Biomedical subjects
Publications and source records attributed to R Wenzel.
In order to study the genome organization of Mycoplasma pneumoniae a cosmid library of M. pneumoniae DNA was established using a newly designed cosmid vector (pcosRW2). From this library 32 overlapping clones were isolated covering a contiguous 720 kbp DNA segment representing about 90% of the genome assuming a genome size of about 800 kbp.
Two types of different repetitive DNA sequences called RepMP1 and RepMP2 were identified in the genome of Mycoplasma pneumoniae. The number of these repeated elements, their nucleotide sequence and their localization on a physical map of the M. pneumoniae genome were determined. The results show that RepMP1 appears at least 10 times and RepMP2 at least 8 times in the genome. The repeated elements are dispersed on the chromosome and, in three cases, linked to each other by a homologous DNA sequence of 400 bp. The elements themselves are 300 bp (for RepMP1) and 150 bp (for RepMP2) long showing a high degree of homology. One copy of RepMP2 is a translated part of the gene for the major cytadhesin protein P1 which is responsible for the adsorption of M. pneumoniae to its host cell.
The psychiatric adjustment centre is an important link in the treatment of chronic alcoholics. The adjustment centre attached to the County. Neurological Hospital at Lübben is used as an example to discuss the problems associated with sheltered work, living and recreation places. On the basis of four years of experience it can be said that some 10% of our patients with alcohol problems, most of whom have already broken links with their families and some of whom have already rejected society, require this form of treatment. Attention is drawn to the gradual transition from ward to outpatient treatment of patients with alcohol problems.
The problem of paranoiac development has been a subject of interest to psychopathologists since Jasper 's times. The clinical psychiatrist should still take pains to make a careful diagnosis of paranoiac developments and to prevent them from deteriorating into schizophrenia. The author presents a case study involving a querulous form of paranoiac development and discusses possibilities of counselling and treatment.
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In a study carried out in 413 alcohol patients, 135 case histories of male delirium patients were evaluated according to clinical-statistical factors. Of importance is the high rate of complications showing 35.9 per cent of delirium patients and a considerable recidivation rate with a remarkable share of second and third deliria. This indicates an excessive alcohol abuse in our service area over many years and makes it possible to draw conclusions with respect to an improvement of prevention, clinical treatment and after-care of the delirium patients.
Using a radiographic measuring technique, the authors determined the pulp-hard tissue ratio in 759 extracted, cariesfree, maxillary and mandibular teeth of exactly indicated ages. On the basis of the results obtained, recommendations are given for the depth of preparation of the various surfaces of the teeth as related to their ages. The suitability of various types of preparation for prosthetic abutments is discussed. For the preparation of the vestibular surface, the authors describe a modification of the grooving technique as yet recommended.
There has been a considerable increase since 1972 in the number of delirium alcoholicum patients admitted to our hospital. On the other hand, the number of chronic drinkers admitted for disaccustoming treatment has remained relatively constant during the past several years. The majority of patients are under 40. The relapse rate is rather high. The lethality rate is low in the case of treatment with clomethiazol. The purpose of this report is to incite workers at other clinics to analyze their respective patient stocks in order to discover supraregional causal factors, if any.
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