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Biomedical subjects

R Sundmacher

Publications and source records attributed to R Sundmacher.

At least 199 records · Page 11Linked to original sources
PubMed1978

Role of debridement and interferon in the treatment of dendritic keratitis.

In a controlled clinical study, 42 patients with dendritic keratitis were treated either with thermocautery plus human leukocyte interferon (HLI) or with minimal wiping debridement plus HLI. The results show that the efficiency with which primary debridement was carried out, determined the success of further therapy using interferon. We conclude that interferon works basically as a prophylactic agent and needs the support of further antiviral measures to be effective against dendritic keratitis.

Debridement↗
PubMed1978

Herpes simplex virus types 1 and 2 in ocular disease.

In a continuous series of 457 patients with presumed herpetic eye disease, virus isolation and typing revealed 154 patients with herpes simplex virus type 1 and three patients with type 2 infections. In 219 isolates that were examined for neutralization by specific antisera, for growth in human fibroblasts, and, in part, for temperature sensitivity, there were found substantial strain differences in addition to the type-specific characteristics. The clinical features of each of the three type 2 infections are described in detail. A suggestive correlation found between clinical courses and virus growth characteristics of the type 1 strains indicates that further virologic differentiation of these strains would be useful.

Adult↗
PubMed1978

[Trifluorothymidin-prophylaxis of dendritic keratitis in steroid-treated herpetic keratouveitis (author's transl)].

In a randomized double-blind study trifluorothymidine was tested for its ability to prevent dendritic keratitis at a dose of 5 drops daily in patients with steroid-treated herpetic keratouveitis. The corneal epithelium of all 56 patients in the study was free of viral foci prior to initiation of therapy. In the placebo- "protected" group, 6 of 28 patients developed virologically confirmed dendritic keratitis while they were under steroids, whereas all 28 trifluorothymidine-protected patients showed uneventful courses of their steroid regimes. No clinically relevant side-effects of trifluorothymidine prophylaxis were observed in this study.

Clinical Trials as Topic↗
PubMed1978

[Suture loosening after keratoplasty and methods for correction (author's transl)].

An analysis of histological and clinical findings in 102 keratoplasties confirms that suture loosening is often associated with defects found in Bowman's membrane and in the superficial stroma. These structures of the cornea serve as the major supporting layer for a suture. In cases of more generally weakened corneal tissue, like in keratokonus, suture loosening is also a relatively frequent occurance. In this paper we report on our experiences with correction methods, post-operative care and immunoprophylaxis after correction.

Corneal Transplantation↗
PubMed1978

[Postoperative fitting of soft contact lenses in aphakia. (A trial with Weicon 38 and Weicon 72) (author's transl)].

In a controlled clinical pilot study 48 aphakic eyes were fitted with HEMA soft lenses on the 3rd postoperative day. An optically satisfactory and wearable fit was obtained neither with the conventional hydrated Weicon 38, nor with the highly hydrophilic Weicon 72. The main reasons were centralizing and motility defects of the lenses, which might be eliminated by an improved lens design. A further 57 patients showed an increase in corneal thickness following cataract extraction. The early fitting of permanent soft aphakic lenses should be delayed until the 4th day postoperatively, by which time the oedema has reduced and the cornea has reached approximately its pre-operative thickness.

Cataract Extraction↗
PubMed1978

[The influence of Poly-HEMA and silicone contact lenses on corneal thickness (author's transl)].

The influence of permanent wear contact lenses (highly oxygen permeable silicone and less oxygen permeable highly hydrophilic Poly-HEMA) on corneal thickness was evaluated in 22 volunteers. Poly-HEMA lenses provoked a highly significant increase in corneal thickness not correlated with the fitting technique, while no significant variation in corneal thickness was observed under silicone lenses.

Contact Lenses, Hydrophilic↗
PubMed1977

Comparative evaluation of human leukocyte and fibroblast interferon in the prevention of herpes simplex virus keratitis in a monkey model.

The prophylactic potency of topically applied human leukocyte interferon and human fibroblast interferon was compared in a monkey model with herpes simplex virus type 1-induced keratitis. Both interferons effectively prevented keratitis at 1.9 X 10(6) U of activity per ml but were ineffective at 1.9 X 10(3) U/ml. Slight differences between human leukocyte interferon and human fibroblast interferon observed at the level of 1.9 X 10(5) U/ml were not statistically significant.

Animals↗
PubMed1977

[Bilateral dendritic pseudokeratitis (Richner-Hanhart syndrome)].

A Turkish baby was treated several times for bilateral "recurrent dendritic keratitis" before a diagnosis of Richner-Hanhart syndrome could be made (recessively inherited keratosis palmaris et plantaris with pathognomonic corneal dystrophy). No effective conservative treatment has been reported in the literature for the recurrent eye pain. Highly hydrophilic contact lenses gave prompt and absolute symptomatic relief.

Child↗
PubMed1977

[The pathophysiology of recurrent herpes simplex virus disease (author's transl)].

Clinical recurrence of herpes simplex virus (HSV) disease may occur when latent HSV escapes the state of latency and begins again to enter the lytic reproduction cycle. Recent investigation revealed HSV latency in peripheral sensory ganglia and an intra-axonal viral transport between the periphery and the appropriate sensory ganglia. As all previous attempts to demonstrate latent HSV in ocular structures have failed, the neuronal hypothesis for HSV latency and recurrences is the most probable. The consequences for therapy and prophylaxis of HSV disease are discussed.

Animals↗
PubMed1977

[Keratoplasty in childhood (author's transl)].

Report on 36 keratoplasties (30 eyes) in children up to 15 years of age. An efficient postoperative care was of critical importance for the final outcome. The specific problems are discussed. Regarding the fact that generally children are only operated on in case of heavy corneal disease which brings about a higher risk of graft failure our results may be judged as "fair": 63% of the transplants were optically clear; 43% exhibited good and 30% fair functional results. The best results were achieved with keratoplasties in corneal dystrophies (keratoconus included). Another group with good results was that with herpetic corneal disease, whereas transplants after heavy perforating injuries mostly failed. A beter postoperative medical collaboration and consultation is needed to improve final results. This is especially true for correcting operative measures (loosening sutures) and for therapy and prophylaxis of graft reactions.

Age Factors↗
PubMed1977

[Allograft rejection reactions after keratoplasty (author's transl)].

Immune reactions against corneal transplants cause most of the graft failures during the first 24 months after keratoplasty. This is partly due to inadequate diagnosis and therapy. After a short discussion of the experimental and clinical background, different kinds of characteristic immune reactions are demonstrated by case descriptions and photos. The importance of immune reactions is substantiated by an evaluation of 88 recently performed keratoplasties. Finally, detailed suggestions are made for prophylaxis and therapy of postkeratoplasty immune reactions.

Adolescent↗
PubMed1977

A controlled comparison of two therapeutic soft lenses in a clinical model.

Laboratory data of a new, highly hydrated contact lens (Weicon 72) indicated that it might be therapeutically superior to the known Weicon 38. The great variability of therapeutic contact lens cases, however, makes a sound clinical evaluation difficult. Therefore the two lenses were tested in a clinical model using patients with traumatic superficial corneal defects. The results were statistically significant, the Weicon 72 proving to be superior to the Weicon 38.

Contact Lenses, Hydrophilic↗
PubMed1977

[Thygeson's superficial punctate keratitis (author's transl)].

Ten cases of Thygeson's bilateral punctate epithelial keratitis were observed during a two year period. The diagnosis, therapy and prognosis are discussed. The common erroneous diagnosis of herpetic keratitis may lead to corneal damage as a result of too intensive therapy. Highly hydrophilic contact lenses have proven to be a valuable aternative to steroid therapy. The etiology remains obscure. Viruses were not detected with either tissue culture technique or with electron microscopy.

Adolescent↗
PubMed1977

[Herpes therapy and prophylaxis. II. Results of a survey of practicing ophthalmologists (author's transl)].

Between December 1975 and April 1976, 2,300 ophthalmologists in the Federal Republic of Germany and West-Berlin were asked about their experiences with different forms of therapy and prophylaxis for herpetic eye diseases. 15 questions were answered by 965 ophthalmologists (42%). The answers not only reflect their preferences and experiences, but could also initiate a new evaluation of many diagnostic, therapeutic and prophylactic methods.

Humans↗