Pelvis radiographs of 47 children with slipped capital femoral epiphyses (SCFE) and 24 without a hip disorder were reviewed in a retrospective study by four readers to determine the skeletal age by the Oxford method. 72% of the children suffering from SCFE had a body weight above the standard level but a normal body height at the time of diagnosis. The mean chronologic age was 3 years higher than the skeletal age determined by the Oxford-score. The linear regression analyses showed that children with SCFE have had a skeletal maturation delay in comparison with the normal group at the beginning of the age period in question. This deficiency became greater as chronologic age increased. All children with the SCFE disease showed a nearly uniform skeletal age clearly below the bone age standard irrespective of their chronologic age. These results, in connection with obesity in most cases, support the idea of hormonal disorders with delayed skeletal maturation development in the aetiology of SCFE disease.

Adolescent↗

PubMedDate not supplied

[Comparative studies of the sensitizing capacity of drugs used in herpes simplex].

Experimental sensitization of guinea pigs with 9 commonly used or still tested antiviral drugs revealed a very low sensitizing power for these when compared with tromantadine. In a former investigation tromantadine had been shown to be a moderate sensitizer. While ethoxyuridine, bromovinyl deoxyuridine and phosphono formiate gave no response in the animals, aciclovir, vidarabine, idoxuridine, trifluorothymidine, proclu and an extract of lemon balm (Melissa officinalis) only induced weak reactions in the guinea pigs. Thus these drugs only bear a low risk of sensitization if compared with tromantadine. The findings are in good accordance with the low number of observed clinical cases. Allergic reactions to idoxuridine which occasionally might occur may be encountered by effective treatment with aciclovir or vidarabine as no cross-reactivities seem to exist.

Animals↗