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Biomedical subjects

R Scholler

Publications and source records attributed to R Scholler.

At least 91 records · Page 5Linked to original sources
PubMed1981

Interpretation of plasma luteinizing hormone assay for the collection of mature oocytes from women: definition of a luteinizing hormone surge-initiating rise.

Analysis of plasma luteinizing hormone (LH) assays (4 assays per day) permits the discernment of the onset of the physiologic effects of ovulatory release. This threshold value of LH plasma concentration (LH surge-initiating rise, LH SIR) is determined for each cycle in terms of the average baseline level of the previous day. The chronology of follicle and oocyte maturation after LH SIR is similar to that which follows chorionic gonadotropin (hCG) administration: none of the 20 patients, compared with 2 out of 10, had ovulated when laparoscopy was performed 30 to 35 hours and 36 to 38 hours after LH SIR time, respectively; 1 out of 3, 9 out of 14, and 5 out of 5 patients had an in vitro fertilized egg when oocytes were collected 30 to 32, 33 to 35, and 36 to 38 hours after LH SIR time, respectively. Thus the oocyte can be collected 34 to 35 hours after the LH SIR; at this point ovulation has not occurred and the oocyte is capable of being fertilized.

Adult↗
PubMed1981

[Recovery of preovulatory human oocytes (author's transl)].

Rapid radio-immune assaying of LH was carried out four times daily on 52 women in the preovulatory phase of the cycle. This method enables the precise detection of the LH surge and recovery of the mature oocyte by laparoscopic aspiration of the follicular content, just before ovulation, which is between 28 and 36 hours after the start of the LH surge. The oocytes was recovered in 27 out of 41 patients with a normal cycle (66%). The rate of recovery per follicle aspirated is comparable in a natural cycle to that after treatment with Clomid (80 to 84%).

Adult↗
PubMed1980

FSH and LH pituitary reserve and output in the postmenopause.

FSH and LH basal levels and their cumulative responses following LH-RH administration were determined along with plasma estradiol levels in postmenopausal patients. 89 postmenopausal patients were studied. They were divided into four groups according to the time elapsed since their menopause. Group I being less than 2 yr postmenopausal, Group II between 2 and 5 yr, Group III 5--10 yr and Group IV 10 yr or more postmenopausal. Blood was drawn before a bolus intravenous injection of 100 micrograms of LH-RH was given and at different time intervals after the injection. FSH, LH and plasma estradiol were assayed. FSH and LH cumulative responses after LH-RH (CR) and total cumulative responses (TCR), as defined by the surface area comprised between the tracing and a horizontal line drawn through the basal level (CR) or the X-axis (TCR) were calculated by planimetry. The basal levels of FSH tend to increase with age, with a maximum in the 3rd age group and a decline thereafter. A similar trend, though less outspoken, was seen in the LH basal levels. FSH cumulative responses after LH-RH (as expressed by the mean increment (delta), maintained over the 2 h duration of the test) were significantly lower than the corresponding FSH basal levels and appeared to remain at the same level throughout postmenopause. In contrast, LH cumulative responses after LH-RH, expressed in the same way, compared with corresponding LH basal levels. They were highest in the younger age group, associated with still appreciable estradiol levels and declined in the subsequent age groups. LH-TCR and LH-TCR : FSH-TCR ratio showed a similar trend as LH cumulative responses. It is suggested that this peculiar pattern, is related to estradiol levels.

Age Factors↗