Toxicological and pharmacokinetic studies on phenaglycodol in rats. GLC assay for its determination in plasma.
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Biomedical subjects
Publications and source records attributed to R Testa.
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A functional study was made of 40 patients with bioptically diagnosed CPH. Fractional BSF clearance was the most frequently altered test and its correlation with the anatomical damage was significant. In particular, the fractional uptake clearance (K1) gave a pointer to both the presence of liver damage and its type. Elimination clearance (K2) may also be useful, especially in the differentiation of histological pictures on the borderline between CAH and CPH. In the evaluation of CPH, therefore, BSF clearance is of marked assistance both in rounding out the histological diagnosis, and in cutting down the need for control biopsies.
The urinary excretion data after I.M. administration of water soluble lysine salt of Alclofenac were analysed by the techniques suggested by Niebergall, Wagner, Martin and Cummings. All methods used give similar estimates of both DU infinity and Kel with exception of the "Sigma minus" method when DU infinity obtained by "Rate Method" was utilized. Niebergall's method is preferred on the basis that it provides an accurate estimation of both DU infinity and Kel. These parameters, evaluated after administration of Alclofenac-lysinate, resulted in agreement with previously reported data obtained after administration of different pharmaceuticals of acidic drug.
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