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Biomedical subjects

R Sommer

Publications and source records attributed to R Sommer.

At least 109 records · Page 6Linked to original sources
PubMed1977

[The value of the blood xylose test in children with the malabsorption syndrome (author's transl)].

Blood xylose levels were studied 30, 60 and 90 minutes after oral administration of D-xylose in 121 patients aged 2 months to 12 years with symptoms of malabsorption. The results show that the 60-minute test aline is sufficiently accurate and the dose of 15g xylose/m2 surface area seems perferable to a uniform dosage of 5g xylose. Reference values of blood xylose were determined in children with normal intestinal mucosa and prove a significant difference between babies and elder children. Comparison between the results of the xylose test in normal children and in different conditions of intestinal mucosa showed that the one-hour blood xylose test is of little value in the selection of cases requiring primary diagnostic intestinal biopsy in children with malabsorption. This test, however, might be valuable in the control of patients with diagnosed coeliac disease and as a screening test for other members of those families.

Age Factors↗
PubMed1976

[Quality control of coagulation tests (author's transl)].

The results of quality control of coagulation tests from intralaboratory control programmes are reported and compared with interlaboratory surveys. The test programme includes the following assays: the thromboplastin time (Quick), the partial thromboplastin time and the thrombotest. It can be seen from the results of the thromboplastin time that reliable figures were obtained from intralaboratory quality control examinations only (CV=7% to 13%). In comparison to these results great differences were found in interlaboratory surveys (CV=15% to 30%). The result of interlaboratory surveys of the thrombotest demonstrated a CV of 15% to 20%. The intralaboratory quality control of the partial thromboplastin time showed satisfactory reliability (CV=7.4%). Satisfactory conformity of results was obtained between different laboratories only by using common reagents (CV=8.7%). Possible factors responsible for deviations in laboratory examinations are discussed and proposals for improvement in the realibility of coagulation tests are made.

Blood Coagulation Tests↗
PubMed1976

[Studies on the accuracy and precision of total serum cholesterol in regional interlaboratory trials (author's transl)].

The between-run precision of the Liebermann-Burchard reaction modified by Watson was, in our laboratory, 2-3%, the within-run coefficient of variation was 1-2%. The between-run precision of the enzymatic test was 3-4%, the within-run coefficient of variation was 3%. The regression analysis of 92 serum specimens from patients was y = -17.31 + 1.04 chi, the coefficient of regression was r = 0.996. Interlaboratory trials of serum cholesterol were studied in the normal and pathological range. Lyophilized samples of serum prepared commercially and from fresh specimens from patients were analysed by the method of Liebermann-Burchard as well as by the enzymatic procedure. Acceptable results estimated by Liebermann-Burchard were obtained in the different laboratories after using a common standard of cholesterol. The coefficient of variation of the enzymatic test in the interlaboratory trial was higher in comparison to the Liebermann-Burchard reaction. Methodological difficulties of the Liebermann-Burchard reaction are discussed and compared with the specific, enzymatic assay.

Cholesterol↗
PubMed1975

[Blood-sugar determination with the Reflomat (author's transl)].

A total of 710 blood samples was tested with the new Reflomat apparatus. There was a good correlation with the GOD-Perid method (correlation coefficient for serum r = 0.993; for whole blood r = 0.983). In two thirds of the cases deviation from the reference value was less than +/- 7 mg/dl for serum, less than +/- 14 mg/dl in 95%, the corresponding values for whole blood +/- 11 mg/dl and +/- 22 mg/dl, respectively. The percentage deviation from the reference value was below +/- 13% for serum, and under +/- 22% for whole blood in 95% of measurements. In the range under 100 mg/dl variations were much more marked for whole blood than at the higher levels (100-350 mg/dl). The accuracy of the Reflotest¿ system and the accuracy from day to day proved to be exceptionally good. In the range 100-200 mg/dl the variation coefficient was between 1 and 2%.

Blood Glucose↗
PubMedDate not supplied

Massive digitoxin intoxication treated with digoxin-specific antibodies in a child.

A 20-month-old girl with massive digitoxin intoxication (initial digitoxin serum level: 629 ng/ml) was successfully treated with digoxin-specific antibody fragments (Fab). She presented with moderate signs of digitalis toxicity (somnolence, bradycardia, first-degree AV block) and improved rapidly during fractional Fab administration. Free serum-digitoxin disappeared after 6 vials of Fab (480 mg), but was measurable again on days 6 and 7. This case demonstrated that digoxin-specific antibodies, despite a 30-100 times lesser affinity for digitoxin, are effective in massive digitoxin intoxications. A rebound phenomenon may occur several days later and should be taken into consideration.

Digitoxin↗
PubMedDate not supplied

Sons and daughters of parents in a support organization.

Earlier surveys of a parents' support organization revealed a 3:1 ratio of parents of sons to parents of daughters. Three possible explanations for this ratio were considered based on differential onset, behavioral differences, and marital status. A re-analysis of survey data indicated that the most reasonable explanation of the gender difference is the greater propensity for anti-social behavior on the part of sons, leading to increased parental needs for support and outside assistance.

Adolescent↗