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Biomedical subjects

R Terinde

Publications and source records attributed to R Terinde.

86 records · Page 5Linked to original sources
PubMed1976

[Karyotype-phenotype correlation in a 46,Xdel(X) (p22) diagnosis (author's transl)].

In a patient with a height of 1.46 m, short neck and cubitus valgus the unbalanced karyotype 46,Xdel(X)(p22) was found. The mother of the proband has the balanced karyotype 46,Xt(X;15)(p22;p1). The mother is 1.56 m tall and has a short neck and cubitus valgus too. For this reason the deletion of the Xp22 band seems to cause the short stature of Turner patients. Our proband has had 2 pregnancies which ended as abortions in the 2nd and 4th month. As Giraud et al. (1974) have shown the deletion of the dark middle bande of the short X chromosome arm induces a slight dysgenesie of the gonade.

Abortion, Spontaneous↗
PubMed1976

[Prenatal detection of genetic disorders by ultrasonically guided amniocentesis in twin pregnancy (author's transl)].

In contrast to former opinions detection of genetic disorders in early multiple pregnancy is possible by advanced techniques of amniocentesis Prenatal diagnosis has been performed in a twin pregnancy of an 41 years old patient by two ultrasonically guided amniocenteses. Injection of Indigo carmin after the first puncture showed two separate amnion cavities. Postpartal findings proved prenatal diagnosis.

Amniocentesis↗
PubMedDate not supplied

[Interobserver reproducibility of Doppler ultrasound measurements of the fetal ductus arteriosus].

In a subgroup of 418 Doppler flow velocimetries of the fetal ductus arteriosus, which were performed to evaluate possible effects of low dose aspirin on fetal hemodynamics, an interobserver reproducibility study was carried out. 55 pulsed Doppler measurements of the fetal ductus arteriosus were performed within 24 hours by two different examinators. Pulsatility Index (PI), peak velocity (Vmax), mean velocity (Vmean) and enddiastolic velocity (Vmin) were obtained from the flow velocity profiles and correlation and variability coefficients were calculated. Peak velocity has been shown to be the most reproducible parameter with highest correlation and lowest variability.

Anti-Inflammatory Agents, Non-Steroidal↗
PubMedDate not supplied

[Utero- and fetoplacental hemodynamic measurements with low dose aspirin].

A prospective randomized double-blind study of low-dose aspirin treatment (100 mg/d) was conducted on a population of 43 pregnant women at risk of pregnancy-induced hypertension, preeclampsia, intrauterine growth retardation. Doppler ultrasound blood flow measurements of the uterine arteries and the umbilical cord, at the fetal and placental end, were obtained on a two-weekly interval in between 18 to 40 weeks of gestation. During the course of pregnancy Doppler indices of both vessels decreased, whereas the absolute velocity of the uterine arteries increased. Perfusion of both vessels did not show any relevant differences in between the aspirin- and placebo-group. Both groups showed a similar median duration of gestation at time of delivery (278 d aspirin vs. 270 d placebo). Comparison of median birthweight (3152.5 g aspirin vs. 2900 g placebo) did not show any significant difference. There were no haemodynamic effects of low-dose aspirin on the utero- and fetoplacental circulation to be demonstrated.

Anti-Inflammatory Agents, Non-Steroidal↗
PubMedDate not supplied

[Comparison of the rate of complications after primary, secondary and emergency Cesarean section].

3799 women delivered by cesarean section at the Department of Obstetrics and Gynaecology of the University of Ulm between 1978 and 1988 were retrospectively divided into three groups, according to the urgency of cesarean section: group [1]: elective cesarean section (n = 1333), group [2]: urgent cesarean section (n = 2295), group [3]: emergency cesarean section (n = 171). Group [1] comprised the greatest risk in terms of maternal diseases, pregnancy complications and previous cesarean sections, group [2] the least. Intraoperative complications were seen more often in group [3] than in groups [1] and [2] and included a greater number of operations lasting more than 2 hours (group [3]: 2.3%, group [1] and [2]: < or = 0.5%), a higher incidence of severe blood loss and consequent need for blood transfusions, and of serious complications such as damage to adjacent organs and need for hysterectomy (group [3] 4.7%, groups [1] and [2]: 1.6%). In group [3] the rate of postoperative complications, especially of infections, was unexpectedly low (e.g. fever > 38 degrees C in group [1]: 8.6%, group [2]: 11.5%, and in group [3]: 9.9%). This was not only explainable by more frequent prophylactic use, in group [3], of antibiotics whose efficacy in reducing infections was demonstrated. Altogether five patients died, two deaths, both in group [2], were directly related to cesarean section. Between 1978 and 1988 an increasing incidence of low birth weight infants was found in all groups, with the highest rate in group [3].(ABSTRACT TRUNCATED AT 250 WORDS)

Adult↗
PubMedDate not supplied

[Prenatal serum screening for Down's syndrome].

With the aid of two commercially available analysis programmes we effected non-invasive assessment of the risk for Down's syndrome in 597 pregnancies with healthy fetuses and in 22 pregnancies with trisomie 21-affected fetuses, maternal age ranging between 18 and 45 years. Based on the women's serum levels, hormone concentrations of AFP, free estriol and beta HCG were determined, a multiple of their median was combined with the age factor, and the result used as a parameter for overall risk estimation. A risk cut-off-level greater then 1:250 was considered to represent a positive risk. For patients younger than 35 years test sensitivity, at just over 50%, was found to be low. For those aged 35 years or greater, however, the Dermalog programme was able to detect 94.4% and the Alpha programme 88.2% of fetuses affected by trisomy 21, with a false-positive rate of 19.6 and 19.1%, respectively. If the test were to be applied to all pregnant women beyond 35 years of age the detection rate of Down's syndrome could be nearly doubled compared to today's figure (only 50%, of women in this age group undergo amniocentesis). By the same token the rate of amniocentesis-induced abortion (approx. 1%) could be reduced to about one third.

Adult↗
PubMedDate not supplied

[Reproducibility of continuous wave Doppler studies in pregnancy].

The inter- and intraobserver variability of Doppler flow velocimetries of uterine, arcuate and umbilical arteries was studied using a 4 MHz continuous wave system in the second and third trimester of pregnancy. There was no significant variation in indices used to characterize the maximum frequency outline of waveforms of uteroplacental and umbilical arteries neither when two observers examined the same patient nor the examination was performed several times on the same day or over a 24 hour period by the same observer. In uteroplacental and umbilical arteries continuous wave measurements are highly accurate and are not inferior to the more expensive pulsed Duplex systems.

Blood Flow Velocity↗
PubMedDate not supplied

[Analysis of the serum concentration of pregnancy protein-1 (SP-1) offers no advantage in comparison with menstrual anamnesis and ultrasound biometry in determining gestational age].

In 69 patients with normal pregnancy the estimated day of confinement (EDC) was determined by three different methods (last menstrual period = LMP, ultrasound, and determination of Schwangerschaftsprotein-1 (SP-1) serum concentration). Ultrasound and LMP were shown to predict the EDC with approximately the same accuracy. While data obtained by LMP were scattered a little bit more around the mean value, data obtained by ultrasound tended to underestimate the EDC slightly. Determination of SP-1 serum concentration had the lowest predictive value in assessing the EDC. Accordingly, we don't consider routine SP-1 determinations to be a useful test in antenatal care.

Female↗
PubMedDate not supplied

[Prenatal diagnosis of disorders of fetal kidney function--a critical analysis of 95 cases].

Ninety-five gravidae were examined at Düsseldorf University Gynecological Clinic for assessment of the fetal renal system. Suspected disorders were ruled out in 33 cases by sonography. Urogenital malformations without major loss of function were diagnosed in 25 fetuses. The prognosis was unfavorable in 15, and 22 fetuses had other disorders. In 5 out of 22 infants on whom autopsy was performed, the kidneys were found to be normally developed, contrary to the sonographic diagnosis. However, all five of these infants had anomalies of the umbilical artery. It is well known that cases of anhydramnios in the first half of pregnancy have a poor prognosis. In order to assess such cases better, the authors consider the following examination procedure appropriate: 1) filling with amniotic fluid; 2) Lasix provocation test; 3) thorough sonographic examination of the fetus; 4) karyotyping; and 5) identification of maternal infections. It is at present impossible to say whether there is a statistical relationship between changes in the umbilical cord and disorders of renal function.

Amniotic Fluid↗
PubMedDate not supplied

[Growth of fetal extremities, estimation of gestational age and prenatal diagnosis of malformations by measurement of fetal limb bones by ultrasound in the second trimester].

Fetal extremities were examined in 300 pregnant women between 16th and 24th week of gestation by real-time ultrasound. The limb bones of femur, humerus, tibia-fibula and radius-ulna complexes were measured and correlated to menstrual age and estimated age by ultrasound. The standard curves for limb bone growth show a linear increase with constant standard deviations. As fetal limb bone growth is close correlated to gestational age estimation of gestational age is exact as estimation from menstrual dates. Finding out skeletal malformations can be done very effective in patients of high risk.

Congenital Abnormalities↗
PubMedDate not supplied

[Blood screening for Down's syndrome in women under 35 years of age with an age-independent index].

The need for alternatives to amniocentesis, beset by 1% abortion rate, has been increasingly voiced over the past years and also includes the under 35 age group. However, the known age-dependent screening programs such as Alpha program according to Wald (1988) and the Dermalog Program according to Norgaard-Pederson (1990) only yield a detection rate of 50 or, at best, 70% (Müller, 1992) for this age group. We tried to improve this result by index calculation. Compared to the tested age-dependent screening programs the Ulm Index achieves a 25 to 40% higher detection rate (85%). For pregnant women beyond 35 years the detection rate of Down's syndrome can even be raised to 95-100% by a combination of the Alpha or Dermalog program with the Ulm Index, without entailling an increase in the rate of false-positive results.

Adult↗