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Biomedical subjects

R Testa

Publications and source records attributed to R Testa.

At least 199 records · Page 11Linked to original sources
PubMed1981

[Hourly distribution of episodes of angina at rest. Effect of medical treatment].

Aim of the study was to evaluate whether frequency of myocardial ischemic attacks at rest (IA) had any identifiable distribution during 24-hour periods. Two ECG leads were continuously recorded by an Oxford 4-24 tape recorder for a total of 148 days in 10 patients admitted to CCU because of frequent spontaneous anginal attacks. During 48 days, in absence of therapy, 682 IA were recorded (2.03 per patient per day). They showed a symmetrical bell-shaped distribution curve in the 24 hour periods with a peak occurring at 5 a.m. and 43% of IA from 0 to 6 a.m. Only 25% of IA was symptomatic with the lowest values (10%) between 2 and 6 a.m. Distribution of IA was independent from their distinctive electrocardiographic feature [ST (71%) or T changes]. During 100 days with therapy [Verapamil and/or Isosorbide dinitrate ointment) a marked reduction of episodes was observed (0.64 per patient per day), while their distribution, the incidence of different electrocardiographic patterns and percentage of symptomatic IA remained unchanged. Attenuated incidence, but inalterated distribution of IA with therapy suggest its possible effect on the threshold response of coronary smooth muscle to vasoconstrictor stimuli rather than its primary effect on pathogenetic factors.

Adult↗
PubMed1981

[Intermittent claudication: topical treatment with isosorbide dinitrate ointment. Preliminary results].

Following the casual observation reported by one anginal patient of ours, of improvement of its claudicatio intermittens with application of isosorbide dinitrate ointment directly on the leg suffering pain, we undertook a study to assess the possible use of the drug in peripheral vascular disease in a group of 10 patients suffering of a severe form of claudicatio intermittens. The effect of the drug was tested 1) by the subjective valuation of the patient itself 2) by treadmill stress tests performed at constant rate. In this case were used as reference parameters the distance walked without any symptoms and the maximal distance reached by each patient. The treadmill stress test was performed in basal condition and after longterm administration of isosorbide dinitrate ointment 100 mg three times a day for 30-45 days. In 5 patients the control test was repeated twice in different days to evaluate the reproducibility of the measure that resulted good, while other 5 patients performed the test one hour following the application of the drug in order to assess a possible acute effect of the drug that was not present in any patient. All the patients noted an improvement in their walking capacity but only after 15-20 days of treatment. In basal condition the distance walked without any symptoms by the patients was on the average m. 51 (+/- 52) and the maximal distance reached was m. 143 (+/- 111), while after the treatment were m. 151 (+/- 136) and m. 384 (+/- 203) with a difference highly significative (p less than 0.05 and p less than 0.01 respectively). From our data although preliminary, it is apparent that longterm local application of isosorbide dinitrate is effective in the treatment of patients with peripheral vascular disease and that the action of the drug seems to be related to a local effect.

Administration, Topical↗
PubMed1980

[Hepatotoxicity of cyclophosphamide in the rat after prolonged treatment: a histomorphological study].

The AA. have examined the toxic effects in rats liver caused by cyclophosphamide (12 mg/kg) chronic administration for 12 months. The toxicity for the liver is moderate and the lesions are not specific. The lesion are various histologic changes, lymphomonocytic infiltration of the peri-portal space, periportal fibrosis and interstitial haemorrhages. Similar lesions with lesser recurrence are also in not treated rats.

Animals↗
PubMed1980

[Histopathological studies of the rat pancreas after prolonged treatment with imuran. Preliminary findings].

The AA. have studied the pathological effects on the pancreas of rats after chronic administration of azathioprine (AZA) in different doses. The most significant lesions are flattening of duct epitelium and the presence of protein plugs in the ducts. These pancreatic lesions are significantly more frequent in rate treated with higher doses than in controls and so are dose-dependent.

Animals↗
PubMed1980

[The behaviour of gamma-glutamyltranspeptidase in the diagnosis of secondary hepatic malignancy: its relationship to other serum enzymes (author's transl)].

In order to determine the value of serum Gamma-glutamyltranspeptidase in the diagnosis of secondary hepatic malignancy, the variations of the serum measurement of different hepatic enzymes have been studied in 160 patients, 80 of which have hepatic metastases gamma GT showed an increase in 95% of the patients with metastases even if there has been a high percentage of false-positive results in the control patients and in those who were carriers of cancer without hepatic metastases. The Authors, after having briefly discussed the meaning of the false positivity rate, conclude that such an enzyme proves once to be a simple and sensitive test of secondary hepatic malignancy and that further studies will help to make it more specific.

Adult↗
PubMed1980

[Low reliability of ECG monitoring in CCU for detection of ischemic episodes (author's transl)].

In 10 patients with frequent anginal attacks admitted to CCU, 2-lead ECG Holter monitoring (H-M) was performed for a total of 10 days. The number of ischemic episodes detected by retrospective analysis of H-M was compared with the number detected on the basis of symptoms and continuous visual ECG monitoring in CCU (CCU-M) by highly trained staff. A total of 157 episodes was identified by H-M [82 ST elevation (ST), 15 ST depression (ST) and 60 t wave changes]. Only 15 of these episodes were detected by CCU-M (13 ST, 1 ST and 1 T wave changes) of which 12 were symptomatic. When 6 H-M ECGs were simultaneously displayed on an oscilloscope in real-time (as in CCU-M), one of the Authors was able to detect only 36% of the episodes, whereas the frequency reached 80% when the analysis was limited to one tape at the time. The results show the low reliability of the CCU-M in detecting ischemic attacks; this appears mainly related to the display of multiple tracings.

Angina Pectoris↗
PubMed1980

Morphologic evolution of CAH with and without therapy. A two year follow-up.

The morphologic evolution of chronic active hepatitis (CAH) over a two-year period in 57 post-puberty patients with homogeneous characteristics was studied retrospectively. Of these, 29 received therapy with steroids and immunosuppressive drugs while 28 received no therapy. At the end of the 2-year period, the statistically assessed morphologic results showed that the therapy had had a positive effect on the initial morphologic pattern.

Adult↗