Search PubMed⌕ Search

Biomedical subjects

R Sundmacher

Publications and source records attributed to R Sundmacher.

At least 163 records · Page 9Linked to original sources
PubMed1987

The potency of interferon-alpha 2 and interferon-gamma in a combination therapy of dendritic keratitis. A controlled clinical study.

Forty-five patients with virologically confirmed dendritic keratitis were treated in a randomized, double-blind controlled study with a basic therapy of trifluorothymidine (TFT) eye drops. In addition they received different human recombinant interferon (rHu IFN) eye drops. The following results were obtained for average healing times: TFT plus one drop daily of rHu IFN-alpha 2 arg (30 million iu/ml): 3.3 days, TFT plus rHu IFN-gamma (30 million iu/ml): 3.9 days, TFT plus a mixture of alpha plus gamma (0.3 million iu/ml each): 6.1 days, TFT plus a mixture of alpha plus gamma (1.5 million iu/ml each): 3.3 days. High-titer gamma interferon did not significantly differ from high-titer alpha interferon in the combination therapy of dendritic keratitis. A mixture of alpha plus gamma at a moderate titer (1.5 million iu/ml each) was as effective as a high-titer mono-preparation. Adding a low-titer interferon mixture gave no better therapeutic results than antiviral monotherapy. Thus it seems possible to save about 90% of interferon commonly used in the combination therapy of dendritic keratitis by applying a mixture of different suitable interferons instead of interferon monospecies.

Clinical Trials as Topic↗
PubMed1986

[Dendritic keratitis following corneal foreign body].

Traumatogenic herpetic eye disease may be initiated via several pathophysiologic pathways. Trauma of the trigeminal ganglion or adequate systemic alterations are the most effective means of destabilizing ganglionic latency of the herpesvirus with consequent neuronal peripheral virus shedding. Peripheral stimuli seem to have far less effect on ganglionic latency--at least in man. The authors report on a rare case of proven herpetic primary disease. The trigger was probably a small intrastromal foreign body which caused an unusual alteration of the cornea with long-standing healing disorders.

Combined Modality Therapy↗
PubMed1985

Recombinant HuIFN-gamma prevents herpes simplex keratitis in African green monkeys: demonstration of synergism with recombinant HuIFN-alpha 2.

Human interferon gamma (HuIFN-gamma) was found to prevent herpes-simplex virus (HSV 1) induced keratitis in monkey eyes, when administered topically at concentrations of greater than or equal to 3 X 10(5) reference units/ml. Protective efficacy demonstrated with lower concentrations of HuIFN-gamma in combination with low titers of HuIFN-alpha provided evidence of synergistic interferon activity in vivo. Tolerance problems observed in eyes affected by virus inoculation seem to be attributable to the experimental conditions including species heterology.

Animals↗
PubMed1985

[Therapy of herpetic diseases of the anterior eye segment].

Clinico-virologic investigations and the availability of the new antiviral drug Acyclovir have changed our therapeutic approach to deep herpetic diseases. Treatment of the symptoms alone with steroids should now be avoided. Basic treatment should consist of optimal dosages of Acyclovir. However, additional steroid therapy is still necessary. Significant progress in the treatment of dendritic keratitis is to be expected as soon as high-titer interferon preparations become commercially available. Treatment of dendritic keratitis with a combination of a modern antiviral drug and high-titer interferon will reduce the average time the corneal epithelium takes to heal from the present 6 days to 3 days. While considerable progress has been made in the treatment of herpes, no more than a step in the right direction has been taken with herpes zoster varicellosus virus, owing to its greater resistance to Acyclovir.

Acyclovir↗
PubMed1984

Combination therapy for dendritic keratitis. High-titer alpha-interferon and trifluridine.

Previous studies showed that the combination of trifluridine with human leukocyte interferon in the treatment of dendritic keratitis is effective, and that the best results were obtained with the highest titer then available (30 X 10(6) IU/mL). The present study was undertaken to see if an even higher titer (100 X 10(6) IU/mL) would be more effective. A statistically significant greater effectiveness of the higher titer could not be verified.

Drug Therapy, Combination↗
PubMed1984

[Corneal endotheliitis. Definition and clinical classification].

Corneal endotheliitis in the narrower sense is the term applied to immune reactions directed against the endothelial cells themselves. Virus antigens, histocompatibility antigens and autoantigens in the cell membrane represent the target for immune attack. The most significant clinical sign of endotheliitis is a strict correlation between the area of endothelial damage and the area of the (immune) precipitates.

Adult↗
PubMed1984

[Amebic keratitis: clinico-histopathologic case report].

The present paper describes a case of amebic keratitis in a 63-year-old female patient, who had been wearing hard contact lenses to correct myopia. The clinical course was characterized by early superficial corneal infiltrates accompanied by a marked iritis and excruciating pain. Later a ring abscess developed, combined with a disciform infiltration of the deep central stroma and a recalcitrant superficial corneal ulcer. The disease ran a very chronic course over more than 3 months. After various conservative treatments including topical steroids, antibiotics, antimycotic, and antiviral drugs, a penetrating keratoplasty had to be performed. The histopathologic examination of the corneal button revealed many encysted amebas and a few trophozoites which were classified by direct immunofluorescence as belonging to the genus Acanthamoeba (Hartmannella). Six months after keratoplasty the eye was quit without any signs of recurrence. As far as the authors know, this is the first reported case of an amebic keratitis associated with contact lenses.

Amebiasis↗
PubMed1984

Late wound complications after circular keratotomy for zoster keratitis.

We observed spontaneous melting and separation of circular keratotomy wounds in two zoster patients 8 and 23 years, respectively, after surgery. In one case, it could be demonstrated that the upper part of the unaffected keratotomy wound was formed by a large epithelial plug. It is probable that this type of wound may cause late complications under unfavorable conditions.

Adult↗
PubMed1983

[Endothelial cell loss after keratoplasty. Specular microscopic observations of immune reactions against donor endothelium].

Seven cases of immune reactions against donor endothelium after penetrating keratoplasty were analyzed in a prospective study. Cell loss during the immune reaction period varied between 25% and 81% and seemed to continue thereafter, though much more slowly. The authors discuss the complex etiology of post-keratoplasty endothelial cell loss and make suggestions for the diagnosis and treatment of classic endothelial immune reactions with special reference to specular microscopy.

Adult↗
PubMed1983

[Allergic granuloma of the conjunctiva].

The authors describe clinical and histopathologic findings in three patients with so-called allergic granulomas of the conjunctiva. The subconjunctival, yellowish, quite sharply delineated nodules are caused by local precipitation of an antigen-antibody complex (Splendore-Hoeppli phenomenon) with a subsequent surrounding foreign body reaction. The granulomas may represent a reaction to parasites. In the authors cases, however, no etiologic factor could be identified.

Adolescent↗
PubMed1983

[Oral acyclovir therapy of virologically proven intraocular herpes simplex virus infections].

Three patients with severe intraocular herpetic disease (focal serous iritis, endotheliitis, trabeculitis) were treated with oral acyclovir. Inflammatory signs subsided promptly although only low-dose steroid eye drops were administered in addition to antiviral therapy. Normally, the viral etiology of suspected intraocular herpetic disease remains equivocal because virologic proof is lacking. In these three cases, however, herpes simplex virus was isolated from the aqueous humor before initiation of therapy, and the viral nature of the diseases treated could thus be proven.

Acyclovir↗