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Biomedical subjects

R Voigt

Publications and source records attributed to R Voigt.

At least 109 records · Page 6Linked to original sources
PubMed1986

[Testing of drug release from film pellets with special consideration of the thickness of the polymer coating].

The influence of the thickness of polymer films on drug release was studied by means of an apparatus, developed especially for the examination of film-coated pellets. To show the direct dependence of the thickness of the polymer layer on the process of liberation a sequence of ten coating steps was chosen. On the contrary the release of active ingredients of varying dissolution behaviour was synchronous and didn't depend on the pH-value of the medium. The results show, that by using the proper coating material the thickness of the layer can be used to control the drug liberation process. The comparison of the release from different coating steps in the apparatus described makes it possible to produce mixtures of pellets with both a quick onset and a long duration of action by using only one type of coating material.

Caffeine↗
PubMed1986

[Radiation-induced changes in the properties of gelatin].

The impact of high energetic rays between 10 and 100 kGy on gels and solutions of gelatin is studied. Physical and biopharmaceutical properties are changing dependent on the rayage and the content of glycerol and water. The possibilities of influencing melting behaviour, viscosity, rigidity, temperature of gel formation, imbibition behaviour and dissolution in foillike preparations are determined. Glycerol is able to compensate the radioinduced changes of the structure of gelatin up to a dose of 50 kGy. Its use as a radioprotective material is being discussed.

Adsorption↗
PubMed1986

[Availability of propylphenazone from suppositories. 2. Bioavailability].

The examination of the bioavailability from 4 different preparations of propyphenazone suppositories on a fatty base, studied in 10 healthy volunteers, showed bioequivalence as was judged by means of the AUC-values. Aminophenazone suppositories of an equivalent dosage led to significant higher values of plasma concentrations if compared with propyphenazone. The in vivo findings correlate with in vitro results of availability.

Adult↗
PubMed1986

[Personal experiences with conservative drug therapy of urgency symptoms in the female].

On the basis of clinical and urodynamic results the authors adopt a definite attitude to the treatment of the urgency syndrome in the woman with the anticholinergic drug propiverin hydrochloride (Mictonorm). The results show a satisfactory improvement in 42 of 68 women (= 62%), whereas 24 of 68 women (= 35%) reported a subjective improvement of the clinical symptoms. These results correspond with the data from literature. In 15 women with no satisfactory effect the beta 2-sympathicomimetic drug clenbuterol (Contraspasmin) was additionally applied. There was a satisfactory success under this medication in 11 of the 15 women (= 72%). The results are discussed with the references of the literature to the conservative therapy of the urgency syndrome.

Benzilates↗
PubMed1986

[Personal experiences with bladder training in the treatment of urge incontinence in the female].

Anamnestic and urodynamical results are evaluated before and after bladder retraining drill (BRD) in women suffering from urge incontinence. A continence rate of 74% was determined 6 to 24 months after BRD. This agrees with dates reported by literature. Urodynamically we obtained an improvement of cystometric parameters (even in parts statistically significant). The values of the urethrocystographic angles and the urinary flow rate have been not changed. We could state that the BRD is a good possibility to realize multistep-therapy of female incontinence.

Female↗
PubMed1986

[Urodynamic and roentgenologic findings before and following complex physical therapy of urinary incontinence in the female].

In 42 patients complaints following therapy have been correlated to the pretherapeutic urodynamic findings and in 58 patients pre- and posttherapeutic urometric and X-ray findings have been compared independent from subjective result in oder to have objective parameters for the effectivity of conservative treatment of urinary incontinence. The best results could be achieved, if in the starting urometry the pressure transmission was bad and the dosing pressure of the urethra in rest adequate to the age. In analogy about identic urethral closing pressure in rest, but significant increase of the functional urethral length and a better pressure transmission in a sitting position could be found. Good results of conservative treatment on urge incontinence symptomatology could be derived from increasing bladder capacity and compliance. Against it a posttherapeutic increase of urinary incontinence signs by training-effects of exercise therapy has to be stated in the comparison of X-rays. Altogether the high rate of 63 per cent curing and 20 per cent improvement could not be detached sufficiently by urometric and radiography findings. This discrepancy has been discussed.

Female↗
PubMed1986

[Changes in the parameters of the urethral pressure profile by measuring the patient in supine and sitting position].

For testing the influence of the examination position on the parameters of the urethrocystometry 124 findings of urethrocystometry of 103 female patients were evaluated in 3 groups. In these cases slight alterations develop when changing between lying and sitting position, whereby in sitting position a greater differentiation of an existing component of stress incontinence becomes possible. On the basis of our examination findings and the references in literature it seems to be advisable to perform the urethrocystometry in the same session both in lying and in sitting position for further improvement of the indication for therapy.

Female↗
PubMed1985

[Urodynamic results before and after physiotherapy of women with stress incontinence].

With reference to the urodynamic results in 21 women with mild stress incontinence who underwent conservative treatment with pelvic floor exercises over a period of three to six months prior to possible surgery, the author comments on the value of this therapy. At the time of follow-up examination 11 of the women were so satisfied with the regression of their complaints that surgery was unnecessary. Only two patients reported no change in their symptoms after treatment. It may be possible to use the parameters of urethrocystometry as an objective criterion of success; however, these are not statistically significant; they merely indicate a tendency to improvement. The results are discussed together with information given in the literature.

Adult↗
PubMed1985

[Results and experience with urethrocystography in diagnosing female stress incontinence].

The normal parameters of urethrocystography were evaluated in 324 examinations. There were definite differences between continent and pressure-incontinent women on the one hand, and stress-incontinent patients on the other, as regards the pubo-urethral angle, but not as regards the posterior vesico-urethral angle. Preoperative and post-operative urethro-cystograms showed statistically significant differences.

Adult↗
PubMed1985

Pharmacokinetic studies of azlocillin and piperacillin during late pregnancy.

In this paper pharmacokinetic data of acylureidopenicillins (azlocillin and piperacillin) in pregnant women in the last trimenon are compared with those from nonpregnant controls. Four g of each drug was administered as slow bolus injection intravenously. The concentrations in serum and urine of both drugs were determined by polarographic and microbiological methods, for comparison. We used for evaluation of pharmacokinetic data a computer program based on the equations of a two-compartment open pharmacokinetic model. Our investigations show that there are not any different pharmacokinetic values of both antibiotics between pregnant women and healthy nonpregnant volunteers. We can state that both antibiotics are well determined by both analyzing methods which give us identical pharmacokinetic results.

Adult↗
PubMed1985

[Pulse polarographic determination of piperacillin (Pipril) in serum and urine].

Two pulse polarographical methods for determination of the half-synthetic penicillin derivate piperacillin in serum and in urine are described. 3.7 X 10(-5) mol/l (20 micrograms/ml) can yet been proved in serum with the direct pulse polarographical determination. 1.85 X 10(-6) mol/l (1 microgram/ml) can quantitatively be determined after preceded hydrolysis. Both the methods are diffusion standards being well developed which can be evaluated in an adequate manner. The piperacillin concentrations determined by pulse polarography agree to the levels of the agar diffusion test. The precision is some reduced by the separations incorporated. Inspite of the hydrolysis, the pulse polarographical method of determination will offer more prompt and reliable results.

Chromatography, Thin Layer↗