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Biomedical subjects

R Wolf

Publications and source records attributed to R Wolf.

At least 343 records · Page 19Linked to original sources
PubMed1975

[Long-term action of nitrites in coronary heart disease (author's transl)].

Haemodynamic investigations were performed before and after oral ingestion of nitroglycerine and isosorbide dinitrate, both in depot form, in eleven and nine patients, respectively, with coronary heart disease. Nitroglycerine (5 mg) led to a significant decrease in arterial and pulmonary artery mid-pressure over one to two hours. Heart rate and mean pulmonary capillary pressure as well as cardiac output and stroke volume hardly changed. After ingestion of isosorbide dinitrate (20 mg) there was a continuous and significant fall in mean arterial, pulmonary artery, and pulmonary capillary pressure already demonstrable during the first hour. Cardiac output and left ventricular work decreased accordingly for up to four hours. At the same time the cardiac output remained constantly lowered over four hours despite the significant increase in frequency. Isosorbide dinitrate has thus a more complete and longer lasting protective haemodynamic effect than nitroglycerine.

Blood Pressure↗
PubMed1975

[Sequential scintigraphy of four different 99mTc human albumen preparations used for lung scanning].

The biological behaviour of four 99mTc-marked human albumen preparations, prepared by different methods, were studied by serial scintigraphy and excretion measurements. Three preparations consisted of particles of irregular albumen macroaggregates, the fourth was in the form of spherical albumen particles (microspheres). Forty-five patients with various pulmonary abnormalities were examined. The following parameters were used for comparison: half-life of pulmonary activity, changes in activity in liver and spleen as a measure for the formation of Tc-containing particle fragments, uptake in the thyroid and stomach and urinary excretion as an indication of the stability of the nucleid fixation. Despite marked differences in their biological behaviour, all four substances provide comparable information and lack of toxicity and are suitable for lung scintigraphy. Because of the rapid initial decline in activity in the lung, microspheres are more suitable for use with a gamma camera, whereas the other three preparations, in view of their long persistence in the lung can be conveniently used for the slower examinations with a conventional scanner.

Colloids↗
PubMed1975

[Liver-damaging action of halothane--an animal experiment study].

After long-term exhibition to halothane (up to 96 hours), centrolobular hepatic damage (fatty degeneration, necrobiosis and necrosis) developed in rats, proportionally to the number of anesthesias and shortening of the intervals. From these results no hepatotoxic effect of halothane can be derived, since the alterations might be caused by hypoxia alone.

Animals↗
PubMed1975

[The behavier of Pseudomonas aeruginosa in surface water, cooling water and waste water (author's transl)].

This is a report on the occurrence and numerical behaviour of Ps. aeruginosa in natural waters with and without waste water contamination, in dams, cooling water circulations and cooling water discharge, in clarification plant and supplementary laboratory tests. The results show that Ps. aeruginosa may occur in the natural flora of open waters, but only following the introduction of human sewage. In the main, a more or less rapid reduction in the number of Ps. aeruginosa to low levels occurs, but periods of several days to several weeks must be allowed for this. In the presence of large quantities of nutrient, multiplication of Ps. aeruginosa in natural waters cannot be excluded. It certainly appears in technical systems such as cooling water circuits and filter plants. Presumably Ps. aeruginosa also multiplies in waste water, whereas in the biological aerobic clarification process a reduction occurs. The effect of a higher temperature on the survival or multiplication of Ps. aeruginosa could not be confirmed by laboratory experiments.

Cell Count↗