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Biomedical subjects

R Schulze

Publications and source records attributed to R Schulze.

At least 37 records · Page 2Linked to original sources
PubMed1994

[Long term dilatation after unsuccessful percutaneous transluminal coronary angioplasty].

Between August 1991 and December 1993, a total of 7011 percutaneous transluminal coronary angioplasties (PTCA) were performed. In 24 of them, the acute results were unsatisfactory, an autoperfusion balloon catheter was tolerated without complications and prolonged inflation (30 min to one hour) brought no improvement. In these 24 patients (22 men, two women; mean age 60 [33-81] years) the duration of inflation was, if possible, increased to at least 6 hours. In three patients the inflation had to be terminated after 2 or 4 hours, respectively, because of angina or for technical reasons. In 18 of the 24 patients subsequent angiography demonstrated residual restenosis of less than 50%, with a mean degree of stenosis of 18 +/- 14%. But lasting dilatation was not achieved in 6 patients: occlusion persisted in one and marked residual stenosis in two patients, while stent implantation was required in three. These results indicate that, in case of dissection or acute occlusion with failure after prolonged balloon inflation of 30 to 60 min, extending the duration of inflation to many hours can often produce good results so that stent implantation can be avoided.

Adult↗
PubMed1994

[Non-surgical closure of atrial septal defect in adults. Experiences with the Rashkind and the Sideris occluder].

The possibility of closing an atrial septal defect in adults by means of a percutaneously introduced catheter with an umbrella-type occluder was tested in seven consecutive patients with this defect (two men and five women, aged 35 to 69 years). The diameter of the defect (echocardiographic measurement) ranged from 7 to 25 mm, the left to right shunt from 11% to 54% of pulmonary flow and the pulmonary artery pressure from 24/8 to 110/25 mmHg. In one patient no attempt was made to close the defect because of its size (invasively measured: 40 mm). In another patient the method failed. Closure was successful in four of the patients (left to right shunt < 5%), while in a fifth patient a haemodynamically significant residual shunt (38%) remained, but was closed 2 months later with a second occluder. In one of the patients a portion of the device embolized to the pulmonary artery from which it was removed by catheter.--Thus the intervention was successful in five of six patients. This experience suggests that this type of occluder can also be used successfully in adults.

Adult↗
PubMed1994

[A new radiation protection device for cardiologists active in interventional radiology].

The radiation protection system up to now has been in the form of a lead glass pane and a lead curtain on the examination table. As new equipment we used a leaded rubber cover (Pb 0.75 mm) extending from the foot to the rib cage of the patient and a 60-cm high and 70-cm wide stand, reinforced with leaded rubber (Pb 1.0 mm) fixed onto the foot switch. During the period of 2 months the total radiation dose in 156 coronary angioplasties and 71 diagnostic heart catheterizations was measured on the hand, thorax, lower leg and foot of the examiner using ring and placet dosimeters. The dose was measured for a further 2 months, during 152 coronary angioplasty and 66 diagnostic heart catheterizations without the new extra radiation protection equipment. The catheterization procedure was not basically impeded through the lead cover and the lead stand. The radiation dose experienced by the examiner was reduced by 96.8% on the hand, 98.6% on the thorax, 98.8% on the lower leg, and by 99.5% on the foot.

Angioplasty, Balloon, Coronary↗
PubMed1993

[Extraction of a ruptured PTCA balloon catheter].

While attempting angioplasty of a very tight and long circumflex lesion with a metal-shafted monorail catheter, the flexible part of the balloon catheter shaft broke off within the guiding catheter. The lost piece of catheter was then retrieved from the coronary artery by using an on-the-wire balloon catheter that was inflated inside the distal end of the guiding catheter.

Angioplasty, Balloon, Coronary↗
PubMed1993

[High frequency rotational angioplasty (rotablation) after unsuccessful balloon dilatation].

From April 1991 to March 1992, 2442 balloon dilatations were carried out. In 36/2442 patients (1.5%), a high-degree coronary stenosis or a coronary occlusion could be passed with a guide wire, but not with a balloon catheter or a recanalization catheter. In 32 of these 36 cases, the conventional coronary guide wire could be exchanged with the 0.009 inch guide wire required for rotational angioplasty. A sufficient increase in stenosis diameter could be attained by rotablation alone in 15 cases. A balloon dilatation was carried out after the rotablation in 17 cases. In one case, implantation of a stent was necessary in addition. The mean degree of stenosis was reduced from 95 +/- 10 to 33 +/- 6%. Thus, high-grade coronary stenoses and occlusions which cannot be passed with a balloon catheter, can be treated successfully with rotablation in a high percentage of cases.

Adult↗
PubMed1992

Coincidence of primary myelodysplastic syndrome and non-Hodgkin lymphoma.

A 60-year-old patient is presented with primary myelodysplastic syndrome classified according to the criteria of the French-American-British classification as chronic myelomonocytic leukemia and with a hyperviscosity syndrome. We found a monoclonal gammopathy with a very high serum immunoglobulin M level. There is strong evidence for coincidence of myelodysplastic syndrome and Waldenström's macroglobulinemia in this patient.

Humans↗
PubMed1990

Disinfection of bacteria in water systems by using electrolytically generated copper:silver and reduced levels of free chlorine.

As an alternative disinfectant to chlorination, electrolytically generated copper:silver (400 and 40 micrograms/L copper and silver, respectively) with and without free chlorine (0.3 mg/L) was evaluated over a period of 4 weeks in indoor and outdoor water systems (100 L tap water with natural body flora and urine). Numbers of total coliform, pseudomonas, and staphylococci were all less than drinking water standards in systems treated with copper:silver and free chlorine and systems treated with free chlorine alone (1.0 mg/L). No significant differences (p less than or equal to 0.05) in bacterial numbers were observed between systems with copper:silver and free chlorine and those with free chlorine alone. Overall, free-chlorine treatments (0.3 or 1.0 mg/L) showed significantly lower heterotrophic plate numbers than those without free chlorine. When challenged with a natural Staphylococcus sp. isolate, water with copper:silver and free chlorine had a 2.4 log10 reduction in bacterial numbers within 2 min, while free chlorine alone or copper:silver alone showed 1.5 and 0.03 log10 reductions, respectively. Addition of copper:silver to water systems may allow the concentration of free chlorine to be reduced while still providing comparable sanitary quality of the water.

Bacteria↗
PubMed1990

[The effect of dipyridamole on the results of allogenic kidney transplantation].

In a prospective randomized trial the anti-thrombotic effect of dipyridamole was studied in 64 patients after cadaveric kidney allotransplantation. The frequency of early graft function was significantly higher in the control group, whereas the incidence of arterial and venous thromboses were not different. One-year graft survival could not be improved by dipyridamole. Therefore, dipyridamole should not be recommended in cadaveric kidney allotransplantation.

Cadaver↗
PubMed1990

[The effect of different factors on the immediate transplant function. A retrospective study of 172 kidney transplants].

The influence of different factors on the immediate function of the transplant was investigated retrospectively in 172 patients. The immediate function of the transplanted kidney was influenced negatively by dehydration of the patient, by intraoperative decrease in blood pressure above 30 mmHg, by an prolonged cold ischemia time, and by the "handling time".

Cold Temperature↗
PubMed1989

[Disseminated superficial actinic porokeratosis. A case report].

It is reported on a 72-year-old pensionary who developed one year ago a disseminated superficial actinic porokeratosis on the lower legs after chronic sun exposure during twenty summers. The diagnostic features and therapeutic schedules are summarized and the role as praecancerosis is emphasized.

Aged↗
PubMed1987

[Transplantation antigen specific rosette test and its inhibition with autologous serum--a new immunologic method for predicting rejection crisis following allogeneic organ transplantation].

A combination of transplantation-antigen-specific rosette test with inhibition of rosette formation, using autologous serum, was used in postoperative follow-up checks on patients who had undergone allogeneic kidney transplantation and proved successful in early diagnosis or prediction of rejection episodes even before clinical manifestation. The numbers of antigen-detecting and antigen-binding cells differed considerably from each other, depending on patients who had undergone kidney transplantation. Almost complete inhibition of antigen detection was generally achieved by addition of patient serum. If sensitization to alloantigen in excess of the limit value (30 RBZ/10(3) KHZ) is accompanied by rosette formation with autologous serum addition in excess of about 18 RBZ/10(3) KHZ, clinically relevant rejection can be expected to occur after another two or three days and will have to be treated by immunosuppressives. Such partial or even complete elimination of rosette inhibition is usually only of short length (one day) and has rarely been observed to last longer. No rejection calling for treatment will develop, on the other hand, as long as blocking serum factors provide for high-stability inhibition of any bond of transplantation antigen (rosette formation). Constantly low rosette formation with serum addition and without was exhibited by control persons (blood donors, patients with cerebrocranial trauma) in daily examinations. Limit values of 18 or 30 RBZ/10(3) KHZ were not surpassed.

Graft Rejection↗
PubMed1986

Molecular characterization of a meiotic recombinational hotspot enhancing homologous equal crossing-over.

We have cloned and sequenced a meiotic recombinational hotspot between the A beta 3 and A beta 2 genes in the major histocompatibility complex (MHC) of the mouse. This recombinational hotspot in the Mus musculus castaneus cas3 haplotype was previously localized to a region of 9.5 kb of DNA in which five independent crossing-over events occurred at the unusually high frequency of 0.6%. Aside from cas3, the hotspot appears to be absent in many other MHC haplotypes. We have now confined the five recombinational breakpoints to a stretch of 3.5 kb of DNA. From the nucleotide sequence around the recombinational breakpoints, determined in the parental cas3 and b haplotypes as well as for two recombinant haplotypes, we show that the two recombinant haplotypes were generated by homologous equal crossing-over and place the breakpoints within two non-overlapping stretches of 10 and 36 bp, respectively. Comparison of the DNA sequences of the hotspot-positive cas3 and the hotspot-negative b haplotypes reveals a number of differences, in particular, a CAGA-repeat sequence which is present in CAS3 in six, but only four copies in C57BL/6 DNA. This repeat sequence is reminiscent of one in a previously characterized hotspot in the E beta gene.

Animals↗