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Biomedical subjects

R Schmitz

Publications and source records attributed to R Schmitz.

At least 73 records · Page 4Linked to original sources
PubMed1984

Effects of steroid hormone therapy on primarily xenotransplanted human colorectal adenocarcinomas.

Primary xenotransplantation of six different human colorectal adenocarcinomas onto nude mice yielded a mean tumor take of 85%. Administration of steroid hormones induced tumor remissions in some cases. Neither the stage of the original patient's tumors nor their hormone receptor content seemed to be related to the result of the hormone therapies. It is concluded that some colorectal cancers can be treated as hormone-sensitive tumors.

Adenocarcinoma↗
PubMed1983

["Classic drugs"].

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Aminophylline↗
PubMed1983

[Phase II study of AMSA in adults with acute therapy-refractory leukemias].

The acridine derivative AMSA, Amsacrine, is a new anticancer drug which was effective in patients with advanced AML and ALL in studies performed in USA. In a multicenter phase II trial we treated 27 patients with acute resistant leukemia with AMSA. All presented progressive disease following several drug combination regimens. Out of the 25 evaluable patients 5 were resistant to primary therapies, 13 were in 2nd relapse, 6 in 3rd, and 1 in 4th relapse. Dosage was 75 mg/m2, iv, day 1-7, all 3-5 weeks. On an average, only 76% of the planned dose per cycle could be given, due to severe leucopenia. From 21 patients with ALL, 1 CR and 3 PR were observed; the 3 patients with ALL presented 1 CR and 1 PR. 1 AUL showed progressive disease. In all patients a marked cell reduction could be observed in the peripheral blood. The general tolerance was good. The most important side-effect was bone-marrow toxicity, 48% (12/25) presented leucopenia less than or equal to 600/mm3, 5 (20%) had fatal septic complications. All 5 early death presented high initial leucocyte counts of greater than or equal to 32.000 mm3 as a common risk factor. In conclusion, AMSA is an effective drug in heavily pretreated patients with AML and ALL.

Adolescent↗
PubMed1983

[Not Available].

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History of Pharmacy↗
PubMed1983

Androgens as promoters of colon carcinogenesis.

The effects of androgens on colon carcinogenesis were studied in 90 male Fisher-344 rats, given 10 weekly subcutaneous (SC) injections of 7.5 mg azoxymethane (AOM)/kg body weight, starting at 12 weeks of age. Thirty rats received the AOM course only (AOM only). Thirty rats were gonadectomized at 10 weeks of age and underwent the AOM course (castrated). In 30 additional castrated rats, hormone substitution was achieved by sc injection of 1 mg dehydrotestosterone (DHT) three times a week for 12 weeks. AOM was given concommitantly, starting at 12 weeks of age (castrated and hormone substituted). Animals were sacrificed 25 weeks after first AOM injection. As assessed by weekly body weight data and periodic serum determinations of carcinoembryonic antigen (CEA), castrated animals showed a delayed onset of colonic carcinogenesis, compared to AOM-only-treated and hormone-substituted animals. Castration resulted in a decrease of mean tumor size as well as overall incidence of colonic tumors, compared to that observed AOM-only and castrated and hormone-substituted group, respectively (27 vs 47 vs 53%). Castration also resulted in lower mean serum CEA levels at the end of experiment than in the AOM-only and castrated and hormone-substituted group. These findings suggest a promoting effect of androgens in colon carcinogenesis.

Androgens↗
PubMed1983

Increased serum concentration of free L-triiodothyronine in patients treated with L-thyroxine.

This study demonstrates that in spite of measured normal concentrations of carrier proteins one cannot deduce in all cases a normal fT3 from a normal level of TT3 when l-thyroxine given for diagnostic or therapeutic purposes is present in excess. The displacement of l-triiodothyronine from its binding sites is shown in 35 patients with non-toxic goitre who received an oral dose of 200 micrograms l-thyroxine/die for two weeks. Apart from a significant increase of TT4 (from 7.85 to 14.21 micrograms/dl equal + 81%) and of fT4 (from 1.58 to 3.7 ng/dl equal + 134%) there is only a slight increase in TT3 from 148 to 158 ng/dl (equal + 10%) after 14 days of treatment. By contrast fT3 rises clearly from 4.97 to 8.07 pg/ml equal + 63% (normal range: 2.8-5.6 pg/ml). Compared with the increase of TT3 (+ 10%) the free T3 rises by a factor of 6.3 (63%/10%). On account of higher affinity of l-thyroxine to binding proteins the free T4 is influenced to a lesser degree. Compared with the increase of TT4 (+ 81%) free T4 rises by a factor of 1.6 (134%/81%). It is supposed that the serum concentration of free T3 can be increased despite a normal concentration of TT3 when l-thyroxine is present in excess. Therefore, for laboratory work fT3 should be assigned a higher validity than TT3 when patients are treated with comparatively high doses of l-thyroxine.

Adult↗
PubMed1982

Hospital treatment of alcoholism: a profile of middle income Americans.

3,411 first admissions for alcoholism treatment to nine proprietary hospitals were studied with standardized questionnaire and diagnostic instruments. Despite the patients' relative economic and social stability, severe patterns of addictive alcohol use had developed and persisted for many years with a high incidence of alcohol-related and intercurrent medical disorders which required prompt medical intervention. Although most patients had a personal physician, less than 9% of referrals for hospital treatment for alcoholism were made by physicians; most patients responded to television outreach programs, recommendations by former patients or were self or family referred. This survey shows that persons who are neither socially disadvantaged nor economically deprived may have severe alcohol-related problems. Such patients constitute a significant challenge to the medical profession to develop strategies for early intervention and more efficacious treatment.

Adolescent↗
PubMed1982

Late results following different methods of cleft lip repair.

This is a review of the cleft lip repair of 232 patients. Three groups were compared, one repaired according to the Hagedorn-Le Mesurier-Steffensen technique, another by the Tennison method and a third using the Pfeifer wave-line procedure. Muscular union was best following Pfeifer's wave-line procedure. Both the Hagedorn-Le Mesurier-Steffensen and the Tennison lips were often too long, while the Pfeifer lips were more often too short. Reconstruction of Cupid's bow was somewhat more harmonious following Tennison's method. There was a trend towards fewer disturbing scars with the Pfeifer's procedure. We feel that these findings support our 1970 decision to operate all cleft lips according to the wave-line procedure.

Child↗
PubMed1982

Tumor volume correlated serum CEA levels in nude mice after primary xenotransplantation of human colorectal carcinoma.

Six different human colorectal adenocarcinomas were xenotransplanted onto six groups of female, syngeneic BALB/c nude mice, 4 weeks of age, under standardized pathogen-free conditions, and the serum CEA levels were determined by RIA. Five tumors grew positively, yielding a tumor take of nearly 90%. One tumor showed no growth macro-or microscopically. All animals were sacrificed after 12 weeks post-transplantation. Ten untreated controls showed a mean serum CEA concentration of 0.62 +/- 0.14 ng/ml. All tumor-bearing animals, including the negative tumor take group, exhibited increased CEA levels (1.0-60.0 ng/ml), which were positively correlated to tumor volume, measured in all tumor-bearing animal groups. However, no correlation was observed between patients' serum CEA levels, measured preoperatively, and CEA concentrations in nude mice. These findings suggest that further immunohistologic studies are necessary to evaluate the difference of CEA synthesis by microscopically identical original human and transplanted tumor tissue.

Adenocarcinoma↗