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Biomedical subjects

R Tsuchiya

Publications and source records attributed to R Tsuchiya.

At least 217 records · Page 12Linked to original sources
PubMed1977

Congenital cystic dilation of the bile duct associated with Laurence-Moon-Biedl-Bardet syndrome.

We describe a 26-year-old man in whom the Laurence-Moon-Biedl-Bardet syndrome had been associated with congenital cystic dilations of both the intrahepatic and extrahepatic biliary tract. The fact of the simultaneous occurence of two rare diseases in a single patient suggests the congenital origin of cystic dilation of the biliary tract and the importance of examining for a possible association of anomalies in the alimentary tract with the Laurence-Moon-Biedl-Bardet syndrome.

Adult↗
PubMed1977

Ultrastructure of botryoid sarcoma of the common bile duct.

A case of botryoid sarcoma of the common bile duct in a 4-year-old girl was reported. Electron microscopic examination disclosed that the neoplasm consisted of three types of cells: polygonal, elongated, and small cells. The former two contained moderate to large amounts of poorly developed myofibriles in the cytoplasm with occasional A, I and Z-bands. The small cells contained mitochondria and dilated rough endoplasmic reticulum but few myofilaments. Deposits of glycogen granules were constant components of the neoplastic cells. Mitosis was striking in the small cells. Abnormal multilaminar endoplasmic reticulum was observed in the small cells in the mitotic stage.

Bile Duct Neoplasms↗
PubMed1977

Malignant tumors in choledochal cysts.

Between 1960 and 1975, 17 patients with congenital cystic dilatation of the common bile duct (choledochal cyst) were treated and three were associated with malignant tumors in the cysts and one was with carcinoma of the gallbladder. Preoperative diagnosis of adenocarcinoma in the choledochal cyst was established in one patient by cytologic examination of the bile which was obtained during the procedure of endoscopic pancreaticocholangraphy (EPCG) and percutaneous transhepatic cholangiography (PTC). Definitive treatment of the choledochal cysts associated with malignant tumors in the biliary tract was accomplished by excision of the cysts with tumor and choledochojejunostomy in two patients, by cystoduodenostomy following external drainage in one and by cholecystectomy with resection of invaded transverse colon in one with cancer of the gallbladder. Successful excision of choledochal cysts in 11 patients including three cases associated with malignant tumors in the biliary tract during the last 15 year period is the basis of this report.

Adenocarcinoma↗
PubMed1977

Endoscopic aspiration biopsy of the pancreas.

Preoperative endoscopic aspiration biopsies were performed on 51 patients with pancreatic lesions using either a duodenal or gastric fiberscope and a newly designed biopsy needle. The accuracy of this method in the diagnosis of carcinoma of the pancreas was 84.0%. Although there were three false-negative diagnoses, there were no false-positives. No complications that could be attributed to this procedure were encountered.

Adenocarcinoma↗
PubMed1976

Ultrastructural studies of experimental acute pancreatitis.

Acute pancreatitis was studied by electron microscopy after retrograde infusion of either trypsin, and/or beta-glucuronidase into the canine pancreatic duct. Marked changes were induced by the mixture of trypsin and beta-glucuronidase. (1) The acinar cells were initially excavated from the acinar lumen and formed cystic bodies in themselves. The cystic bodies were then disrupted at their marginal membranes, and the acinar cells were filled with a large amount of fibrillar materials which originated from the contents of the cystic bodies. At this time, the luminal margin of the acinar cells completely disappeared. (2) The cellular organellas and the intracellular fibrillar materials in the acinar cells were discharged into the interstitial space through the disrupted basal lamina. Infection in the pancreatic ductal system was considered to play an important role in the pathogenesis of acute hemorrhagic pancreatitis.

Acute Disease↗
PubMed1976

Sarcoma botryoides arising from the biliary tract of children. A case report with review of the literature.

Sarcoma botryoides (embryonal rhabdomyosarcoma) originating from the common bile duct is reported in a 4-year-old girl. Grossly, the tumor is characterized by multiple polypoid and grape-like projections into the lumen of the common bile duct and shows plate-like thickening of the common bile duct wall. On multiple cut-sections these polypoid masses are soft and light yellow white except for multifocal hemorrhage. Histologically the tumor consists of undifferentiated mesenchymal cells with a myxomatous appearance; rhabdomyoblasts with varing degree of maturation are scattered here and there within the matrix. These cells are characterized by a strap and racket shape with abundant eosinophilic cytoplasm and elongated cytoplasm with cross striations. The histogenesis of the tumor may be related possibly to an abnormal differentiation of the primitive mesenchymal cells toward striated muscle cells.

Bile Duct Neoplasms↗
PubMed1975

Portal hypertension due to hepatic artery-portal vein arteriovenous fistula--a case report.

A case of portal hypertension secondary to traumatic hepatoportal arteriovenous fistula with portal fibrosis was successfully treated by ligation of the afferent hepatic arteries which decreased significantly portal pressure and corrected the abnormal blood inflow to the portal vein via A-V fistula resulting in a recovery of the disturbed liver function. Collateral blood supply from the left hepatic artery into the right hepatic lobe was found to be quite satisfactory after the ligation of the hepatic artery. Hemodynamic data and clinical findings of the present case suggest that the mechanism responsible for the portal hypertension is the inflow block resulting from the interruption of portal venous flow by the inflow of arterial blood via A-V fistula and the subsequent increased blood pressure in portal vein radicals.

Adult↗