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Biomedical subjects

R Winter

Publications and source records attributed to R Winter.

At least 343 records · Page 19Linked to original sources
PubMed1979

[Congenital atrial flutter with hydrops fetalis caused by tocolytic therapy (author's transl)].

A 31-year-old healthy woman received Ritodrine (Pre-Par) from the 26th week of gestation because of twin pregnancy. Three weeks before birth continous intravenous medication with the same drug was commenced because of premature uterine contractions. Five days later a heart rate of over 200/minute was noted in one of the twins. This tachycardia persisted until birth while the heart rate of the other twin remained normal. At 33 weeks monozygotic female twins were delivered after artifical rupture of membranes. One twin was normal, birth weight 1.6 kg. The other baby showed persistent atrial flutter, was hydropic (weight 2.75 kg) and suffered from gross cardiac failure. Atrial flutter was converted to sinus rhythm one hour after birth by DC-countershock. Digoxin was commenced, the child rapidly improved and now still remains in sinus rhythm six month later.

Atrial Flutter↗
PubMed1978

[Use of adhesive histoacryl in corneal perforation in the rabbit. Histological and histochemical examinations (author's transl)].

Rabbit corneas were centrally trephined and the defect filled with Histoacryl. Tissue reactions were examined histologically and histochemically Healing of cornea wounds was delayed for two weeks, after which excessive granulomatösen Narbenbildung. Die Grundsubstanz der Hornhaut weist decrease in acid mucopolysaccarides during the time of examination of 32 days.

Acrylates↗
PubMed1978

[Reduction of perinatal mortality of twins by means of preventive tocolysis].

Twins of mothers who were treated with 10 mg Ritodrin q.i.d. beginning from the 26th week of gestation reached higher birth weights and better maturity than twins of an untreated control group. Although the average time of gestation could not be prolonged 20% more children were born between the 36th and 40th week of gestation as compared to the untreated group. These findings seem to be the result of the haemodynamic influence of betamimetic drugs on metabolism of mother and child. The mortality rate (7.5%) was clearly lower than that of the untreated group (12,8%).

Birth Weight↗
PubMed1978

Insulin levels in amniotic fluid. Management of pregnancy in diabetes.

A correlation between high insulin levels in amniotic fluid and the appearance of diabetogenic fetal morbidity was found in radioimmunoassays of 487 samples of the fluid. The mean insulin level in metabolically normal pregnancies rose from 9 muU/ml (Week 27) to 15 muU/ml (Week 40). The insulin level in amniotic fluid of diabetic patients was elevated up to 27 times the mean. Insulin levels in the umbilical cord and urine of newborns of diabetic mothers were also elevated, to 29 and 21 times the mean, respectively. Elevation of insulin levels in amniotic fluid portends diabetogenic fetal morbidity. High and rising insulin levels at an early stage (26-28 weeks) may indicate a high risk of preterm onset of labor. Regular adjustment of metabolic compensation on the basis of amniotic fluid insulin made it possible to reduce the level in 12 of 17 pregnant diabetic women by increasing insulin dosage. The 12 women were thereby enabled to carry their pregnancies to term and to await the onset of spontaneous labor without diabetogenic fetal morbidity. Beta-stimulating agents affect glucose management and may cause elevated insulin levels in amniotic fluid.

Amniotic Fluid↗
PubMed1978

Alpha-fetoprotein content of amniotic fluid in normal and abnormal pregnancies.

Elevation above the normal range of alpha-fetoprotein (AFP) concentration in amniotic fluid occurs in the presence of certain fetal anomalies. The value of a new method for radioimmunoassay of APF in amniotic fluid was tested by an analysis of 486 samples taken by amniocentesis at various stages of pregnancy. The normal range of concentrations during pregnancy was established by 348 samples from healthy women with normal pregnancies. This was compared with the levels found in the presence of various fetal malformations--Rh-isoimmunization, maternal diabetes, chromosomal anomalies, and fetal death in utero. The findings and their implications are discussed.

Amniotic Fluid↗
PubMed1978

[Corneal covering of cornea in ulcerative keratitis: clinical and histological observations (author's transl)].

Clinical and histological findings are demonstrated in 4 cases with ulcerative keratitis treated by covering with full-thickness cornea. In only two cases the initial keratitis healed with scarring and a keratoplasty could be performed. The donor cornea is resorbed very slowly, remnants of Descemet-membrane of the graft are seen even after 20 months. Immunological reactions could not be observed.

Aged↗
PubMed1978

Further studies on liver glyoxalase I and glyoxalase II. Activity in mice bearing sarcoma 180 and L1210 leukemia.

Determinations were made of glyoxalase I and glyoxalase II acitivity in the liver of mice (BDF1 and DBA2 strains) bearing sarcoma 180 and L1210 leukemia in ascites form. A progressive decrease in the both glyoxalase I and glyoxalase II activities to about 40--60% of that of the control groups was observed within the developing period 8--9 days. Test results are interpreted in the light of the postulated role of this enzyme system in cell division and in the tumor development process.

Animals↗
PubMed1978

[The importance of regressive changes in the placenta during the so-called migration of the placenta (author's transl)].

Starting from the tenth to the sixteenth week of pregnancy ultrasonic placental localizations were performed in 22 pregnant women at four week intervals. In all cases the placenta was located in the anterior wall of the uterus and bordered or covered the internal os of the cervix. In 17 cases a cephalad migration of the placental localization was registered. In 5 cases the low implantation of the placenta did not change until delivery. In 14 of 19 cases marginal atrophic changes of the placenta were found. No morphologic abnormality was detected in five placentas from patients who showed migration of the placental localization. Since the placenta is tightly implanted in the endometrium a true migration of the placenta is unlikely. Our investigations show that areas of low implantation of the placenta are stretched with increasing growth of the uterus and then undergo regressive and pressure atrophy changes. It is likely that the cervical margin of the placenta cannot be detected by ultrasound in a large number of cases.

Atrophy↗
PubMed1978

[Results of the ciliary body exposure (CBE) in secondary angle closure glaucomas. 1. A clinical study (author's transl)].

The authors present their clinical results of the ciliary body exposure following Benedikt and Hiti. This technique has been performed in 23 patients suffering from secondary angle closure glaucoma. As far as the intraocular tension is concerned good results have been obtained in nearly half of the patients. The results are compared with those of other surgical techniques against secondary angle closure glaucomas.

Aged↗
PubMed1978

[Results of the ciliary body exposure (CBE) in secondary angle closure glaucomas. 2. A histological study (author's transl)].

After treatment of secondary angle closure glaucomas by ciliary body exposure with lamellar scleral resection five eyes had to be enucleated. In view of the histological findings taken from these eyes mode of action and therapeutic value of this operation are considered. The effectiveness of scleral resection seems to be doubtful and there is evidence that permanent regulation of intraocular tension depends mainly on direct diathermy of the ciliary body.

Ciliary Body↗
PubMed1977

Amino acids in the synaptic vesicle fraction from calf brain: content, uptake and metabolism.

A synaptic vesicle fraction was prepared from calf brain cortex, containing 10 identified amino acids and two unidentified ninhydrin-positive compounds, one of which is apparently a peptide. The most plentiful amino acids were taurine (1.8 nmol/g original tissue), glutamic acid (1.8), serine (0.9), aspartic acid (0.8) and GABA (0.8); the others identified were cysteic acid (or cysteinesulphinic acid), glutamine, alanine, glycine and lysine. The unknown peptide occurred in a high concentration (about 16 alanine equivalents/g), and contained mainly aspartic acid and serine. Cysteic acid (or cysteinesulphinic acid) also occurred in relatively high amounts, but its peak contained acid-labile impurities. The influx of [14C]glutamate into the vesicles took place by means of non-saturable migration, while two saturable systems having very similar properties were dominant only at low glutamate concentrations. Influx constants for these quantitatively low uptake systems were Km, 34 and 92 micrometer, and Vmax, 33 and 49 nmol/min/g obtained by v versus v/S plot. Almost the same values were also obtained by a 1/v versus 1/S plot. GAD and GABA-T activities in the vesicles were only 1/200th of those in the synaptosomes.

4-Aminobutyrate Transaminase↗
PubMed1977

[The monitoring of pregnancy in rhesus-sensitized women by a quantitative determination of bilirubin in amniotic fluid (author's transl)].

The prognostic accuracy of spectro photometric examination of the amniotic fluid and of a specific method for the determination of free bilirubin in the amniotic fluid are compared. Amniocentesis was carried out 166 times in 85 sensitized rhesus-negative pregnant women. Spectro photometric examination gave a misleading assessment in 28% of the cases. This applied particularly to Liley's Zone II, in which the presence or absence of haemolytic disease of the newborn was incorrectly predicted in up to 70% of the cases. By contrast, on evaluation of the cases using specific determination of free bilirubin, not a single value obtained after the 34th week of pregnancy led to false assessment of the fetal condition. There is a stong correlation between the extent of fetal damage and the bilirubin content of the amniotic fluid.

Amniotic Fluid↗
PubMed1977

A peptide containing aspartic acid, glutamic acid and serine in calf brain synaptic vesicles.

Free amino acids and other amino compounds in calf brain synaptic vesicles were identified and determined by thin-layer chromatography and ion-exchange chromatography. The vesicles contained ten identified amino acids with glutamic acid, aspartic acid, taurine and gamma-aminobutyric acid in the highest concentrations, and also cysteic acid (or cysteinesulfinic acid), glutamine, alanine, serine, glycine and lysine. The vesicles also contained certain unknown acid-labile, ninhydrin-positive compounds, one of which was a peptide yielding, after acid hydrolysis, about 40% aspartic acid, 30% serine, 15% glutamic acid, 10% glycine and possibly some alanine and lysine. The concentration of the peptide in the vesicles was as high as that of all the other amino compounds together.

Amino Acids↗
PubMed1977

[The follow-up of high risk pregnancies with the determination of estriol 16-glucuronid excretion. Second: Excretion in preeclampsia, post maturity, intrauterine growth retardation, diabetes, Rh incompatability and intrauterine fetal deaths (author's transl)].

The estriol 16-glucuronid excretion was determined in 186 urine samples in cases with preeclampsia, post maturity, pregnancies past the expected date of confinement, intra-uterine fetal deaths, congenital anomalies, Rhesus incompatability and diabetes mellitus. In groups with mild dystrophy, severe dystrophy, and intra-uterine fetal death, three zones of estriol 16-glucuronid excretion were determined. Zone 1 is suggestive of a possible fetal impairment. Zone 2 shows a high probability of fetal impairment and Zone 3 was considered as lethal zone suggestive of imminent intra-uterine fetal death. The degree of rhesus incompatability, disease of the fetus or of diabetogenic fetopathy was not recognizable by the estriol 16-glucuronid excretion.

Abnormalities, Multiple↗