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Biomedical subjects

R Sinha

Publications and source records attributed to R Sinha.

At least 181 records · Page 10Linked to original sources
PubMed1985

Renal allograft rupture and its management.

Rupture of the renal allograft, although a rare complication, was encountered in 11 of our 152 renal transplants. The commonest cause was associated acute rejection. We treated our patients conservatively by repair of the rupture and antirejection therapy. 8 of 11 kidneys could be saved by this method. The patient survival was 8 out of 11. Deaths were unrelated to the graft rupture.

Biopsy↗
PubMed1980

Hypolipidemic activity of guggal resin (Commiphora mukul) and garlic (Alium sativum linn.) in dogs (Canis familiaris) and monkeys (Presbytis entellus entellus Dufresne).

1. The identification of cholesterol as a constituent in the genesis of coronary artery disease in man and experimental animals are well documented. 2. The hypolipidemic effects of Commiphora mukul (guggulu) and Alium sativum (Garlic powder) were screened in dog and Presbytis monkeys. 3. Progressive decrease in the mean values of cholesterol, triglycerides and phospholipids were conspicuous for forty eight hours following the administration of guggulu/garlic powder. 4. 25 mg/kg body weight garlic powder was more effective in lowering the serum cholesterol and triglycerides as compared with that of guggulu. 5. A comparative hypolipidemic action of the two compounds is discussed.

Animals↗
PubMed1975

Haemoglobin norfolk in nepali gorkhas.

Three instances of fast moving haemoglobins in heterozygous form have been found in Indian soldiers of Nepali Gorkha, during a routine screening for abnormal haemoglobins. The affected individuals were not related and seemed clinically well.

Adult↗
PubMed1975

Antibody response in the intestinal secretions of volunteers immunized with various cholera vaccines.

The efficacy of various cholera vaccines in eliciting an intestinal antibody response was assessed in human volunteers who received oral live, oral killed, or parenteral cholera vaccines, or placebo. The intestinal immune response in terms of antibacterial and antitoxin antibodies was determined 2 and 4 weeks after immunization. By means of the mouse peritoneum opsonization assay and the infant mouse protection test, antibacterial activity could be detected in the intestinal secretions of volunteers who had been immunized either orally or by the parenteral route. Significant protective activity and duration of immunity were observed with the oral killed vaccine. The bacteriological data indicated the absence of significant intestinal colonization of the live attenuated strain after oral administration, and probably explains the observed lack of effectiveness of the oral vaccine compared with that of the killed vaccine. The predominant immunoglobulin class of intestinal antibody was found to be IgA. None of the vaccines used in the study elicited significant antitoxin activity in the intestinal secretions, as determined by the skin permeability neutralization test.

Adult↗