Occupational doses in the Ontario Hydro nuclear power program.
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Biomedical subjects
Publications and source records attributed to R Wilson.
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A policy of limiting preoperative diagnostic imaging of pancreatic pseudocysts to barium studies, sonography, or computed tomography will result in failure to detect frequently associated lesions which may only be appreciated by arteriography and which radically alter both the prognosis and surgical approach. These associated lesions include: (1) pseudoaneurysms, probably the most common cause of major gastrointestinal hemorrhage in pseudocyst patients; (2) pancreatic carcinoma, a possible etiologic factor leading to formation of the pseudocyst; (3) benign or malignant cystadenomas which mimic pseudocysts clinically but can be usually identified arteriographically by prominant neovascularity; and (4) splenic vein obstruction which can produce extrahepatic portal hypertension and necessitate splenectomy. In our experience, these complicating lesions are relatively common. Their preoperative detection is desirable and is best accomplished by arteriography. For this reason, arteriography should be routinely performed in patients suspected of pancreatic pseudocyst.
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The abnormal pulmonary valve echocardiographic tracing in a patient with a double-chambered right ventricle is presented. Preoperatively, the posterior pulmonary valve leaflet demonstrated a partial closure in systole, followed by coarse fluttering of the leaflet. The postoperative echocardiographic tracing of the pulmonary valve was normal. It is suggested that an obstructive process proximal to either semilunar valve which converts laminar flow to turbulent flow is capable of producing a similar pattern in the leaflets during ventricular ejection.
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The abnormal prepartum ultrasonic scan in a case of fetal cystic lymphangioma is presented. A large intrauterine cystic mass adjacent to a 23-week-old fetus was identified by ultrasound. After delivery, this was proved to be a cystic lymphangioma extending from the fetal neck and supraclavicular region.
To establish the effect of local and remote myocardial ischemia on interventricular septal motion, 27 open-chest dogs were studied using ultrasound and radioactive microspheres. In 14 dogs the left anterior descending coronary artery was ligated. If the ultrasound beam traversed ischemic septum (proximal LAD occlusion), significant (P less than 0.05) declines in systolic septal velocity (26.4 +/- 2.9 to 6.4 +/- 1.8 mm/sec), and excursion (2.6 +/- 0.3 to 0.7 +/- 0.2 mm) occurred, and systolic thickening was reduced. Similar significant changes were seen when the ultrasound beam traversed nonischemic septum adjacent to the ischemic area (distal LAD occlusion). In 13 additional dogs, circumflex coronary ligation produced posterior ischemia. The mean septal velocity for this group increased significantly (21.8 +/- 2.6 to 26.5 +/- 3.3 mm/sec), as did the septal excursion (2.5 +/- 0.2 to 3.1 +/- 0.4 mm). We conclude that acute LAD occlusion causes a reduction in systolic velocity, excursion, and thickening of both the involved ischemic and the adjacent nonischemic septum. When myocardial ischemia was produced in a part of the ventricle remote from the septum, septal velocity and excursion increased.
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Peripheral blood lymphocytes obtained at 24-30 months after birth from a male with X-linked severe combined immune deficiency maintained in a gnotobiotic environment were characterized by T and B cell surface markers. A high proportion (55-80 percent) of circulating lymphocytes bore surface IgM as detected by direct immunofluorescence. A receptor for the activated C3 complement component was detected on 27-47 percent of his lymphocytes. Only 4-12 percent of the peripheral blood lymphocytes formed spontaneous rosettes with sheep erythrocytes (E-R). In general, no blastogenesis was detected in lymphocyte cultures stimulated with pokeweed mitogen or phytohemagglutinin although transient slightly positive responses to both mitogens were occasionally observed. Incubation of lymphocytes with bovine thymosin Fraction V did not increase the percentage of E-R nor induce lymphocyte blastogenesis in the presence of phytohemagglutinin.
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