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Biomedical subjects

R Volpe

Publications and source records attributed to R Volpe.

At least 145 records · Page 8Linked to original sources
PubMed1983

Kaposi's sarcoma in lymph nodes concurrent with Hodgkin's disease.

The coexistence of Kaposi's sarcoma (KS) and Hodgkin's disease (HD) in the same lymph node is illustrated. The case concerns an 82-year-old Italian woman with a classic cutaneous KS who developed multiple lymphadenopathies. Involvement of a single node by KS and HD in the manner of a collision tumor was found unexpectedly. This very unusual finding might be regarded as more than coincidental because of the relatively frequent concurrence of diseases.

Aged↗
PubMed1983

Dermatofibrosarcoma protuberans metastatic to lymph nodes and showing a dominant histiocytic component.

Dermatofibrosarcoma protuberans is a neoplasm composed of cells that have morphologic characteristics of fibroblasts and histiocytes. We report the eighth documented case of dermatofibroma protuberans metastatic to regional lymph nodes. The metastases consisted predominantly of cells that appeared to be atypical histiocytes. This case is considered to be an example of dermatofibroma protuberans in which primitive histiocytic cells have not acquired secondarily acquired fibroblastic characteristics.

Adult↗
PubMed1983

A clinicopathologic review of 25 cases of chordoma (a pleomorphic and metastasizing neoplasm).

A clinicopathologic study of 25 cases of chordoma revealed that this tumor occurs principally in (68%), with a predominance for the sixth decade of life (seven patients--28%), and shows a predilection for the sacrococcygeal region (52%). The symptomatology was intimately related to the location of the tumor. Histologically, chordoma showed an extremely wide range in its cellular composition and pattern, not only from tumor to tumor, but also often in different portions of the same tumor. In addition to the large physaliferous cells in a lobular arrangement, large cells with apparently degenerating nuclei (ghost cells) were commonly seen; cells arranged in concentric spherical formations were observed in two cases, whereas small, round cells predominated in another case. A sarcomatous pattern was prominent in two cases. Large pink cells were frequently seen and in one case were arranged in epithelial-like columns. Whether these neoplastic components can be related to different degrees of tumor differentiation is difficult to establish. Histologic features of five cases in which metastasis occurred were compared to previously described metastasizing cases. These appear to be few reliable features helpful in suggesting the metastatic potential of this neoplasm.

Adolescent↗
PubMed1983

Aetiology of hyperthyroidism in Canada and Wales.

A retrospective, comparative review of 100 consecutive new outpatients presenting with hyperthyroidism in Cardiff, South Wales, and in Toronto, Canada, was performed. The aim was to quantify the causes of hyperthyroidism with particular emphasis on the prevalence of viral thyroiditis and "silent" thyroiditis. The proportional morbidity of Graves' disease (approximately 70%) was similar in the two groups. Toxic multinodular goitre and toxic adenoma (Plummers' disease) occurred significantly more frequently in Cardiff (25% v 8%), whereas thyroiditis predominated in Toronto (17% v 1%).

Adenoma↗
PubMed1982

Hemangioendothelioma (angiosarcoma) of bone: a distinct pathologic entity with an unpredictable course?

Eighteen cases of hemangioendothelioma (angiosarcoma) of the bone were found in a review of the files of the Department of Pathology of the Institut Curie. The ages of the patients, 11 males and seven females, ranged from 12--69 years (median 32 years). Pain was the usual symptom (11/16). Fifty percent (9/18) of the tumors occurred in the long tubular bones. Radiographic findings showed osteolytic, often multifocal, lesions without evidence of reactive bone formation. Grossly, the tumor masses were always found to be confined to the cavity of the bone. In all cases microscopic findings fulfilled the diagnostic criteria proposed by Stout. Solid and cellular small structures closely resembling embryonal vessels were observed in several instances, and were also helpful in identifying the endothelial vascular nature of the tumors. The histologic grade was difficult to determine in the majority of cases because there were several areas with different grades of differentiation. Of 15 patients with follow-up data, seven were alive and well with no evidence of disease 2--14 years after diagnosis (median nine years). Another patient was alive with metastatic disease after five years. The survival of the seven patients who died ranged from 7--53 months (median 21 months). This study confirms that hemangioendothelioma of the bone is a distinct pathologic entity. In contrast, it appears very difficult to determine the common clinical behavior of these tumors because they can show an extremely variable malignant potential.

Adolescent↗
PubMed1982

VM26 in malignant hematological diseases. A phase II study.

From August 1979 to April 1981, 33 consecutive patients with malignant hematological diseases, entered this phase II study. Sixteen patients had NHL, eight CLL, four Myeloma, three HD, one ALL, and one Polycythaemia vera. Two patients were unevaluable because of early death. The median age was 67 years. Eight patients were not pretreated with drugs. Two CR (5+, 20+ weeks) were obtained among NHL patients, whereas five PR were observed among two NHL, one CLL, one Myeloma, and one HD patients, respectively. Toxicity was almost exclusively hematologic and occurred in ten patients, in one of them causing severe myelosuppression. Moreover, severe asthenia, attributable to VM26, was encountered in three patients, in one requiring the suspension of the treatment.

Drug Evaluation↗
PubMed1982

[Morphologic features of tumor stage lesions of mycosis fungoïdes (author's transl)].

A morphological analysis was carried out on a series of five patients, with tumor stage lesions of mycosis fungoides. The histological findings of skin, lymph nodes, spleen, liver and bone marrow were investigated. Histologically the cutaneous infiltrate consisted of large cells (mycosis cells) and small atypical lymphoid cells (Lutzner cells). Among the large cells, which predominated in number, two principal types of cell could be distinguished: lymphoid cells comparable to the Lutzner cells because of their nuclear configuration, and poorly differentiated basophilic and pyroninophilic cells with irregular nucleus ("reticulum" cells?) or regular nucleus ("T-immunoblasts"?). Ultrastructural data of cutaneous lesion obtained for study from only one patient, were consistent with these findings. Lesions of lymph nodes and viscera consisted of a cellular composition which closely resembled that of cutaneous lesions. In particular, the large so-called mycosis cells were always found and represented a supportive histologic feature in identifying this disease.

Adult↗
PubMed1981

Adriamycin, bleomycin, vinblastine and DTIC in advanced diffuse lymphocytic poorly differentiated lymphoma.

From January 1975 to December 1979, 14 consecutive patients with advanced (stage III-IV) diffuse lymphocytic, poorly differentiated lymphoma (DLPD) were treated with adriamycin, bleomycin, vinblastine and DTIC (ABVD). Either maintenance combination chemotherapy with CVP or radiotherapy over bulky disease was added in the cases with complete response (CR). Fifty per cent of the patients achieved CR and 80% achieved objective responses. Among CRs, 100% were alive at 2 years, 70% of them without evidence of disease. Overall, 75% of the patients were alive at 2 years, 30% without evidence of disease. Toxicity was acceptable and no drug-related deaths occurred. ABVD is not the ideal combination for DLPD, but it should be taken into consideration in patients with advanced DLPD in which first line combination chemotherapy regimens are not successful.

Adult↗
PubMed1981

Hairy cells.

Explore the source record for details and available documents.

Aged↗
PubMed1981

Diagnosis and assessment of non-Hodgkin's malignant lymphomas of the larynx.

The present paper reports the clinicopathologic features of six cases of non-Hodgkin's lymphoma of the larynx observed during the last 14 years. After careful clinical staging only 3 patients had isolated laryngeal lymphoma (stage IE). Radiotherapy was administered as initial treatment in all cases. These patients are alive and well after 12, 6 and 1 years, respectively. Histologically, all laryngeal lymphomas of this study showed a diffuse pattern of growth. All lymphomas were of follicular center cell origin according to Lukes and Collins (29). Four cases were of low grade malignancy according to Lennert and Mohri (25), or grade I, according to the British (18) classification. The remaining two were of high grade malignancy or grade II. A careful histopathological diagnosis, which may separate other pathological conditions, and an appropriate staging, which may exclude dissemination of disease, are stressed as representing the basis for effective treatment. The applicability of current functional nomenclature is possible also in these extranodal lymphomas.

Aged↗
PubMed1981

Suppressor T-lymphocyte deficiency in Graves' disease and Hashimoto's thyroiditis.

The involvement of cell-mediated immunity in the pathogenesis of Graves' disease (GD) and Hashimoto's thyroiditis (HT) was investigated by employing a modified migration inhibition factor test using preparations of isolated T-lymphocytes. The migration of T-lymphocytes from patients with GD and HT in response to crude human thyroid antigen was significantly inhibited compared to the migration of T-lymphocytes from normal subjects. This response was organ specific. When normal T-lymphocytes were mixed with GD or HT T-lymphocytes in ratios varying from 1:9 to 1:1, the migration inhibition activity of the GD or HT T-lymphocytes in response to thyroid antigen was abolished, but was not abolished when two different GD or HT T-lymphocyte preparations were mixed. Mitomycin C inhibited this suppressive effect of normal T-lymphocytes in vitro, but did not influence the migration inhibition activity of the antigen-sensitized GD or HT T-lymphocytes. On the other hand, the migration inhibition of GD and HT T-lymphocytes was prevented by puromycin. There thus appears to be activity in normal T-lymphocytes which can suppress the ability of GD and HT T-lymphocytes to respond to the thyroid antigen, which is lacking in the GD and HT T-lymphocytes themselves. Our results are consistent with the hypothesis that there is a defect in suppressor T-lymphocyte function in GD and HT.

Adult↗
PubMed1980

Malignant histiocytosis in adults: report of 7 patients from Northeast Italy.

The clinical records and histologic material of seven adult male patients with malignant histiocytosis (MH), observed consecutively at our center during a four-year period, have been reviewed; four of these cases were seen in a year. All patients were born and lived within a radius of 30 miles from Pordenone, a town in northeast Italy. The diagnosis of MH was made in all cases on lymph node biopsy on the basis of the established histologic criteria [1]. At presentation, abnormal histiomonocytic cells were found in the bone marrow and peripheral blood of four patients, two of whom also showed cerebrospinal fluid involvement with atypical histiocytes at a relatively early stage of the disease. Staging procedures documented extensive disease in lymphatic, as well as in extralymphatic, sites in four patients; in three patients, the disease was confined to the lymphatic system. Combination chemotherapy was the first treatment employed in all cases. Four patients, three of whom had limited disease, achieved complete remission with quadruple combination chemotherapy (ABVD, CHOP, or MOPP); three patients with extensive disease achieved only partial remission of short duration with HOP. These results further support the view that adult MH is not obligatorily and rapidly fatal. Good responses to treatment with combination chemotherapy are possible, particularly in patients with disease limited to only lymphatic sites.

Adult↗