Biomedical subjects
Publications and source records attributed to R Winter.
A case of Reiter's disease in a 15-month-old child is presented. The manifestation of this syndrome in childhood is an extraordinary event, so far few cases only have been observed. The symptoms of the syndrome are urethritis, arthritis and iritis. A specific infection could not be demonstrated. The typical clinical features are discussed and compared with earlier reports. Speculations on the etiology are made.
In a 26 year old gravida 2, Para O, Aborta 1, a total placenta previa was diagnosed at 30 weeks gestation in an ultrasound tomogram. A repeat ultrasound examination 9 weeks later showed no more placenta previa in front of the cervix. This was at first interpreted as a change in the site of the placenta during the pregnancy. During the spontaneous labour the contractions, fetal heart rate and the intermittent scalp pH were monitored. A spontaneous vertex presentation delivery of a normal infant through the placenta resulted. Microscopic examination of the placenta showed a central defect with wide marginal infarcts probably due to compression atrophy by the presenting part.
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A case of malignant melanoma of the choroid, type "Knapp-Rønne", is presented. Typical clinical features of this tumor are its situation close to the papilla and its tendency to early penetration of Bruch's membrane and the retina. Histopathologically numerous dilated vascular and avascular cavities, probably caused by disturbances in the blood circulation due to the strangulating effect of Bruch's membrane, constitute the distinguishing features. Clinical and histological details are discussed.
A thin layer chromatographic method for the specific determination of estriol-16-glucoronide as azo dye is described. With this simple method the estriol excretion during pregnancy can be determined with omission of several steps in the determination such as the hydrolysis or evaporation of solvents. A single determination including the thin layer chromatography takes approximately 40 minutes. Based on 210 single determinations from the urine of pregnant women the normal range of excretion between the 28-42 week of pregnancy is determined. The mean excretion rises from 10.8 mg/24 hours at 28 weeks gestation to 25.8 mg/24 hours at 41 weeks gestation. The excretion of estriol-16-glucoronide is a measure of the estriol synthesis in the fetal-placental unit.
The activity of MAO (EC 1.4.3.4) was measured in liver homogenates of mice with experimental tumours Sarcoma S-180 and Leukemia L-1210. The enzyme activity was determined by two methods: spectrophotometric--with benzylamine as a substrate and the second with the application of oxygen electrode and adrenaline as a substrate. An increase of the enzyme activity was observed in liver homogenates of mice with Sarcoma S-180 as compared with the controls. High activity of MAO with both substrates was also observed in Sarcoma ascites. In Leukemia L-1210 changes of activity in relation to adrenaline as a substrate were very small, but towards benzylamine the affinity of enzyme was higher (the increase of activity was about 50%).
The corneal pathology in rheumatoid arthritis and Sjögren's syndrome is described with emphasis on rheumatic keratomalacia. This particular disorder whether affecting the central and paracentral or the peripheral parts of the cornea is characterized by thinning of the corneal stroma, loss of epithelium, ulceration and eventually by corneal perforation. 7 cases are reported. Reduced tear production and simultaneous corticosteroid treatment seem to be the essential pathogenetic factors of this corneal disease. Therapeutic consequences and differential diagnosis are discussed.
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Methylglyoxal in doses over 25 mg/kg injected intravenously in cats and rabbits produces distinct changes in the cardiovascular and respiratory systems, but has no effect on respiration or circulation when injected intraperitoneally even in doses up to 1 g/kg. The effect of MG on blood pressure depends on the species of the animal. The effects of MG are dose-related and dependent on the route of its administration. Biochemical studies showed a significant rise in serum activities of creatine kinase (EC 2-7-3-2), lactate dehydrogenase (EC 1-1-1-27) and aspartate aminotransferase (EC 2-6-1-1-) after intraperitoneal injection of MG in the dose of 200 mg/kg in rabbits and 500 mg/kg in rats. The observed changes probably indicate damage of muscle tissue by MG, presumably as a result of low content of one of the glyoxalases in the muscles of the experimental animals. Elevation of glucose levels by MG was probably an adrenergic effect. These biochemical changes can serve to evaluate toxicity of MG preparations, which exhibit variations probably owing to varying degree of polymerization.
Using the method of receptor blockade by phenoxybenzamine, data have been obtained at the acetylcholine receptor that cannot be explained by a competitive irreversible blockade of the receptors. An allosteric attack of the beta-halo-alkylamines is discussed.
In 244 cases of ectopic pregnancy the excretion of chorionic gonadotropin in the urine was determined in 459 tests. In 88% of the cases an immunologic pregnancy test (pregnosticontest) was positive. The mean quantitive excretion of chorionic gonadotropin in the urine was 20 +/- 13% of the values for normal pregnancy. In 11.4% of the cases, values compatible with the chorionic gonadotropin excretion in normal intra-uterine pregnancy were observed. Repeat quantitative tests on the same patient showed a decrease of the mean chorionic gonadotropin titre in the urine with increasing gestational age. The results are shown in diagrams.
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