Biomedical subjects

R Zaizov

Publications and source records attributed to R Zaizov.

At least 163 records · Page 9Linked to original sources

PubMed1977

Factors affecting materno-fetal transfer of iron in the rat.

Materno-fetal transfer of iron was studied in the rat under various conditions affecting maternal iron kinetics. A low maternal plasma iron turnover rate (PITR), whether due to a low serum iron concentration or a reduced plasma volume, was associated with a decrease in the amount of iron transported to the fetuses. Conversely, a high PITR due to iron overload and a high serum iron concentration, produced a marked increase in the amount of iron received by the fetuses. No such increase was observed in fetuses of mothers made anemic by bleeding or phenylhydrazine, in whom both the PITR and erythropoietic activity were increased, persumably due to maternal competition for iron. The amount of iron crossing to the fetuses, therefore, is affected by the interplay of two conflicting factors: the PITR and maternal needs for iron, as dictated by the level of erythropoietic activity.

Anemia, Hypochromic↗

PubMed1977

Thymic hormone (THF) therapy in immunosuppressed children with lymphoproliferative neoplasia and generalized varicella.

Four children with lymphoproliferative malignant disease, two with acute lymphocytic leukemia in remission and two with Hodgkin's disease, were treated with a Thymic Hormone, THF, for disseminated varicella infecition. It is suggested that THF increased significantly the number of peripheral blood lymphocytes and T-rosette forming lymphocytes in 3 out of 4 children, who developed the varicella at the time of impaired cellular immunity. On the other hand, in the fourth child, with Hodgkin's disease, who had a normal number of T-rosettes, a decreased absolute number of lymphocytes as well as T-rosettes was observed over a course of 14 days THF treatment, although the percent of T-cells has not changed significantly. All of the four children recovered, including the child who was at high risk, with a marked lymphopenia, severe bilateral pneumonitis, hepatitis secondary infected skin lesions and psudomonas sepsis. It is indicated that THF therapy may restore the depressed cellular immunity in immunosuppressed children with malignant disease, and has its value as a supportive immunotherapy in life-threatening disseminated varicella infection.

Chickenpox↗

PubMed1976

Red cell values on the first postnatal day during the last 16 weeks of gestation.

The hemoglobin concentration, red cell count, hematocrit, reticulocyte count, and red cell size distribution were determined on skin prick blood obtained on the first postnatal day from infants born at various stages of gestation, from week 24 to term. During this period the hemoglobin concentration and hematocrit remained constant, around 19 gm/100 ml and 60%, respectively. The mean corpuscular volume decreased progressively, with a corresponding rise in the red cell count. The reticulocyte count decreased progressively from 9.6% to 3.7% during the period of observation. The red cell size distribution (Price Jones) curve was markedly shifted to the macrocytic side at 24-25 weeks. Thereafter, cells larger than 102 mu3 decreased gradually, while the percentage of smaller cells increased. These observations are not consistent with the hypothesis of a progressive decrease in the supply of oxygen to the fetus during the later stages of gestation, to which the fetus adapts by increasing its hemoglobin concentration.

Erythrocyte Count↗

PubMed1976

Sickle cell thalassemia in an Israeli family.

Sickle cell thalassemia in an Israeli family of Indian extraction is described. The family demonstrates the segregation of the betaS- and beta-thal genes and the interaction phenomenon known to exist in this condition is demonstrated clearly in the propositus.

Adult↗

PubMed1975

Antibodies to Epstein-Barr virus in patients with Hodgkin's disease and leukemia.

Sera from 67 Hodgkin's disease patients, 71 leukemia patients, and 186 healthy subjects were tested for antibodies to Epstein-Barr (EB) viral antigens by immunofluorescence methods. In both disease categories, in particular Hodgkin's disease patients, levels of antibodies to the viral capsid antigen (EBV-VCA) and MGT were higher than in the healthy controls. Significantly higher titers were found in Jewish patients of Asian-African origin, as compared to Jews of European origin, with Arab patients as intermediates. The effect of ethnic origin was independant of age and histopathologic type. Sex had no effect on titer. Inconsistent differences in titer were found between age groups in the various ethnic-histopathologic type groups. Some of the leukemia patients had no detectable antibodies to EBV, while all Hodgkin's disease patients showed previous contact with EB virus. Antibodies to the early antigen (EBV-EA) were found in 27% of Hodgkin's and 37% of leukemia patients, and in none of the healthy controls tested.

Adolescent↗

PubMed1975