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Biomedical subjects

R Schmitz

Publications and source records attributed to R Schmitz.

At least 91 records · Page 5Linked to original sources
PubMed1981

Studies in an animal model on the effectiveness of adjuvant chemotherapy with 5-FU and BCNU in cases of colorectal adenocarcinoma.

The effect of combined chemotherapy with 5-FU and BCNU on ten well differentiated human adenocarcinomas of different stages following xenotransplantation and growth in syngeneic balb/c nude mice collectives was investigated. With a tumor take of approximately 90%, it was found that marked remissions up to 43% of the original volume were only obtained with those transplant tumors initially classified as Dukes A and B; carcinomas graded Dukes C/D underwent no significant remission. Pathohistological findings during tumor remission revealed large amounts of fibrotic tissue together with surviving nests of tumor cells.

Adenocarcinoma↗
PubMed1981

[Compression treatment in venous insufficiency and lymphedema].

Ambulant therapy of varicose vein conditions is only possible with compression bandages. Doctors are often very cautious with regard to compression bandaging because they believe that it cannot be learned. The paper is intending to show that such fears are unfounded. The physical principles for the individual steps in compression bandaging are therefore described. If these principles are heeded, there are no longer any obstacles to the practical application of compression bandages.

Bandages↗
PubMed1981

[Compression dressings for the legs].

There are fundamental differences between a phlebological and a lymphological compression bandage. In venous congestion, the bandage reduces the edema; it is unable to do this to the same extent in lymphatic congestion. On the contrary, there it is only a link in a chain of measures. The actual reduction of the edema takes place by manual lymphatic drainage and instrumental expression. The intervals between the sessions are bridged over with the compression bandage. The requirement on the compression bandage in lymphatic edema is great firmness, i.e. high working pressure, but minimal resting pressure. This can be achieved technically either with gelatin of zinc or (in application of elastic bandages) by winding round many turns of the bandage with a slight pull. The material requirement is greater than with a phlebological bandage. On the other hand, cushioning is simpler. Care should be taken that the deep transverse folds near to the joint are bridged over with foam rubber in such a way that the bandage does not sink into them. The locking effect of the folds can thus be further intensified.

Bandages↗
PubMed1980

[Calomel].

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Humans↗
PubMed1980

[Adjuvant chemotherapy of human colorectal adenocarcinoma after growth on mice with congenital thymic dysplasia ("nude"). 1. Experiments to test the feasibility of combined chemotherapy with VCR and 5-FU (author's transl)].

Five-week-old syngeneic, female BALB/c nude mice were injected i.p. with vincristine (VCR) and 5-fluorouracil (5-FU) to determine the LD 20 of these drugs under spf-conditions. One hundred fifty animals were given dosages similar to those administered clinically, and a complete autopsy was performed on all nude mice. Whereas VCR caused splenic atrophy and regressive changes in the jejunal epithelium, the application of 5-FU was followed mainly by regressive changes in the transitional epithelium of the bladder, and 67% of the animals developed pneumonia. These pathohistological changes were also seen after a combined chemotherapy, and a temporary leucopenia was reversible. These experiments showed that chemotherapy of nude mice with VCR and 5-FU is possible provided they have been successfully xenotransplanted with human colorectal adenocarcinomas.

Adenocarcinoma↗
PubMed1980

Adjuvant chemotherapy of human colorectal adenocarcinoma after growth on mice with congenital thymic dysplasia ("nude"). 2. Tumor remission following treatment with 5-FU and VCR of xenotransplanted primary human colorectal adenocarcinomas.

The poor 5-year survival rate of patients with malignant colorectal tumors calls for clarification of the question as to whether it is advisable to carry out postoperative adjuvant chemotherapy. In the present study a simple "in vivo" test is described with which the sensitivity of individual human adenocarcinomas of the colon, primary xenotransplanted onto syngeneic "nude"-mice suffering from congenital thymic dysplasia, to cytostatic therapy with 5-FU and VCR could be determined. Five of six primary xenotransplanted tumors showed a significant reduction in size following combined therapy with these drugs in doses comparable to those administered clinically, whereas one of the transplanted tumors remained unresponsive to therapy. On the basis of these results it is absolutely necessary that a comparison be carried out between the rate of tumor remission in groups of patients and animals undergoing the same chemotherapy.

Adenocarcinoma↗
PubMed1980

[Lipoedema].

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Adolescent↗
PubMed1980

[Animal experiments using adjuvant 5-FU and BCNU chemotherapy in stomach cancer].

Primary xenotransplantation of tissue from six human gastric cancers onto 'nude' mice was followed by a positive tumor take in all cases. One tumor showed aggressive growth and underwent a series of four passages on 'nude' mice. Characteristics of this tumor were an increasing speed of growth and pathohistological changes in the growth pattern. Chemotherapy with 5-FU and BCNU was followed by a decrease in volume compared with untreated controls. On the basis of our results a comparison between groups of patients and tumor-bearing 'nude' mice undergoing this chemotherapy is justified.

Animals↗
PubMed1979

[Compression bandages in the so-called leg disease].

The compressive bandaging of limbs as a supportive therapy in venous insufficiency and lymphedema is neither difficult, nor a mystery. The compressive therapy is to be applied exclusively to walking patients. The principles of some types of compressive bandages are explained.

Arterial Occlusive Diseases↗
PubMed1978

[Not Available].

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History of Pharmacy↗