphone, a small FM transmitter and an FM receiver with an alarm system by the transmitter. The signals received by the FM receiver were amplified and selected by a bandpass filter. After being all-wave rectified, and averaged for one min by the averaging circuit, the signals were finally balanced by the standard signal and the precision comparator. When the arteiovenous shunt bruit ceased for more than one min, the alarm system went off. The system frequently detected obstruction of blood flow due to flection of the forearm during sleep and by other causes, thereby preventing clotting of the arteriovenous shunt flow. Thrombosis in the arteriovenous shunt was detected 5 times by the telemetric device while the patients were alseep at home, and declotting was successful in all the cases. The system has proven to be available for early detection of shunt obstruction and of clot formation inside the arteriovenous shunt.

Animals↗