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Biomedical subjects

R Trazzi

Publications and source records attributed to R Trazzi.

At least 55 records · Page 3Linked to original sources
PubMedDate not supplied

Propofol 1% and propofol 2% are equally effective and well tolerated during anaesthesia of patients undergoing elective craniotomy for neurosurgical procedures.

BACKGROUND: The 2% formulation of the intravenous anaesthetic agent, propofol (Diprivan), delivers half the amount of lipid compared with the original 1% formulation. This may provide an acceptable alternative for patients who have an impaired ability to metabolise lipids. METHODS: This study was a multicentre, randomised, open comparison of parallel groups. Seventy-three adult patients undergoing elective craniotomy in neurosurgery were randomised to receive either propofol 1% (10 mg/ml) or propofol 2% (20 mg/ml) for induction and maintenance of anaesthesia. RESULTS: Analysis of induction time (199 s, 1%; 202 s, 2%; p > 0.05) and induction dose (1.13 mg/kg, 1.12 mg/kg; p > 0.05) shows that propofol 1% and propofol 2% are pharmacodynamically equivalent. Both formulations were similar regarding overall administration rates, recovery times, haemodynamic variables and tolerability. Plasma triglyceride levels, were lower in the propofol 2% group compared with the propofol 1% group, and significantly lower (p < 0.05) from 1 to 4 hours after induction. CONCLUSIONS: We conclude that propofol 2% is as effective and as well-tolerated as propofol 1% for anaesthesia and is an acceptable alternative to propofol 1% in patients undergoing elective craniotomy in neurosurgery. The lower lipid load suggests it may be of particular benefit to patients with disorders of lipid metabolism.

Adult↗
PubMedDate not supplied

Pharmacologic and surgical procedures for prevention of the revascularization syndrome.

Combined pharmacologic and surgical criteria are evaluated for prevention of the metabolic changes which characterize the revascularization syndrome (r.s.). The procedures basically consist, prior to restore the arterial circulation, in a regional arterial wash-out using a solution which is pumped, either manually or by means of a peristaltic pump, in the vascular bed of the devscularized territory; the washing solution is then collected through a flebotomy conducted on the regional venous drainage and prevented from entering the blood stream.

Acidosis↗