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Biomedical subjects

R Sinha

Publications and source records attributed to R Sinha.

At least 199 records · Page 11Linked to original sources
PubMed1970

Serological response to cholera revaccination in a semi-closed community in Calcutta.

Serological response to cholera revaccination has been studied in a semi-closed community consisting of individuals mostly in the 2-20-years age-group. The subjects had been inoculated against cholera every year at the beginning of the local epidemic season. Pre- and post-vaccination sera were obtained from 29 subjects inoculated with cholera vaccine (test group) and 28 from subjects inoculated with TAB vaccine (control group). These sera were tested for vibriocidal and agglutination titres. The geometrical means of the vibriocidal and agglutination titres of the post-vaccination sera in the test group rose by 490% and 463% respectively. This booster effect was observed mostly in individuals in the 2-14-years age-group, who had low titres (vibriocidal </=320 and agglutination </=40) in their prevaccination samples. Revaccination, therefore, appears to be useful as a booster for individuals having low titres.

Adolescent↗
PubMed1967

Cholera carrier studies in Calcutta in 1966-67.

Cholera carrier studies have been in progress in Calcutta since April 1966, in areas of high endemicity with a population of about 13 000. Carriers are traced through periodic examinations of samples from latrines, users of vibrio-positive latrines, contacts of cases of cholera and apparently healthy persons.The latrine survey showed that 46.2% of the latrines were infected, and brought 54 carriers to light; the over-all carrier rate in the study area was estimated as 1.3%. The carrier rate among household and family contacts of hospital cases of cholera was 1.6%. None of the contacts of 9 persons with choleraic diarrhoea was positive. Vibrios were also isolated from water and flies near positive latrines.The results indicate that carriers can occur even in the absence of overt disease, that infection persists in many households, and that carriers may transmit the infection.

Adolescent↗